Individual variability in human blood metabolites identifies age-related differences
Open accessAbstract
Significance: Human blood provides a rich source of information about metabolites that reflects individual differences in health, disease, diet, and lifestyle. The coefficient of variation for human blood metabolites enriched in red blood cells or plasma was quantified after careful preparation. We identified 14 age-related metabolites. Metabolites that decline strikingly in the elderly include antioxidants and compounds involved in high physical activity, including carnosine, UDP-acetyl-glucosamine, ophthalmic acid,1,5-anhydroglucitol, NAD + , and leucine. Metabolites that increase significantly in the elderly include compounds related to declining renal and liver function. Statistical analysis suggests that certain age-related compounds that either increased or decreased in the elderly are correlated. Individual variability in blood metabolites may lead to identify candidates for markers of human aging or relevant diseases.
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- Authors
- Chaleckis, R., Murakami, I., Takada, J., Kondoh, H., & Yanagida, M.
- Affiliations
- Okinawa Institute of Science and Technology Graduate University (JP)
- Kyoto University (JP)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-03-28
- Volume
- 113
- Issue
- 16
- Pages
- 4252-4259
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4843419
- OpenAlex
- W2318079341
- Cited by
- 373
- References
- 3
- Citations by year
- 2026: 20 · 2025: 26 · 2024: 46 · 2023: 38 · 2022: 52 · 2021: 50 · 2020: 49 · 2019: 36 · 2018: 25 · 2017: 25 · 2016: 6
- FWCI
- 15.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Okinawa Institute of Science and Technology Graduate University (-)
- Japan Science and Technology Agency (-)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolomics and Mass Spectrometry Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Metabolism and Genetic Disorders
- Keywords
- blood metabolites, aging, interindividual variability, coefficient of variation, age-related changes, antioxidant production, urea metabolism, NAD+, NADPH, carnosine, 1,5-anhydroglucitol, pantothenic acid, citrulline, leucine, isoleucine, ophthalmic acid
- MeSH terms
- Adenosine Triphosphate, Adult, Aged, Aged, 80 and over, Aging, Antioxidants, Female, Glutathione, Humans, Male
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