The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength
Open accessAbstract
Significance: Short-term plasticity (STP) of synaptic connections underlies many basic signal processing capabilities of the brain, such as gain control, temporal filtering, and adaptation. Glutamatergic synapses, the predominant excitatory synapses in the brain, display large variability both in basal synaptic strength and in STP. We show that a small fraction of release-ready vesicles are released with much higher probability than other vesicles. The number of these “superprimed” vesicles is variable among synapses, but increases strongly after application of phorbol ester, an analogue of the second messenger diacylglycerol, and after inducing posttetanic potentiation. Thus, modulatory transmitter systems, acting through the phospholipase-C–diacylglycerol pathway, will be able to upregulate superprimed vesicles and thereby boost synaptic strength at the onset of burst-like activity.
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“These might be “superprimed” vesicles [84,85].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [85]
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1 retracted
RETRACTED: Protein kinase C is a calcium sensor for presynaptic short-term plasticity
Fioravante, D., Chu, Y., de Jong, A. P. H., Leitges, M., Kaeser, P. S., & Regehr, W. G. (2014) · eLife · doi:10.7554/elife.03011 · Cited by 16
RetractedShort-Term Synaptic Plasticity
Zucker, R. S., & Regehr, W. G. (2002) · Annual Review of Physiology · doi:10.1146/annurev.physiol.64.092501.114547 · Cited by 5,068
Synaptic depression and cortical gain control
Abbott, L. F., Varela, J. A., Sen, K., & Nelson, S. B. (1997) · Science · doi:10.1126/science.275.5297.221 · Cited by 1,690
Synaptic theory of working memory
Mongillo, G., Barak, O., & Tsodyks, M. (2008) · Science · doi:10.1126/science.1150769 · Cited by 1,253
Heterogeneity of release probability, facilitation, and depletion at central synapses
Dobrunz, L. E., & Stevens, C. F. (1997) · Neuron · doi:10.1016/s0896-6273(00)80338-4 · Cited by 1,183
Südhof, T. C. (2012) · Neuron · doi:10.1016/j.neuron.2012.06.012 · Cited by 1,062
An optimized fluorescent probe for visualizing glutamate neurotransmission
Marvin, J., Borghuis, B., Tian, L., Cichon, J., Harnett, M. T., Akerboom, J., Gordus, A., Renninger, S., Chen, T.-W., Bargmann, C., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2333 · Cited by 965
Neuromodulation of Brain States
Lee, S., & Dan, Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.012 · Cited by 697
Schneggenburger, R., Meyer, A. C., & Neher, E. (1999) · Neuron · doi:10.1016/s0896-6273(00)80789-8 · Cited by 627
Self-citationThe probability of transmitter release at a mammalian central synapse
Hessler, N. A., Shirke, A. M., & Malinow, R. (1993) · Nature · doi:10.1038/366569a0 · Cited by 617
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Dynamically Primed Synaptic Vesicle States: Key to Understand Synaptic Short-Term Plasticity
Neher, E., & Brose, N. (2018) · Neuron · doi:10.1016/j.neuron.2018.11.024 · Cited by 210
Self-citationUltrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses
Helassa, N., Dürst, C. D., Coates, C., Kerruth, S., Arif, U., Schulze, C., Wiegert, J. S., Geeves, M. A., Oertner, T. G., & Török, K. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1720648115 · Cited by 149
The control of release probability at nerve terminals
Dittman, J. S., & Ryan, T. A. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0111-3 · Cited by 127
Vandael, D., Borges-Merjane, C., Zhang, X., & Jonas, P. (2020) · Neuron · doi:10.1016/j.neuron.2020.05.013 · Cited by 114
Munc13-1 and Munc18-1 together prevent NSF-dependent de-priming of synaptic vesicles
He, E., Wierda, K. D. B., van Westen, R., Broeke, J. H. P., Toonen, R. F. G., Cornelisse, L. N., & Verhage, M. (2017) · Nature Communications · doi:10.1038/ncomms15915 · Cited by 98
Metadata
- Authors
- Taschenberger, H., Woehler, A., & Neher, E.
- Affiliations
- Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 (DE)
- Corresponding author
- Neher, Erwin
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-07-18
- Volume
- 113
- Issue
- 31
- Pages
- E4548-57
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4978258
- OpenAlex
- W2477973977
- Cited by
- 128
- References
- 67
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 13 · 2023: 18 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 15 · 2018: 13 · 2017: 16 · 2016: 1
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (CNMPB)
- European Commission Directorate-General for Research and Innovation (FP7-HEALTH-F2-2009-241498)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic vesicles, short-term plasticity, post-tetanic potentiation, short-term depression, synaptic facilitation, phospholipase C, diacylglycerol, phorbol ester, glutamatergic synapses
- MeSH terms
- Algorithms, Animals, Animals, Newborn, Cells, Cultured, Electric Stimulation, Female, Male, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Synapses, Synaptic Vesicles, Signal Transduction, Rats, Wistar, Glutamic Acid, Excitatory Postsynaptic Potentials
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