Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses
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A stunning example of synaptic diversity is the postsynaptic target cell-type-dependent difference in synaptic efficacy in cortical networks. Here, we show that CA1 pyramidal cell (PC) to fast spiking interneuron (FSIN) connections have 10-fold larger release probability (P v ) than those on oriens lacunosum-moleculare (O-LM) interneurons. Freeze-fracture immunolabeling revealed that different nano-topologies and coupling distances between Ca 2+ channels and release sites (RSs) are not responsible for the distinct P v . Although [Ca 2+ ] transients are 40% larger in FSINs innervating boutons, when [Ca 2+ ] entry is matched in the two bouton populations, EPSCs in O-LM cells are still 7-fold smaller. However, application of a phorbol ester analog resulted in a ∼2.5-fold larger augmentation at PC – O-LM compared to PC – FSIN synapses, suggesting incomplete docking or priming of vesicles. Similar densities of docked vesicles rule out distinct RS occupancies and demonstrate that incompletely primed, but docked, vesicles limit the output of PC – O-LM synapses.
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The corresponding active zone membrane association can be detected by freeze-fracture replica labeling.
“The corresponding AZ membrane association can be detected by FRL [23,61,66,67].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [23]
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Martín‐Belmonte, A., Aguado, C., Alfaro‐Ruiz, R., Kulik, Á., de la Ossa, L., Moreno‐Martínez, A. E., Alberquilla, S., García‐Carracedo, L., Fernández, M., Fajardo‐Serrano, A., et al. (2024) · Brain Pathology · doi:10.1111/bpa.13279 · Cited by 10 · see citing works
Blaum, N., Ghelani, T., Götz, T., Chronister, K. S., Bengochea, M., Ceresnova, L., Christensen, C., Moulin, T. C., Kern, H. B., Thomas, U., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2514151122 · Cited by 9 · see citing works
Input/Output Relationships for the Primary Hippocampal Circuit
Gunn, B. G., Pruess, B. S., Gall, C. M., & LYNCH, G. S. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0130-24.2024 · Cited by 8 · see citing works
Rapid presynaptic maturation in naturally regenerating axons of the adult mouse olfactory nerve
Browne, L., Crespo, A., & Grubb, M. S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111750 · Cited by 8 · see citing works
Loss of postsynaptic NMDARs drives nanoscale reorganization of Munc13-1 and PSD-95Preprint
Dharmasri, P. A., DeMarco, E. M., Anderson, M. C., Levy, A. D., & Blanpied, T. A. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.12.574705 · Cited by 8 · see citing works
Medeiros, A. T., Gratz, S. J., Delgado, A., Ritt, J. T., & O’Connor-Giles, K. M. (2023) · eLife · doi:10.7554/elife.88412 · Cited by 23 · see citing works
Midorikawa, M., Sakamoto, H., Nakamura, Y., Hirose, K., & Miyata, M. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114770 · Cited by 7 · see citing works
A dendritic substrate for temporal diversity of cortical inhibitionPreprint
Morabito, A., Zerlaut, Y., Dhanasobhon, D., Berthaux, E., Tzilivaki, A., Moneron, G., Cathala, L., Poirazi, P., Bacci, A., DiGregorio, D. A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.09.602783 · Cited by 7 · see citing works
Pre- versus Post-synaptic Forms of LTP in Two Branches of the Same Hippocampal Afferent
Quintanilla, J., Jia, Y., Pruess, B. S., Chavez, J., Gall, C. M., LYNCH, G. S., & Gunn, B. G. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1449-23.2024 · Cited by 7 · see citing works
Dynamic nanoscale architecture of synaptic vesicle fusion in mouse hippocampal neurons
Kroll, J., Kravčenko, U., Sadeghi, M., Diebolder, C. A., Ivanov, L., Lubas, M., Sprink, T., Schacherl, M., Kudryashev, M., & Rosenmund, C. (2025) · Nature Communications · doi:10.1038/s41467-025-67291-6 · Cited by 5 · see citing works
An Exact Transient Solution Characterizing Stochastic Dynamics of Neuronal Synaptic TransmissionPreprint
Singh, A. (2023) · doi:10.31219/osf.io/fdq3c · Cited by 5 · see citing works
Medeiros, A. T., Gratz, S. J., Delgado, A., Ritt, J. T., & O’Connor-Giles, K. M. (2023) · eLife · doi:10.7554/elife.88412.1 · Cited by 5 · see citing works
Lőrincz, A., Ashaber, M., & Nusser, Z. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.0645-25.2025 · Cited by 4 · see citing works
Self-citationMedeiros, A. T., Gratz, S. J., Delgado, A., Ritt, J. T., & O’Connor-Giles, K. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.04.02.535290 · Cited by 4 · see citing works
Luján, R., Turégano-López, M., Aguado, C., & Merchán-Pérez, Á. (2024) · Advanced technology in neuroscience . · doi:10.4103/atn.atn-d-24-00009 · Cited by 3 · see citing works
Koppensteiner, P., Bhandari, P., Önal, C., Borges-Merjane, C., Monnier, E. L., Nakamura, Y., Sadakata, T., Sanbo, M., Hirabayashi, M., Brose, N., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.10.28.514202 · Cited by 3 · see citing works
Chanaday, N. L. (2026) · Advances in neurobiology · doi:10.1007/978-3-032-12594-1_3 · Cited by 2 · see citing works
Fekete, Z., Weisz, F., Karlócai, M. R., Veres, J. M., Andrási, T., & Hájos, N. (2024) · The Journal of Physiology · doi:10.1113/jp286284 · Cited by 2 · see citing works
Kim, H. S., Santana, G. M. T., Sancer, G., Emonet, T., & Jeanne, J. M. (2024) · Current Biology · doi:10.1016/j.cub.2025.05.051 · Cited by 3 · see citing works
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Medeiros, A. T., Gratz, S. J., Delgado, A., Ritt, J. T., & O’Connor-Giles, K. M. (2024) · eLife · doi:10.7554/elife.88412.2 · Cited by 2 · see citing works
Shin, J., Lee, S. Y., Kim, Y., & Lee, S. (2026) · eLife · doi:10.7554/elife.102923.6 · Cited by 1 · see citing works
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Shin, J., Lee, S. Y., Kim, Y., & Lee, S. (2025) · eLife · doi:10.7554/elife.102923 · Cited by 1 · see citing works
Synaptic and dendritic architecture of different types of hippocampal somatostatin interneuronsPreprint
Takács, V. T., Bardóczi, Z., Orosz, Á., Major, Á., Tar, L., Berki, P., Papp, P., Mayer, M. I., Sebők, H., Zsolt, L., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.14.540675
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Shin, J., Lee, S. Y., Kim, Y., & Lee, S. (2025) · eLife · doi:10.7554/elife.102923.2
Shin, J., Lee, S. Y., Kim, Y., & Lee, S. (2025) · eLife · doi:10.7554/elife.102923.3
Polyadic synapses introduce unique wiring architectures in T5 cells of DrosophilaPreprint
Samara, E., & Borst, A. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.04.668437
Shin, J., Lee, S. Y., Kim, Y., & Lee, S. (2025) · eLife · doi:10.7554/elife.102923.4
Polyadic synapses introduce unique wiring architectures in T5 cells of Drosophila
Samara, E., & Borst, A. (2025) · PLoS ONE · doi:10.1371/journal.pone.0334925
Shin, J., Lee, S. Y., Kim, Y., & Lee, S. (2026) · eLife · doi:10.7554/elife.102923.5
Selective, genetically induced increase in synaptic vesicle priming
Aldahabi, M., Bálint, F., Lőrincz, A., Lipstein, N., Brose, N., & Nusser, Z. (2026) · Science Advances · doi:10.1126/sciadv.aee6848
Self-citationUltrastructural and molecular analysis of cortico-striatal dopamine hub synapses
Lapios, P. (2024) · theses.fr (ABES) · doi:10.70675/527646a6zd9b5z4935z80ebz0950bba9d08e
The Primary Hippocampal Circuit: New Lessons about an Old Network
Gunn, B. G., & LYNCH, G. S. (2026) · The Neuroscientist · doi:10.1177/10738584261476032
- Authors
- Aldahabi, M., Balint, F., Holderith, N., Lorincz, A., Reva, M., & Nusser, Z.
- Affiliations
- Semmelweis University (HU)
- Centre National de la Recherche Scientifique (FR)
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2022-12
- Volume
- 110
- Issue
- 24
- Pages
- 4144-4161.e7
- ISSN
- 0896-6273 (ISSN-L)
- PMC
- PMC9796815
- OpenAlex
- W4306748254
- Cited by
- 50
- References
- 81
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 20 · 2023: 9 · 2022: 2
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Neuron (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Repository of the Academy's Library (Library of the Hungarian Academy of Sciences) (acceptedVersion)
- Infoscience (Ecole Polytechnique Fédérale de Lausanne) (submittedVersion, cc-by-nc-nd)
- Funders
- H2020 European Research Council (787157)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- synaptic vesicle priming, release probability, hippocampal CA1, pyramidal neurons, fast-spiking interneurons, oriens-lacunosum moleculare interneurons, synaptic diversity, calcium transients, vesicle docking, phorbol ester, synaptic transmission
- MeSH terms
- Hippocampus, Interneurons, Probability, Synapses, Synaptic Vesicles
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