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Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength
Open accessAbstract
Significance: Short-term plasticity (STP) of synaptic connections underlies many basic signal processing capabilities of the brain, such as gain control, temporal filtering, and adaptation. Glutamatergic synapses, the predominant excitatory synapses in the brain, display large variability both in basal synaptic strength and in STP. We show that a small fraction of release-ready vesicles are released with much higher probability than other vesicles. The number of these “superprimed” vesicles is variable among synapses, but increases strongly after application of phorbol ester, an analogue of the second messenger diacylglycerol, and after inducing posttetanic potentiation. Thus, modulatory transmitter systems, acting through the phospholipase-C–diacylglycerol pathway, will be able to upregulate superprimed vesicles and thereby boost synaptic strength at the onset of burst-like activity.
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“These might be “superprimed” vesicles [84,85].”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [85]
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Metadata
- Authors
- Taschenberger, H., Woehler, A., & Neher, E.
- Affiliations
- Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 (DE)
- Corresponding author
- Neher, Erwin
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-07-18
- Volume
- 113
- Issue
- 31
- Pages
- E4548-57
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4978258
- OpenAlex
- W2477973977
- Cited by
- 128
- References
- 67
- Citations by year
- 2026: 10 · 2025: 12 · 2024: 13 · 2023: 18 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 15 · 2018: 13 · 2017: 16 · 2016: 1
- FWCI
- 8.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- Deutsche Forschungsgemeinschaft (CNMPB)
- European Commission Directorate-General for Research and Innovation (FP7-HEALTH-F2-2009-241498)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic vesicles, short-term plasticity, post-tetanic potentiation, short-term depression, synaptic facilitation, phospholipase C, diacylglycerol, phorbol ester, glutamatergic synapses
- MeSH terms
- Algorithms, Animals, Animals, Newborn, Cells, Cultured, Electric Stimulation, Female, Male, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Synapses, Synaptic Vesicles, Signal Transduction, Rats, Wistar, Glutamic Acid, Excitatory Postsynaptic Potentials
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