Cited by 128Neuroscience and Neuropharmacology ResearchCellular transport and secretionNeural dynamics and brain function

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Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength

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Taschenberger, Holger, Woehler, Andrew, Neher, Erwin·2016·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.1606383113PMC PMC4978258

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Abstract

Significance: Short-term plasticity (STP) of synaptic connections underlies many basic signal processing capabilities of the brain, such as gain control, temporal filtering, and adaptation. Glutamatergic synapses, the predominant excitatory synapses in the brain, display large variability both in basal synaptic strength and in STP. We show that a small fraction of release-ready vesicles are released with much higher probability than other vesicles. The number of these “superprimed” vesicles is variable among synapses, but increases strongly after application of phorbol ester, an analogue of the second messenger diacylglycerol, and after inducing posttetanic potentiation. Thus, modulatory transmitter systems, acting through the phospholipase-C–diacylglycerol pathway, will be able to upregulate superprimed vesicles and thereby boost synaptic strength at the onset of burst-like activity.

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Authors: Taschenberger, H., Woehler, A., & Neher, E.
Affiliations: Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 (DE)
Corresponding author: Neher, Erwin
ORCID: Taschenberger, Holger
Woehler, Andrew
Neher, Erwin
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2016-07-18
Volume: 113
Issue: 31
Pages: E4548-57
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.1606383113
PMC: PMC4978258
OpenAlex: W2477973977
Cited by: 128
References: 67
Citations by year: 2026: 10 · 2025: 12 · 2024: 13 · 2023: 18 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 15 · 2018: 13 · 2017: 16 · 2016: 1
FWCI: 8.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.pnas.org/preview_site/misc/userlicense.xhtml (vor)
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders: Deutsche Forschungsgemeinschaft (CNMPB)
European Commission Directorate-General for Research and Innovation (FP7-HEALTH-F2-2009-241498)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: synaptic vesicles, short-term plasticity, post-tetanic potentiation, short-term depression, synaptic facilitation, phospholipase C, diacylglycerol, phorbol ester, glutamatergic synapses
MeSH terms: Algorithms, Animals, Animals, Newborn, Cells, Cultured, Electric Stimulation, Female, Male, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Synapses, Synaptic Vesicles, Signal Transduction, Rats, Wistar, Glutamic Acid, Excitatory Postsynaptic Potentials

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Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength

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