The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals
Open accessAbstract
Significance: Cost-efficient production of fuels and oleochemicals requires the host strain to be highly lipogenic and suitable for large-scale production. We demonstrate that Yarrowia lipolytica represents a promising biorefinery platform for sustainable production of drop-in transportation fuels and oleochemicals. Understanding the mechanistic details of the lipogenic phenotype, particularly the cellular compartmentalization of distinct metabolic pathways, fatty acid synthase structure, activating free fatty acids to acyl-CoAs, and decoupling nitrogen starvation from lipogenesis, allowed us to efficiently produce fatty acid ethyl esters, fatty alkanes, medium chain-length fatty acids, fatty alcohols, and triacylglycerides (TAGs). We envision that this report constitutes foundational work in developing an oleaginous yeast platform to upgrade low-value carbons to high-value fuels and oleochemicals in the foreseeable future.
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Li-Beisson, Y., Shorrosh, B., Beisson, F., Andersson, M. X., Arondel, V., Bates, P. D., Baud, S., Bird, D., DeBono, A., Durrett, T. P., et al. (2013) · The Arabidopsis Book · doi:10.1199/tab.0161 · Cited by 1,513
Microbial Biosynthesis of Alkanes
Schirmer, A., Rude, M. A., Li, X., Popova, E., & del Cardayre, S. B. (2010) · Science · doi:10.1126/science.1187936 · Cited by 1,040
Biodiesel and renewable diesel: A comparison
Knothe, G. (2010) · Progress in Energy and Combustion Science · doi:10.1016/j.pecs.2009.11.004 · Cited by 983
Tai, M., & Stephanopoulos, G. (2013) · Metabolic Engineering · doi:10.1016/j.ymben.2012.08.007 · Cited by 678
Self-citationMicrodiesel: Escherichia coli engineered for fuel production
Kalscheuer, R., Stölting, T., & Steinbüchel, A. (2006) · Microbiology · doi:10.1099/mic.0.29028-0 · Cited by 490
Improving fatty acids production by engineering dynamic pathway regulation and metabolic control
Xu, P., Li, L., Zhang, F., Stephanopoulos, G., & Koffas, M. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1406401111 · Cited by 487
Self-citationModular optimization of multi-gene pathways for fatty acids production in E. coli
Xu, P., Gu, Q., Wang, W., Wong, L., Bower, A. G. W., Collins, C. H., & Koffas, M. A. G. (2013) · Nature Communications · doi:10.1038/ncomms2425 · Cited by 460
Self-citationRunguphan, W., & Keasling, J. D. (2014) · Metabolic Engineering · doi:10.1016/j.ymben.2013.07.003 · Cited by 411
Microbial Type I Fatty Acid Synthases (FAS): Major Players in a Network of Cellular FAS Systems
Schweizer, E., & Hofmann, J. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.3.501-517.2004 · Cited by 384
Li-Beisson, Y., Shorrosh, B., Beisson, F., Andersson, M. X., Arondel, V., Bates, P. D., Baud, S., Bird, D., DeBono, A., Durrett, T. P., et al. (2010) · The Arabidopsis Book · doi:10.1199/tab.0133 · Cited by 367
Cited by
Revisiting metabolic engineering strategies for microbial synthesis of oleochemicals
Yan, Q., & Pfleger, B. F. (2020) · Metabolic Engineering · doi:10.1016/j.ymben.2019.04.009 · Cited by 105
Recent advances in biofuel production through metabolic engineering
Joshi, S., & Mishra, S. (2022) · Bioresource Technology · doi:10.1016/j.biortech.2022.127037 · Cited by 87
Integrated diesel production from lignocellulosic sugars via oleaginous yeast
Sànchez i Nogué, V., Black, B. A., Kruger, J. S., Singer, C. A., Ramirez, K. J., Reed, M. L., Cleveland, N. S., Singer, E. R., Yi, X., Yeap, R. Y., et al. (2018) · Green Chemistry · doi:10.1039/c8gc01905c · Cited by 76
Metadata
- Authors
- Xu, P., Qiao, K., Ahn, W. S., & Stephanopoulos, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2016-09-12
- Volume
- 113
- Issue
- 39
- Pages
- 10848-10853
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2519917040
- Cited by
- 441
- References
- 38
- FWCI
- 21.37
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xu, P., Qiao, K., Ahn, W. S., & Stephanopoulos, G. (2016). Engineering Yarrowia lipolytica as a platform for synthesis of drop-in transportation fuels and oleochemicals. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1607295113
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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