Recent advances in biofuel production through metabolic engineering
Abstract
Rising global energy demands and climate crisis has created an unprecedented need for the bio-based circular economy to ensure sustainable development with the minimized carbon footprint. Along with conventional biofuels such as ethanol, microbes can be used to produce advanced biofuels which are equivalent to traditional fuels in their energy efficiencies and are compatible with already established infrastructure and hence can be directly blended in higher proportions without overhauling of the pre-existing setup. Metabolic engineering is at the frontiers to develop microbial chassis for biofuel bio-foundries to meet the industrial needs for clean energy. This review does a thorough inquiry of recent developments in metabolic engineering for increasing titers, rates, and yields (TRY) of biofuel production by engineered microorganisms.
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Optimizing key enzymatic steps and redirecting metabolic fluxes has achieved significant improvements in biomass composition and biofuel precursor synthesis.
“By optimizing key enzymatic steps and redirecting metabolic fluxes, researchers have achieved significant improvements in biomass composition and biofuel precursor synthesis [109].”
From Algal-Based Carbonaceous Materials for Environmental Remediation: Advances in Wastewater Treatment, Carbon Sequestration, and Biofuel Applications (2025) · cites this paper as [109]
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Critical review of biochemical pathways to transformation of waste and biomass into bioenergy
Manikandan, S., Vickram, S., Sirohi, R., Subbaiya, R., Krishnan, R. Y., Karmegam, N., Sumathijones, C., Rajagopal, R., Chang, S. W., Ravindran, B., et al. (2023) · Bioresource Technology · doi:10.1016/j.biortech.2023.128679 · Cited by 268 · see citing works
Padder, S. A., Khan, R., & Rather, R. A. (2024) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2024.107220 · Cited by 97 · see citing works
Recent advances in wastewater microalgae-based biofuels production: A state-of-the-art review
Ali, S. S., Mastropetros, S. G., Schagerl, M., Sakarika, M., Elsamahy, T., El-Sheekh, M., Sun, J., & Kornaros, M. (2022) · Energy Reports · doi:10.1016/j.egyr.2022.09.143 · Cited by 86 · see citing works
González Fernández, L. A., Medellín Castillo, N. A., Sánchez Polo, M., Navarro Frómeta, A. E., & Vilasó Cadre, J. E. (2025) · Processes · doi:10.3390/pr13020556 · Cited by 37 · see citing works
Production Efficiency of Advanced Liquid Biofuels: Prospects and Challenges
Mizik, T., Igbeghe, C. B., & Deák, Z. (2025) · Energies · doi:10.3390/en18041008 · Cited by 7 · see citing works
- Authors
- Joshi, S., & Mishra, S.
- Affiliations
- National Institute of Occupational Health (IN)
- Corresponding author
- Joshi, Swati
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2022-05
- Volume
- 352
- Pages
- 127037
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W4221074570
- Cited by
- 87
- References
- 100
- Citations by year
- 2026: 14 · 2025: 23 · 2024: 19 · 2023: 18 · 2022: 13
- FWCI
- 1.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Physical Sciences › Engineering › Biomedical Engineering › Biofuel production and bioconversion
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Biochemical and biochemical processes
- Keywords
- biofuel production, metabolic engineering, advanced biofuels, microbial chassis, engineered microorganisms, ethanol, sustainable energy
- MeSH terms
- Ethanol, Biofuels, Metabolic Engineering
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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