Cited by 376Cellular Mechanics and Interactions3D Printing in Biomedical ResearchCancer Cells and Metastasis

Oriented collagen fibers direct tumor cell intravasation

Open access
Han, Weijing, Chen, Shaohua, Yuan, Wei, Fan, Qihui, Tian, Jianxiang, Wang, Xiaochen, Chen, Longqing, Zhang, Xixiang +6 more·2016·Proceedings of the National Academy of Sciences

Abstract

In this work, we constructed a Collagen I-Matrigel composite extracellular matrix (ECM). The composite ECM was used to determine the influence of the local collagen fiber orientation on the collective intravasation ability of tumor cells. We found that the local fiber alignment enhanced cell-ECM interactions. Specifically, metastatic MDA-MB-231 breast cancer cells followed the local fiber alignment direction during the intravasation into rigid Matrigel (∼10 mg/mL protein concentration).

Integrity signals

Registry

Crossref · 10.1073/pnas.1610347113

Cites

48 of 48 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • ECM orientation can be achieved by providing directional forces during or after fibril polymerization, such as external strain, flow, or shear.

    “ECM orientation can be further achieved by providing directional forces during or after fibril polymerization, such as by external strain, flow, or shear [21,37,38].”

Cites

1 retracted

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Han, W., Chen, S., Yuan, W., Fan, Q., Tian, J., Wang, X., Chen, L., Zhang, X., Wei, W., Liu, R., Qu, J., Jiao, Y., Austin, R. H., & Liu, L.
Affiliations
  • Chinese Academy of Sciences (CN)
  • Arizona State University (US)
  • Shenzhen University (CN)
  • King Abdullah University of Science and Technology (SA)
  • Chongqing University (CN)
Venue
Proceedings of the National Academy of Sciences
Published
2016-09-23
Volume
113
Issue
40
Pages
11208-11213
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2464386848
Cited by
376
References
48
Citations by year
2026: 15 · 2025: 42 · 2024: 46 · 2023: 44 · 2022: 51 · 2021: 51 · 2020: 50 · 2019: 41 · 2018: 21 · 2017: 12 · 2016: 1
FWCI
17.13
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • King Abdullah University of Science and Technology Repository (King Abdullah University of Science and Technology) (submittedVersion)
Funders
  • State Key Development Program Basic Research China (2013CB837200)
  • National Science Foundation China (11474345, 11274200)
  • Beijing Natural Science Foundation (7154221)
  • HHS | NIH | National Cancer Institute (U54CA143803)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
  • Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
  • Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Keywords
collagen fiber orientation, tumor cell intravasation, extracellular matrix, cell-matrix interactions, collective cell migration, breast cancer metastasis, MDA-MB-231 cells, Matrigel
MeSH terms
Biopsy, Collagen, Extracellular Matrix, Female, Humans, Neoplasm Metastasis, Neoplasms, Disease Progression, Cell Line, Tumor, Cell Proliferation, Time-Lapse Imaging

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review