The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing
Open accessAbstract
Significance: Alternative RNA splicing and the spliceosome machinery have been implicated in cancer progression. A genome-wide CRISPR screen identified the RNA processing factor heterogeneous nuclear ribonucleoprotein L (HNRNPL) as required for prostate cancer growth by regulating alternative RNA splicing and circular RNA formation. HNRNPL and its RNA clients are overexpressed during prostate cancer progression, supporting their potential role as therapeutic targets.
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Citations
Cites
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Genome-scale CRISPR-Cas9 knockout screening in human cells
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“Moreover, recent studies suggested that superenhancer-associated genes tend to be functionally important in the control of cell identity and disease (27).”
BackgroundIntegrative Clinical Genomics of Advanced Prostate Cancer
Robinson, D., Van Allen, E. M., Wu, Y.-M., Schultz, N., Lonigro, R. J., Mosquera, J.-M., Montgomery, B., Taplin, M.-E., Pritchard, C. C., Attard, G., et al. (2015) · Cell · doi:10.1016/j.cell.2015.05.001 · Cited by 3,645
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Complementary Sequence-Mediated Exon Circularization
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“Minigene assays of HNRNPL confirmed the previous model that trans factor binding or direct complementary sequence pairing at two flanking introns could promote circRNA formation by bringing back spliced exon ends into close proximity (32, 36, 37).”
Background
Cited by
The emerging roles of circRNAs in cancer and oncology
Kristensen, L. S., Jakobsen, T., Hager, H., & Kjems, J. (2022) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00585-y · Cited by 1,256
Zang, J., Lu, D., & Xu, A. (2020) · Journal of Neuroscience Research · doi:10.1002/jnr.24356 · Cited by 641
Circular RNA: An emerging non-coding RNA as a regulator and biomarker in cancer
Chen, B., & Huang, S. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.011 · Cited by 308
Stelloo, S., Nevedomskaya, E., Kim, Y., Hoekman, L., Bleijerveld, O. B., Mirza, T., Wessels, L. F. A., van Weerden, W. M., Altelaar, A. F. M., Bergman, A. M., et al. (2018) · Oncogene · doi:10.1038/onc.2017.330 · Cited by 118
Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry
Yazaki, J., Yamanashi, T., Nemoto, S., Kobayashi, A., Han, Y.-W., Hasegawa, T., Iwase, A., Ishikawa, M., Konno, R., Imami, K., et al. (2024) · Biology Methods and Protocols · doi:10.1093/biomethods/bpae039 · Cited by 2
Metadata
- Authors
- Fei, T., Chen, Y., Xiao, T., Li, W., Cato, L., Zhang, P., Cotter, M. B., Bowden, M., Lis, R. T., Zhao, S. G., Wu, Q., Feng, F. Y., Loda, M., He, H. H., Liu, X. S., & Brown, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-06-13
- Volume
- 114
- Issue
- 26
- Pages
- E5207-E5215
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2625817416
- Cited by
- 338
- References
- 14
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fei, T., Chen, Y., Xiao, T., Li, W., Cato, L., Zhang, P., Cotter, M. B., Bowden, M., Lis, R. T., Zhao, S. G., Wu, Q., Feng, F. Y., Loda, M., He, H. H., Liu, X. S., & Brown, M. (2017). Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1617467114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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