The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.
Systematic dissection of genomic features determining transcription factor binding and enhancer function
Open accessAbstract
Significance: A central question in biology is how transcription factors (TFs) recognize specific binding sites in enhancers and regulate gene expression. In general, only a fraction of potential binding sites for TFs are occupied in a particular cell type. TF affinity for a motif site, local interactions among TFs, and larger-scale chromatin accessibility can influence binding, although the relative contributions of these factors is unclear. Moreover, little is known about how specific combinations of TFs control quantitative gene expression once bound. Here, we use large-scale synthetic biology approaches to explore the features that govern TF binding vs. enhancer activity. This approach provides a paradigm for systematic study of key regulatory sequences within enhancers and how they interact to influence gene expression.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“A major advantage of MPRAs is that sequences to be tested can simply be synthesized, enabling straightforward saturation mutagenesis [G] of enhancers67,184,185 as well as programming synthetic enhancers to inform modelling of their properties186,187.”
From Towards a comprehensive catalogue of validated and target-linked human enhancers (2020) · cites this paper as [186]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
An integrated encyclopedia of DNA elements in the human genome
The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072
Self-citationHeinz, S., Benner, C., Spann, N., Bertolino, E., Lin, Y. C., Laslo, P., Cheng, J. X., Murre, C., Singh, H., & Glass, C. K. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.004 · Cited by 13,382
Integrative analysis of 111 reference human epigenomes
Roadmap Epigenomics Consortium, Kundaje, A., Meuleman, W., Ernst, J., Bilenky, M., Yen, A., Heravi-Moussavi, A., Kheradpour, P., Zhang, Z., Wang, J., et al. (2015) · Nature · doi:10.1038/nature14248 · Cited by 6,368
Self-citationFIMO: scanning for occurrences of a given motif
Grant, C. E., Bailey, T. L., & Noble, W. S. (2011) · Bioinformatics · doi:10.1093/bioinformatics/btr064 · Cited by 4,247
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Mikkelsen, T. S., Ku, M., Jaffe, D. B., Issac, B., Lieberman, E., Giannoukos, G., Alvarez, P., Brockman, W., Kim, T.-K., Koche, R. P., et al. (2007) · Nature · doi:10.1038/nature06008 · Cited by 4,129
Self-citationGenome-Wide Mapping of in Vivo Protein-DNA Interactions
Johnson, D. S., Mortazavi, A., Myers, R. M., & Wold, B. (2007) · Science · doi:10.1126/science.1141319 · Cited by 2,927
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679
Transcription factors: from enhancer binding to developmental control
Spitz, F., & Furlong, E. E. M. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3207 · Cited by 2,227
Kamei, Y., Xu, L., Heinzel, T., Torchia, J., Kurokawa, R., Gloss, B., Lin, S.-C., Heyman, R. A., Rose, D. W., Glass, C. K., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81118-6 · Cited by 2,150
TRANSFAC(R) and its module TRANSCompel(R): transcriptional gene regulation in eukaryotes
Matys, V. (2005) · Nucleic Acids Research · doi:10.1093/nar/gkj143 · Cited by 2,142
Genome-Wide Location and Function of DNA Binding Proteins
Ren, B., Robert, F., Wyrick, J. J., Aparicio, O. M., Jennings, E. G., Simon, I., Zeitlinger, J., Schreiber, J., Hannett, N. M., Kanin, E. I., et al. (2000) · Science · doi:10.1126/science.290.5500.2306 · Cited by 1,768
C/EBPα induces adipogenesis through PPARγ: a unified pathwayPreprint
Rosen, E. D., Hsu, C.-H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., & Spiegelman, B. M. (2002) · Genes & Development · doi:10.1101/gad.948702 · Cited by 1,497
Robertson, G., Hirst, M., Bainbridge, M., Bilenky, M., Zhao, Y., Zeng, T., Euskirchen, G., Bernier, B., Varhol, R., Delaney, A., et al. (2007) · Nature Methods · doi:10.1038/nmeth1068 · Cited by 1,454
Architecture of the human regulatory network derived from ENCODE data
Gerstein, M., Kundaje, A. B., Hariharan, M., Landt, S. G., Yan, K., Cheng, C., Mu, X. J., Khurana, E., Rozowsky, J. S., Alexander, R. P., et al. (2012) · Nature · doi:10.1038/nature11245 · Cited by 1,451
DNA-Binding Specificities of Human Transcription Factors
Jolma, A., Yan, J., Whitington, T., Toivonen, J., Nitta, K. R., Rastas, P. M. A., Morgunova, E. Y., Enge, M., Taipale, M., Wei, G., et al. (2013) · Cell · doi:10.1016/j.cell.2012.12.009 · Cited by 1,262
Transcriptional activation by recruitment
Ptashne, M., & Gann, A. (1997) · Nature · doi:10.1038/386569a0 · Cited by 1,158
A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
Wei, C.-L., Wu, Q., Vega, V. B., Chiu, K. P., Ng, P., Zhang, T., Shahab, A., Yong, H. C., Fu, Y., Weng, Z., et al. (2006) · Cell · doi:10.1016/j.cell.2005.10.043 · Cited by 1,141
Discovery and characterization of chromatin states for systematic annotation of the human genome
Ernst, J., & Kellis, M. (2010) · Nature Biotechnology · doi:10.1038/nbt.1662 · Cited by 1,075
Diversity and Complexity in DNA Recognition by Transcription Factors
Badis, G., Berger, M., Philippakis, A. A., Talukder, S., Gehrke, A. R., Jaeger, S., Chan, E. T., Metzler, G., Vedenko, A., Chen, X., et al. (2009) · Science · doi:10.1126/science.1162327 · Cited by 1,031
Mathelier, A., Zhao, X., Zhang, A. W., Parcy, F., Worsley-Hunt, R., Arenillas, D. J., Buchman, S., Chen, C., Chou, A., Ienasescu, H., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt997 · Cited by 983
FoxA1 Translates Epigenetic Signatures into Enhancer-Driven Lineage-Specific Transcription
Lupien, M., Eeckhoute, J., Meyer, C. A., Wang, Q., Zhang, Y., Li, W., Carroll, J. S., Liu, X. S., & Brown, M. (2008) · Cell · doi:10.1016/j.cell.2008.01.018 · Cited by 983
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns
John, S., Sabo, P. J., Thurman, R. E., Sung, M.-H., Biddie, S. C., Johnson, T. A., Hager, G. L., & Stamatoyannopoulos, J. A. (2011) · Nature Genetics · doi:10.1038/ng.759 · Cited by 954
Wang, J., Zhuang, J., Iyer, S., Lin, X.-Y., Whitfield, T. W., Greven, M. C., Pierce, B. G., Dong, X., Kundaje, A. B., Cheng, Y., et al. (2012) · Genome Research · doi:10.1101/gr.139105.112 · Cited by 827
PPARγ and C/EBP factors orchestrate adipocyte biology via adjacent binding on a genome-wide scalePreprint
Lefterova, M. I., Zhang, Y., Steger, D. J., Schupp, M., Schug, J., Cristancho, A. G., Feng, D., Zhuo, D. X., Stoeckert, C. J., Liu, X. S., et al. (2008) · Genes & Development · doi:10.1101/gad.1709008 · Cited by 826
Chinenov, Y. V., & Kerppola, T. K. (2001) · Oncogene · doi:10.1038/sj.onc.1204385 · Cited by 723
Melnikov, A., Murugan, A., Zhang, X., Tesileanu, T., Wang, L., Rogov, P., Feizi, S., Gnirke, A., Callan, C. G., Kinney, J. B., et al. (2012) · Nature Biotechnology · doi:10.1038/nbt.2137 · Cited by 711
Self-citationBerman, B. P., Nibu, Y., Pfeiffer, B. D., Tomančák, P., Celniker, S., Levine, M., Rubin, G. M., & Eisen, M. B. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231608898 · Cited by 605
A systems approach to measuring the binding energy landscapes of transcription factors.
Maerkl, S. J., & Quake, S. R. (2007) · Science · doi:10.1126/science.1131007 · Cited by 584
Comparative Epigenomic Analysis of Murine and Human Adipogenesis
Mikkelsen, T. S., Zhao, X. D., Zhang, X., Wang, L., Gimble, J. M., Lander, E. S., & Rosen, E. D. (2010) · Cell · doi:10.1016/j.cell.2010.09.006 · Cited by 538
Self-citationNielsen, R., Pedersen, T. Å., Hagenbeek, D., Moulos, P., Siersbæk, R., Megens, E., Denissov, S., Børgesen, M., Françoijs, K., Mandrup, S., et al. (2008) · Genes & Development · doi:10.1101/gad.501108 · Cited by 520
Distel, R. J., Ro, J., Rosen, B. S., Groves, D. L., & Spiegelman, B. M. (1987) · Cell · doi:10.1016/0092-8674(87)90621-0 · Cited by 506
The myb gene family in cell growth, differentiation and apoptosis
Oh, I.-H., & Reddy, E. P. (1999) · Oncogene · doi:10.1038/sj.onc.1202839 · Cited by 498
Cofactor Binding Evokes Latent Differences in DNA Binding Specificity between Hox Proteins
Slattery, M. G., Riley, T., Liu, P., Abe, N., Gomez-Alcala, P., Dror, I., Zhou, T., Rohs, R., Honig, B. H., Bussemaker, H. J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.10.053 · Cited by 497
Tewhey, R., Kotliar, D., Park, D. S., Liu, B., Winnicki, S., Reilly, S. K., Andersen, K. G., Mikkelsen, T. S., Lander, E. S., Schaffner, S. F., et al. (2016) · Cell · doi:10.1016/j.cell.2016.04.027 · Cited by 480
Self-citationBadis, G., Chan, E. T., van Bakel, H., Peña‐Castillo, L., Tillo, D., Tsui, K., Carlson, C. D., Gossett, A. J., Hasinoff, M. J., Warren, C. L., et al. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.11.020 · Cited by 472
Systematic discovery and characterization of regulatory motifs in ENCODE TF binding experiments
Kheradpour, P., & Kellis, M. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1249 · Cited by 447
Sherwood, R. I., Hashimoto, T., O'Donnell, C. W., Lewis, S., Barkal, A. A., van Hoff, J. P., Karun, V., Jaakkola, T., & Gifford, D. K. (2014) · Nature Biotechnology · doi:10.1038/nbt.2798 · Cited by 429
Regulation of Neuronal Traits by a Novel Transcriptional Complex
Ballas, N., Battaglioli, E., Atouf, F., Andrés, M. E., Chenoweth, J. G., Anderson, M. E., Bürger, C., Moniwa, M., Davie, J., Bowers, W. J., et al. (2001) · Neuron · doi:10.1016/s0896-6273(01)00371-3 · Cited by 416
High-resolution DNA-binding specificity analysis of yeast transcription factorsPreprint
Zhu, C., Byers, K. J. R. P., McCord, R. P., Shi, Z., Berger, M. F., Newburger, D. E., Saulrieta, K., Smith, Z., Shah, M. V., Radhakrishnan, M., et al. (2009) · Genome Research · doi:10.1101/gr.090233.108 · Cited by 402
The histone acetylase PCAF is a nuclear receptor coactivatorPreprint
Blanco, J. C. G., Minucci, S., Lü, J., Yang, X., Walker, K. K., Chen, H., Evans, R. M., Nakatani, Y., & Ozato, K. (1998) · Genes & Development · doi:10.1101/gad.12.11.1638 · Cited by 392
Regulation of Organogenesis by the Caenorhabditis elegans FoxA Protein PHA-4
Gaudet, J., & Mango, S. E. (2002) · Science · doi:10.1126/science.1065175 · Cited by 363
Gordân, R., Shen, N., Dror, I., Zhou, T., Horton, J., Rohs, R., & Bulyk, M. L. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.03.014 · Cited by 361
Siersbæk, R., Nielsen, R., John, S., Sung, M., Baek, S., Loft, A., Hager, G. L., & Mandrup, S. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.65 · Cited by 350
Nucleosome-mediated cooperativity between transcription factors
Mirny, L. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913805107 · Cited by 349
Synergistic activation and repression of transcription by Drosophila homeobox proteins
Han, K., Levine, M., & Manley, J. L. (1989) · Cell · doi:10.1016/0092-8674(89)90580-1 · Cited by 338
Vinson, C. R., Hai, T., & Boyd, S. M. (1993) · Genes & Development · doi:10.1101/gad.7.6.1047 · Cited by 336
Inoue, F., Kircher, M., Martin, B., Cooper, G. M., Witten, D. M., McManus, M. T., Ahituv, N., & Shendure, J. (2017) · Genome Research · doi:10.1101/gr.212092.116 · Cited by 331
Jiang, J. (1993) · Cell · doi:10.1016/0092-8674(93)90402-c · Cited by 327
Kheradpour, P., Ernst, J., Melnikov, A., Rogov, P., Wang, L., Zhang, X., Alston, J., Mikkelsen, T. S., & Kellis, M. (2013) · Genome Research · doi:10.1101/gr.144899.112 · Cited by 315
Self-citationAnimal Transcription Networks as Highly Connected, Quantitative Continua
Biggin, M. D. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.09.008 · Cited by 308
Three Functional Classes of Transcriptional Activation Domains
Blau, J., Xiao, H., McCracken, S. A., O’Hare, P., Greenblatt, J., & Bentley, D. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.5.2044 · Cited by 268
Vallejo, M., Ron, D., Miller, C. P., & Habener, J. F. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.10.4679 · Cited by 266
A Multiparameter Network Reveals Extensive Divergence between C. elegans bHLH Transcription Factors
Grove, C. A., Masi, F. D., Barrasa, M. I., Newburger, D. E., Alkema, M. J., Bulyk, M. L., & Walhout, A. J. M. (2009) · Cell · doi:10.1016/j.cell.2009.04.058 · Cited by 266
A Model for the Cooperative Binding of Eukaryotic Regulatory Proteins to Nucleosomal Target Sites
Polach, K. J., & Widom, J. (1996) · Journal of Molecular Biology · doi:10.1006/jmbi.1996.0288 · Cited by 249
Gotea, V., Visel, A., Westlund, J. M., Nobrega, M. A., Pennacchio, L. A., & Ovcharenko, I. (2010) · Genome Research · doi:10.1101/gr.104471.109 · Cited by 248
Chromatin Landscape Dictates HSF Binding to Target DNA Elements
Guertin, M. J., & Lis, J. T. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001114 · Cited by 244
Atf4 Regulates Obesity, Glucose Homeostasis, and Energy Expenditure
Seo, J. H., Fortuno, E. S., Suh, J. M., Stenesen, D., Tang, W., Parks, E. J., Adams, C. M., Townes, T. M., & Graff, J. M. (2009) · Diabetes · doi:10.2337/db09-0335 · Cited by 244
Cross-talk between glucocorticoid receptor and AP-1
Herrlich, P. A. (2001) · Oncogene · doi:10.1038/sj.onc.1204388 · Cited by 229
Zeitlinger, J., Simon, I., Harbison, C. T., Hannett, N. M., Volkert, T. L., Fink, G. R., & Young, R. A. (2003) · Cell · doi:10.1016/s0092-8674(03)00301-5 · Cited by 224
High-throughput functional testing of ENCODE segmentation predictions
Kwasnieski, J. C., Fiore, C., Chaudhari, H. G., & Cohen, B. A. (2014) · Genome Research · doi:10.1101/gr.173518.114 · Cited by 224
Gelman, L., Zhou, G., Lluis Fajas, A., Raspé, E., Fruchart, J., & Auwerx, J. H. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.12.7681 · Cited by 223
Raveh-Sadka, T., Levo, M., Shabi, U., Shany, B., Keren, L., Lotan‐Pompan, M., Zeevi, D., Sharon, E., Weinberger, A., & Segal, E. (2012) · Nature Genetics · doi:10.1038/ng.2305 · Cited by 221
Sekiya, T., Muthurajan, U. M., Luger, K., Tulin, A. V., & Zaret, K. S. (2009) · Genes & Development · doi:10.1101/gad.1775509 · Cited by 221
Li, X.-Y., Thomas, S., Sabo, P. J., Eisen, M. B., Stamatoyannopoulos, J. A., & Biggin, M. D. (2011) · Genome Biology · doi:10.1186/gb-2011-12-4-r34 · Cited by 217
FOXO-binding partners: it takes two to tango
van der Vos, K. E., & Coffer, P. J. (2008) · Oncogene · doi:10.1038/onc.2008.22 · Cited by 212
Barozzi, I., Simonatto, M., Bonifacio, S., Yang, L., Rohs, R., Ghisletti, S., & Natoli, G. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.04.006 · Cited by 209
White, M. A., Myers, C. A., Corbo, J. C., & Cohen, B. A. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307449110 · Cited by 201
Mitotic Clonal Expansion during Preadipocyte Differentiation: Calpain-mediated Turnover of p27
Patel, Y. M., & Lane, M. D. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m910445199 · Cited by 192
Shemshedini, L., Knauthe, R., Sassone‐Corsi, P., Pornon, A., & Gronemeyer, H. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04953.x · Cited by 188
Functional analysis of transcription factor binding sites in human promoters
Whitfield, T. W., Wang, J., Collins, P. J., Partridge, E. C., Aldred, S. F., Trinklein, N. D., Myers, R., & Weng, Z. (2012) · Genome biology · doi:10.1186/gb-2012-13-9-r50 · Cited by 187
Robertson, A. G., Bilenky, M., Tam, A., Zhao, Y., Zeng, T., Thiessen, N., Cezard, T., Fejes, A. P., Wederell, E. D., Cullum, R., et al. (2008) · Genome Research · doi:10.1101/gr.078519.108 · Cited by 182
Homotypic regulatory clusters in Drosophila.Preprint
Lifanov, A., Makeev, V., Nazina, A., & Papatsenko, D. A. (2003) · Genome Research · doi:10.1101/gr.668403 · Cited by 170
Zaret, K. S., Watts, J. A., Xu, J., Wandzioch, E., Smale, S. T., & Sekiya, T. (2008) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2008.73.040 · Cited by 163
Integrating Diverse Datasets Improves Developmental Enhancer Prediction
Erwin, G. D., Oksenberg, N., Truty, R., Kostka, D., Murphy, K. K., Ahituv, N., Pollard, K. S., & Capra, J. A. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003677 · Cited by 156
Dror, I., Golan, T., Levy, C., Rohs, R., & Mandel‐Gutfreund, Y. (2015) · Genome Research · doi:10.1101/gr.184671.114 · Cited by 149
Selective DNA bending by a variety of bZIP proteins.
Kerppola, T. K., & Curran, T. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.9.5479 · Cited by 146
Unraveling determinants of transcription factor binding outside the core binding sitePreprint
Levo, M., Zalckvar, E., Sharon, E., Machado, A. C. D., Kalma, Y., Lotan‐Pompan, M., Weinberger, A., Zohar Yakhini, B., Rohs, R., & Segal, E. (2015) · Genome Research · doi:10.1101/gr.185033.114 · Cited by 144
Fisher, W. W., Li, J. J., Hammonds, A. S., Brown, J. B., Pfeiffer, B. D., Weiszmann, R., MacArthur, S., Thomas, S., Stamatoyannopoulos, J. A., Eisen, M. B., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209589110 · Cited by 140
Interferon Regulatory Factors Are Transcriptional Regulators of Adipogenesis
Eguchi, J., Yan, Q.-W., Schones, D. E., Kamal, M., Hsu, C.-H., Zhang, M. Q., Crawford, G. E., & Rosen, E. D. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.11.002 · Cited by 132
Waki, H., Nakamura, M., Yamauchi, T., Wakabayashi, K.-I., Yu, J., Hirose, L., Take, K., Sun, W., Iwabu, M., Okada‐Iwabu, M., et al. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002311 · Cited by 129
A proline-rich TGF-beta-responsive transcriptional activator interacts with histone H3.Preprint
Alevizopoulos, A., Dusserre, Y., Tsai-Pflugfelder, M., von der Weid, T., Wahli, W., & Mermod, N. (1995) · Genes & Development · doi:10.1101/gad.9.24.3051 · Cited by 129
Sequence features that drive human promoter function and tissue specificityPreprint
Landolin, J. M., Johnson, D. S., Trinklein, N. D., Aldred, S. F., Medina, C., Shulha, H. P., Weng, Z., & Myers, R. (2010) · Genome Research · doi:10.1101/gr.100370.109 · Cited by 113
Precise temporal control of the eye regulatory gene Pax6 via enhancer-binding site affinityPreprint
Rowan, S., Siggers, T., Lachke, S. A., Yue, Y., Bulyk, M. L., & Maas, R. L. (2010) · Genes & Development · doi:10.1101/gad.1890410 · Cited by 110
Non‐DNA‐binding cofactors enhance DNA‐binding specificity of a transcriptional regulatory complex
Siggers, T., Duyzend, M., Reddy, J., Khan, S., & Bulyk, M. L. (2011) · Molecular Systems Biology · doi:10.1038/msb.2011.89 · Cited by 107
Cell cycle regulation by the B-Myb transcription factor
Joaquin, M., & Watson, R. J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3037-4 · Cited by 102
A chromatin-mediated mechanism for specification of conditional transcription factor targets
Buck, M. J., & Lieb, J. D. (2006) · Nature Genetics · doi:10.1038/ng1917 · Cited by 96
Mechanisms by which transcription factors gain access to target sequence elements in chromatin
Guertin, M. J., & Lis, J. T. (2012) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2012.11.008 · Cited by 85
Simicevic, J., Schmid, A. W., Gilardoni, P. A., Zoller, B., Raghav, S. K., Krier, I., Gubelmann, C., Lisacek, F., Naef, F., Moniatte, M., et al. (2013) · Nature Methods · doi:10.1038/nmeth.2441 · Cited by 83
Self-citationGlobal comparative transcriptome analysis of cartilage formation in vivo
Cameron, T. L., Belluoccio, D., Farlie, P. G., Brachvogel, B., & Bateman, J. F. (2009) · BMC Developmental Biology · doi:10.1186/1471-213x-9-20 · Cited by 81
Cuesta, I., Zaret, K. S., & Santisteban, P. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00758-07 · Cited by 80
Hebbar, P. B., & Archer, T. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.3.887-898.2003 · Cited by 57
Yu, K., Mo, D., Wu, M., Chen, H., Chen, L., Li, M., & Chen, Y. (2014) · FEBS Journal · doi:10.1111/febs.12792 · Cited by 52
Negative Regulation of Chondrocyte Differentiation by Transcription Factor AP-2α
Huang, Z., Xu, H., & Sandell, L. J. (2004) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2004.19.2.245 · Cited by 51
Lee, Y., Kim, S. H., Lee, Y. J., Kang, E. S., Lee, B., Soo, B., Kim, J. W., Song, D. H., & Lee, H. C. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1363-8 · Cited by 50
Dahle, M. K., Grønning, L. M., Cederberg, A., Blomhoff, H. K., Miura, N., Enerbäck, S., Taskén, K. A., & Taskén, K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200131200 · Cited by 49
Purified Cofactors and Histone H1 Mediate Transcriptional Regulation by CTF/NF-I
Dusserre, Y., & Mermod, N. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5228 · Cited by 46
Purified cofactors and histone H1 mediate transcriptional regulation by CTF/NF-I
Dusserre, Y., & Mermod, N. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.11.5228-5237.1992 · Cited by 43
Chromatin Domain Boundaries Delimited by a Histone-binding Protein in Yeast
Ferrari, S., Simmen, K. C., Dusserre, Y., Müller, K., Fourel, G., Gilson, É., & Mermod, N. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410346200 · Cited by 32
Isakova, A., Berset, Y., Vassily Hatzimanikatis, A., & Deplancke, B. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.691154 · Cited by 23
Self-citationIntegrating regulatory information via combinatorial control of the transcription cyclePreprint
Scholes, C., DePace, A. H., & Sánchez, Á. (2016) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/039339 · Cited by 3
Cited by
Sorted by citations
Determinants of enhancer and promoter activities of regulatory elements
Andersson, R., & Sandelin, A. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0173-8 · Cited by 713
Linear models enable powerful differential activity analysis in massively parallel reporter assays
Myint, L., Avramopoulos, D., Goff, L., & Hansen, K. (2017) · BMC Genomics · doi:10.1186/s12864-019-5556-x · Cited by 140
Towards a comprehensive catalogue of validated and target-linked human enhancers
Gasperini, M., Tome, J. M., & Shendure, J. (2020) · Nature Reviews Genetics · doi:10.1038/s41576-019-0209-0 · Cited by 396
Transcription factors: Bridge between cell signaling and gene regulation
Weidemüller, P., Kholmatov, M. M., Petsalaki, E., & Zaugg, J. B. (2021) · PROTEOMICS · doi:10.1002/pmic.202000034 · Cited by 295
DeepSTARR predicts enhancer activity from DNA sequence and enables the de novo design of enhancers
de Almeida, B. P., Reiter, F., Pagani, M., & Stark, A. (2021) · doi:10.1101/2021.10.05.463203 · Cited by 284
Metadata
- Authors
- Grossman, S. R., Zhang, X., Wang, L., Engreitz, J., Melnikov, A., Rogov, P., Tewhey, R., Isakova, A., Deplancke, B., Bernstein, B. E., Mikkelsen, T. S., & Lander, E. S.
- Affiliations
- Broad Institute (US)
- SIB Swiss Institute of Bioinformatics (CH)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-01-30
- Volume
- 114
- Issue
- 7
- Pages
- E1291-E1300
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5321001
- OpenAlex
- W2581468399
- Cited by
- 165
- References
- 101
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 9 · 2023: 14 · 2022: 20 · 2021: 21 · 2020: 23 · 2019: 20 · 2018: 18 · 2017: 10
- FWCI
- 7.93
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion, other-oa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DSpace@MIT (Massachusetts Institute of Technology) (submittedVersion, cc-by-nc)
- Funders
- HHS | NIH | National Human Genome Research Institute (2U54HG003067-10)
- HHS | NIH | National Institute of General Medical Sciences (T32GM007753)
- Office of Extramural Research, National Institutes of Health (R01 HG006785)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- enhancer function, transcription factor binding, PPARγ, transcription factor interaction, chromatin accessibility, binding site affinity, massively parallel reporter assay, synthetic enhancers, adipogenesis, gene expression regulation, human genetic variation
- MeSH terms
- Animals, Binding Sites, Enhancer Elements, Genetic, Gene Expression Regulation, Mutation, Protein Binding, Transcription Factors, Genomics, 3T3-L1 Cells, PPAR gamma, Mice, Nucleotide Motifs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review