The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Systems analysis of protective immune responses to RTS,S malaria vaccination in humans
Open accessAbstract
Significance: The RTS,S malaria vaccine is the most advanced malaria vaccine candidate to be tested in humans. Despite its promise, there is little understanding of its mechanism of action. In this work, we describe the use of a systems biological approach to identify “molecular signatures” that are induced rapidly after the standard RTS,S vaccination regimen, consisting of three RTS,S immunizations, or with a different regimen consisting of a primary immunization with recombinant adenovirus 35 (Ad35) expressing the circumsporozoite malaria antigen followed by two immunizations with RTS,S. These results reveal important insights about the innate and adaptive responses to vaccination and identify signatures of protective immunity against malaria.
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Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625
First Results of Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Children
The RTS, S. C. T. P. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1102287 · Cited by 896
A Phase 3 Trial of RTS,S/AS01 Malaria Vaccine in African Infants
The RTS, S. C. T. P. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1208394 · Cited by 752
Didierlaurent, A. M., Collignon, C., Bourguignon, P., Wouters, S., Fierens, K., Fochesato, M., Dendouga, N., Langlet, C., Malissen, B., Lambrecht, B. N., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400948 · Cited by 266
Cited by
mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases
Maruggi, G., Zhang, C., Li, J., Ulmer, J. B., & Yu, D. (2019) · Molecular Therapy · doi:10.1016/j.ymthe.2019.01.020 · Cited by 507
Vaccination in the elderly: The challenge of immune changes with aging
Ciabattini, A., Nardini, C., Santoro, F., Garagnani, P., Franceschi, C., & Medaglini, D. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.10.010 · Cited by 411
Suscovich, T. J., Fallon, J. K., Das, J., Demas, A. R., Crain, J., Linde, C. H., Michell, A., Natarajan, H., Arevalo, C., Broge, T., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.abb4757 · Cited by 142
Self-citationCurrent Challenges in Vaccinology
Kennedy, R. B., Ovsyannikova, I. G., Palese, P., & Poland, G. A. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01181 · Cited by 113
Immune system development varies according to age, location, and anemia in African children
Hill, D. L., Carr, E. J., Rutishauser, T., Moncunill, G., Campo, J. J., Innocentin, S., Mpina, M., Nhabomba, A., Tumbo, A., Jairoce, C., et al. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw9522 · Cited by 89
Odak, I., Riemann, L., Sandrock, I., Cossmann, A., Ramos, G. M., Hammerschmidt, S. I., Ritter, C., Friedrichsen, M., Hassan, A., Dopfer-Jablonka, A., et al. (2024) · eBioMedicine · doi:10.1016/j.ebiom.2023.104947 · Cited by 17
Metadata
- Authors
- Kazmin, D., Nakaya, H. I., Lee, E. K., Johnson, M. J., van der Most, R., van den Berg, R. A., Ballou, W. R., Jongert, E., Wille-Reece, U., Ockenhouse, C., Aderem, A., Zak, D. E., Sadoff, J., Hendriks, J., Wrammert, J., Ahmed, R., & Pulendran, B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-02-13
- Volume
- 114
- Issue
- 9
- Pages
- 2425-2430
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2588086300
- Cited by
- 293
- References
- 4
- FWCI
- 32.52
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
