Cited by 113vaccines and immunoinformatics approachesImmune responses and vaccinationsSARS-CoV-2 and COVID-19 Research

Current Challenges in Vaccinology

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Kennedy, Richard B., Ovsyannikova, Inna G., Palese, Peter, Poland, Gregory A.·2020·Frontiers in Immunology

Abstract

The development of vaccines, which prime the immune system to respond to future infections, has led to global declines in morbidity and mortality from dreadful infectious communicable diseases. However, many pathogens of public health importance are highly complex and/or rapidly evolving, posing unique challenges to vaccine development. Several of these challenges include an incomplete understanding of how immunity develops, host and pathogen genetic variability, and an increased societal skepticism regarding vaccine safety. In particular, new high-dimensional omics technologies, aided by bioinformatics, are driving new vaccine development (vaccinomics). Informed by recent insights into pathogen biology, host genetic diversity, and immunology, the increasing use of genomic approaches is leading to new models and understanding of host immune system responses that may provide solutions in the rapid development of novel vaccine candidates.

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Crossref · 10.3389/fimmu.2020.01181

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  • Conventional vaccines do not effectively tackle pathogens such as the malaria parasite Plasmodium falciparum, hepatitis C and human immunodeficiency virus (HIV), which evade immune surveillance.

    “Despite their evident success, however, conventional vaccines do not effectively tackle pathogens such as the malaria parasite Plasmodium falciparum, hepatitis C and human immunodeficiency virus (HIV), which evade immune surveillance2.”

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Authors
Kennedy, R. B., Ovsyannikova, I. G., Palese, P., & Poland, G. A.
Affiliations
  • Mayo Clinic (US)
  • Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Kennedy, Richard B.
Venue
Frontiers in Immunology
Published
2020-06-25
Volume
11
Pages
1181-1181
ISSN
1664-3224 (ISSN-L)
OpenAlex
W3033639218
Cited by
113
References
222
Citations by year
2026: 22 · 2025: 24 · 2024: 21 · 2023: 16 · 2022: 12 · 2021: 17 · 2020: 1
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Frontiers in Immunology (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
National Institutes of Health (R01AI033144, R01AI121054, R01AI127365, R01AI132348, R01AI138965, R37AI048793, U01AI089859)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Keywords
vaccine development, vaccinomics, host genetic variation, host immune response, omics technologies, bioinformatics, infectious disease prevention, emerging pathogens
MeSH terms
Vaccinology, Animals, Communicable Disease Control, Humans, Vaccines, Computational Biology

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