The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Nitric oxide negatively regulates mammalian adult neurogenesis
Open accessAbstract
Neural progenitor cells are widespread throughout the adult central nervous system but only give rise to neurons in specific loci. Negative regulators of neurogenesis have therefore been postulated, but none have yet been identified as subserving a significant role in the adult brain. Here we report that nitric oxide (NO) acts as an important negative regulator of cell proliferation in the adult mammalian brain. We used two independent approaches to examine the function of NO in adult neurogenesis. In a pharmacological approach, we suppressed NO production in the rat brain by intraventricular infusion of an NO synthase inhibitor. In a genetic approach, we generated a null mutant neuronal NO synthase knockout mouse line by targeting the exon encoding active center of the enzyme. In both models, the number of new cells generated in neurogenic areas of the adult brain, the olfactory subependyma and the dentate gyrus, was strongly augmented, which indicates that division of neural stem cells in the adult brain is controlled by NO and suggests a strategy for enhancing neurogenesis in the adult central nervous system.
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Gage, F. H. (2000) · Science · doi:10.1126/science.287.5457.1433 · Cited by 4,786
Morshead, C. M., Reynolds, B. A., Craig, C. G., McBurney, M. W., Staines, W. A., Morassutti, D., Weiss, S., & van der Kooy, D. (1994) · Neuron · doi:10.1016/0896-6273(94)90046-9 · Cited by 1,403
Wingrove, J. A., & O'Farrell, P. H. (1999) · Cell · doi:10.1016/s0092-8674(00)80610-8 · Cited by 249
Cited by
Mechanisms and Functional Implications of Adult Neurogenesis
Zhao, C., Deng, W., & Gage, F. H. (2008) · Cell · doi:10.1016/j.cell.2008.01.033 · Cited by 3,007
Butovsky, O., Ziv, Y., Schwartz, A., Landa, G., Talpalar, A. E., Pluchino, S., Martino, G., & Schwartz, M. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.10.006 · Cited by 923
Nuclear factor-κB is a critical mediator of stress-impaired neurogenesis and depressive behavior
Koo, J. W., Russo, S. J., Ferguson, D., Nestler, E. J., & Duman, R. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910658107 · Cited by 607
The Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571
Whitney, N. P., Eidem, T. M., Peng, H., Huang, Y., & Zheng, J. C. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05886.x · Cited by 373
Metadata
- Authors
- Packer, M. A., Stasiv, Y., Benraiss, A., Chmielnicki, E., Grinberg, A., Westphal, H., Goldman, S. A., & Enikolopov, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-07-28
- Volume
- 100
- Issue
- 16
- Pages
- 9566-9571
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2126224335
- Cited by
- 314
- References
- 3
- FWCI
- 5.07
- Type
- journal article
- Language
- en
- Open access
- green
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- Packer, M. A., Stasiv, Y., Benraiss, A., Chmielnicki, E., Grinberg, A., Westphal, H., Goldman, S. A., & Enikolopov, G. (2003). Nitric oxide negatively regulates mammalian adult neurogenesis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1633579100
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