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Mapping of human brown adipose tissue in lean and obese young men
Open accessAbstract
F-labeled fluorodeoxyglucose positron emission tomography/computerized tomography (PET/CT). Obese men had less activated BAT than lean men (mean, 130 vs. 334 mL) but more fat in BAT-containing depots (mean, 1,646 vs. 855 mL) with a wide range (0.1-71%) in the ratio of activated BAT to inactive fat between individuals. Six anatomic regions had activated BAT-cervical, supraclavicular, axillary, mediastinal, paraspinal, and abdominal-with 67 ± 20% of all activated BAT concentrated in a continuous fascial layer comprising the first three depots in the upper torso. These nonsubcutaneous fat depots amounted to 1.5% of total body mass (4.3% of total fat mass), and up to 90% of each depot could be activated BAT. The amount and activity of BAT was significantly influenced by region of interest selection methods, PET threshold criteria, and PET resolutions. The present study suggests that active BAT can be found in specific adipose depots in adult humans, but less than one-half of the fat in these depots is stimulated by acute cold exposure, demonstrating a previously underappreciated thermogenic potential.
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“The role of BAT in adult humans is controversial since its detection is dependent upon the approach employed (Leitner et al., 2017; Porter et al., 2016; van Marken Lichtenbelt et al., 2009).”
From Origin and function of stress-induced IL-6 in murine models (2020) · cites this paper as Leitner et al., 2017
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“A recent study with a refined (18)F-FDG-PET/CT imaging further identified a much wider distribution of (18)F-FDG PETpositive adipocytes than was previously estimated (six locations, including abdominal subcutaneous regions) in adult humans [20].”
Metadata
- Authors
- Leitner, B. P., Huang, S., Brychta, R. J., Duckworth, C. J., Baskin, A. S., McGehee, S., Tal, I., Dieckmann, W., Gupta, G., Kolodny, G. M., Pacak, K., Herscovitch, P., Cypess, A. M., & Chen, K. Y.
- Affiliations
- National Institutes of Health (US)
- Beth Israel Deaconess Medical Center (US)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-07-24
- Volume
- 114
- Issue
- 32
- Pages
- 8649-8654
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5559032
- OpenAlex
- W2736913806
- Cited by
- 530
- References
- 43
- Citations by year
- 2026: 36 · 2025: 45 · 2024: 51 · 2023: 68 · 2022: 73 · 2021: 82 · 2020: 73 · 2019: 45 · 2018: 46 · 2017: 9
- FWCI
- 34.99
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (Z01 DK071014, Z01 DK075116)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- brown adipose tissue, obesity, cold exposure, thermogenesis, BAT activation
- MeSH terms
- Adult, Adipose Tissue, Brown, Humans, Male, Obesity, Tomography, X-Ray Computed, Body Mass Index, Glucose-6-Phosphate, Positron-Emission Tomography, Adiposity
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