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Designing a retrievable and scalable cell encapsulation device for potential treatment of type 1 diabetes
Open accessAbstract
Significance: Cell encapsulation holds great potential as a better treatment for type 1 diabetes. An encapsulation system that is scalable to a clinically relevant capacity and can be retrieved or replaced whenever needed is highly desirable for clinical applications. Here we report a cell encapsulation device that is readily scalable and conveniently retrievable through a minimally invasive laparoscopic procedure. We demonstrated its mechanical robustness and facile mass transfer as well as its durable function in diabetic mice. We further showed, as a proof of concept, its scalability and retrievability in dogs. We believe this encapsulation device may contribute to a cellular therapy for type 1 diabetes and potentially other endocrine disorders and hormone-deficient diseases.
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“Rat islets encapsulated within the device were able to survive and reverse diabetes in immune-competent diabetic mice.”
From Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes (2023) · cites this paper as [101]
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Metadata
- Authors
- An, D., Chiu, A., Flanders, J. A., Song, W., Shou, D., Lu, Y.-C., Grunnet, L. G., Winkel, L., Ingvorsen, C., Christophersen, N. S., Fels, J. J., Sand, F. W., Ji, Y., Qi, L., Pardo, Y., Luo, D., Silberstein, M., Fan, J., & Ma, M.
- Affiliations
- Cornell University (US)
- Novo Nordisk (Denmark) (DK)
- University of Michigan (US)
- Chinese Academy of Sciences (CN)
- ORCID
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2017-12-26
- Volume
- 115
- Issue
- 2
- Pages
- E263-E272
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC5777032
- OpenAlex
- W2776885898
- Cited by
- 200
- References
- 0
- Citations by year
- 2026: 10 · 2025: 10 · 2024: 26 · 2023: 32 · 2022: 22 · 2021: 31 · 2020: 25 · 2019: 32 · 2018: 12
- FWCI
- 19.34
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK020572)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Keywords
- type 1 diabetes, islet transplantation, alginate hydrogel, in situ crosslinking, immunoprotection, retrievability, scalability, human islets, rat islets, cell therapy, C57BL/6 mice, SCID/beige mice
- MeSH terms
- Alginates, Animals, Diabetes Mellitus, Experimental, Dimethylformamide, Dogs, Hexuronic Acids, Humans, Islets of Langerhans, Islets of Langerhans Transplantation, Mice, SCID, Polymethyl Methacrylate, Hydrogels, Glucuronic Acid, Mice, Rats, Cell- and Tissue-Based Therapy
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