The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models
Open accessAbstract
Significance: We have experimentally investigated the immunoregulatory effects of human gut microbiota in multiple sclerosis (MS). We have identified specific bacteria that are associated with MS and demonstrated that these bacteria regulate T lymphocyte-mediated adaptive immune responses and contribute to the proinflammatory environment in vitro and in vivo. Thus, our results expand the knowledge of the microbial regulation of immunity and may provide a basis for the development of microbiome-based therapeutics in autoimmune diseases.
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Citations
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Cited by
Cryan, J. F., O'Riordan, K. J., Cowan, C. S. M., Sandhu, K. V., Bastiaanssen, T. F. S., Boehme, M., Codagnone, M. G., Cussotto, S., Fulling, C., Golubeva, A. V., et al. (2019) · Physiological Reviews · doi:10.1152/physrev.00018.2018 · Cited by 5,286
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The gut microbiota–brain axis in behaviour and brain disorders
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Self-citationThe Controversial Role of Human Gut Lachnospiraceae
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Metadata
- Authors
- Cekanaviciute, E., Yoo, B. B., Runia, T. F., Debelius, J. W., Singh, S., Nelson, C. A., Kanner, R., Bencosme, Y., Lee, Y. K., Hauser, S. L., Crabtree-Hartman, E., Sand, I. K., Gacias, M., Zhu, Y., Casaccia, P., Cree, B. A. C., Knight, R., Mazmanian, S. K., & Baranzini, S. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2017-09-11
- Volume
- 114
- Issue
- 40
- Pages
- 10713-10718
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2750838281
- Cited by
- 1,036
- References
- 11
- FWCI
- 29.70
- Type
- journal article
- Language
- en
- Update notices
- correction (2017-10-09)
- Open access
- bronze
- Funders
- U.S. Department of Defense (W81XWH-15-1-0652)
- IRACDA (K12GM081266)
- National Multiple Sclerosis Society (CA_1072-A-7)
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- The paper
- Cekanaviciute, E., Yoo, B. B., Runia, T. F., Debelius, J. W., Singh, S., Nelson, C. A., Kanner, R., Bencosme, Y., Lee, Y. K., Hauser, S. L., Crabtree-Hartman, E., Sand, I. K., Gacias, M., Zhu, Y., Casaccia, P., Cree, B. A. C., Knight, R., Mazmanian, S. K., & Baranzini, S. E. (2017). Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1711235114
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