The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Modeling the heterogeneity of multiple sclerosis in animals
Open accessAbstract
Multiple sclerosis (MS) is an inflammatory, demyelinating disease of the central nervous system manifested with varying clinical course, pathology, and inflammatory patterns. There are multiple animal models that reflect different aspects of this heterogeneity. Collectively, these models reveal a balance between pathogenic and regulatory CD4+ T cells, CD8+ T cells and B cells that influences the incidence, timing, and severity of central nervous system autoimmunity. In this review we discuss experimental autoimmune encephalomyelitis (EAE) models that have been used to study the pathogenic and regulatory roles of these immune cells, models that recapitulate different aspects of the disease seen in patients with MS, and questions remaining for future studies.
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Cites
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Cited by
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Animal models of multiple sclerosis: From rodents to zebrafish
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Metadata
- Authors
- Simmons, S. B., Pierson, E. R., Lee, S. Y., & Goverman, J. M.
- Venue
- Trends in Immunology
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 34
- Issue
- 8
- Pages
- 410-422
- ISSN
- 1471-4906 (ISSN-L)
- OpenAlex
- W1993662841
- Cited by
- 174
- References
- 23
- FWCI
- 3.20
- Type
- journal article
- Language
- en
- Open access
- green
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- Simmons, S. B., Pierson, E. R., Lee, S. Y., & Goverman, J. M. (2013). Modeling the heterogeneity of multiple sclerosis in animals. Trends in Immunology. https://doi.org/10.1016/j.it.2013.04.006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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