Microbiome of prebiotic-treated mice reveals novel targets involved in host response during obesity
Open accessAbstract
The gut microbiota is involved in metabolic and immune disorders associated with obesity and type 2 diabetes. We previously demonstrated that prebiotic treatment may significantly improve host health by modulating bacterial species related to the improvement of gut endocrine, barrier and immune functions. An analysis of the gut metagenome is needed to determine which bacterial functions and taxa are responsible for beneficial microbiota–host interactions upon nutritional intervention. We subjected mice to prebiotic (Pre) treatment under physiological (control diet: CT) and pathological conditions (high-fat diet: HFD) for 8 weeks and investigated the production of intestinal antimicrobial peptides and the gut microbiome. HFD feeding significantly decreased the expression of regenerating islet-derived 3-gamma (Reg3g) and phospholipase A2 group-II (PLA2g2) in the jejunum. Prebiotic treatment increased Reg3g expression (by ∼50-fold) and improved intestinal homeostasis as suggested by the increase in the expression of intectin, a key protein involved in intestinal epithelial cell turnover. Deep metagenomic sequencing analysis revealed that HFD and prebiotic treatment significantly affected the gut microbiome at different taxonomic levels. Functional analyses based on the occurrence of clusters of orthologous groups (COGs) of proteins also revealed distinct profiles for the HFD, Pre, HFD-Pre and CT groups. Finally, the gut microbiota modulations induced by prebiotics counteracted HFD-induced inflammation and related metabolic disorders. Thus, we identified novel putative taxa and metabolic functions that may contribute to the development of or protection against the metabolic alterations observed during HFD feeding and HFD-Pre feeding.
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Fiber-rich diet seems to promote Akkermansia growth.
“as fiber-rich diet seem to promote Akkermansia growth (Everard et al., 2014).”
From Six-Week Endurance Exercise Alters Gut Metagenome That Is not Reflected in Systemic Metabolism in Over-weight Women (2018) · cites this paper as Everard et al., 2014
Our study corroborates previous studies showing an association between altered diets and an increase in Erysipelotrichi and Allobaculum.
“Our study corroborates previous studies showing an association between altered diets and an increase in Erysipelotrichi and Allobaculum, but various effects are shown for fat-enriched diets 29, 30, 31, 32.”
From The composition of the gut microbiota shapes the colon mucus barrier (2015) · cites this paper as [29]
Tenericutes has been demonstrated to decrease following diet-induced obesity in mice.
“Tenericutes has been demonstrated to decrease following diet-induced obesity in mice [47]”
From Gut microbiota and glucometabolic alterations in response to recurrent partial sleep deprivation in normal-weight young individuals (2016) · cites this paper as [47]
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- Authors
- Everard, A., Lazarevic, V., Gaïa, N., Johansson, M., Ståhlman, M., Backhed, F., Delzenne, N. M., Schrenzel, J., François, P., & Cani, P. D.
- Affiliations
- Walloon Excellence in Lifesciences and Biotechnology (BE)
- Geneva University Hospitals, Division of Infectious Diseases, Genomic Research Lab , Geneva, Switzerland
- University Hospital of Geneva (CH)
- Sahlgrenska University Hospital (SE)
- Wallenberg Laboratory/Sahlgrenska Center for Cardiovascular and Metabolic Research, Sahlgrenska University Hospital , Gothenburg, Sweden
- Corresponding author
- Cani, Patrice D
- Venue
- The ISME Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2014-04-03
- Volume
- 8
- Issue
- 10
- Pages
- 2116-2130
- ISSN
- 1751-7362 (ISSN-L)
- 1751-7370
- PMC
- PMC4163056
- OpenAlex
- W2048853985
- Cited by
- 598
- References
- 54
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 45 · 2023: 53 · 2022: 58 · 2021: 50 · 2020: 75 · 2019: 68 · 2018: 49 · 2017: 55 · 2016: 45 · 2015: 53 · 2014: 7
- FWCI
- 21.85
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- The ISME Journal (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Fonds De La Recherche Scientifique - FNRS
- FP7 Ideas: European Research Council (336452)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Keywords
- prebiotics, gut microbiota, obesity, high-fat diet, Reg3g, intestinal homeostasis, metagenomics, inflammation, metabolic disorders, type 2 diabetes, microbiota-host interactions
- MeSH terms
- Animals, Bacteria, Cecum, Inflammation, Intestinal Mucosa, Membrane Glycoproteins, Mice, Inbred C57BL, Obesity, Peptides, Gastrointestinal Tract, Mice, Metagenome, Prebiotics, Diet, High-Fat, Microbiota
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