Principal cell activity induces spine relocation of adult-born interneurons in the olfactory bulb
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Adult-born neurons adjust olfactory bulb (OB) network functioning in response to changing environmental conditions by the formation, retraction and/or stabilization of new synaptic contacts. While some changes in the odour environment are rapid, the synaptogenesis of adult-born neurons occurs over a longer time scale. It remains unknown how the bulbar network functions when rapid and persistent changes in environmental conditions occur but when new synapses have not been formed. Here we reveal a new form of structural remodelling where mature spines of adult-born but not early-born neurons relocate in an activity-dependent manner. Principal cell activity induces directional growth of spine head filopodia (SHF) followed by spine relocation. Principal cell-derived glutamate and BDNF regulate SHF motility and directional spine relocation, respectively; and spines with SHF are selectively preserved following sensory deprivation. Our three-dimensional model suggests that spine relocation allows fast reorganization of OB network with functional consequences for odour information processing.
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These observations confirm that spine head filopodia induction might trigger spine switching and potentially the replacement of inefficient with more efficient synapses.
“These observations confirm that spine head filopodia induction might trigger spine switching and potentially the replacement of inefficient with more efficient synapses41,42,53.”
From Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction (2018) · cites this paper as [42]
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Self-citationLarge-Scale Models of the Olfactory Bulb
Cavarretta, F. (2022) · Encyclopedia of Computational Neuroscience · doi:10.1007/978-1-0716-1006-0_100664
Self-citationFerreira, A., Constantinescu, V.-S., Malvaut, S., Saghatelyan, A., & Hardy, S. V. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.07.20.549882
Self-citationAdult Neurogenesis Reconciles Flexibility and Stability of Olfactory Perceptual MemoryPreprint
Sakelaris, B. G., & Riecke, H. (2025) · eLife · doi:10.7554/elife.104443.1
Adult Neurogenesis Reconciles Flexibility and Stability of Olfactory Perceptual MemoryPreprint
Sakelaris, B. G., & Riecke, H. (2025) · eLife · doi:10.7554/elife.104443.2
Snapyan, M., Constantinescu, V.-S., Saghatelyan, A., & Parent, M. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1358-24.2025
Self-citationRôle et connectivité des néo-neurones formés à l’âge adulte dans le bulbe olfactif
Grelat, A. (2018) · theses.fr (ABES) · doi:10.70675/c01c4ec0zba51z466aza2f1z09fdd6310b8f
Olfactory learning potentiates long-range cortical GABAergic inputs onto adult-born neuronsPreprint
Peroni, E., Badts, C.-H. D., Lepousez, G., Hiridjee, A., Renvoise, J., Lafosse, I., Wagner, S., Jacquemet, E., Lledo, P., Alonso, M., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.29.728424
- Authors
- Breton-Provencher, V., Bakhshetyan, K., Hardy, D., Bammann, R. R., Cavarretta, F., Snapyan, M., Côté, D., Migliore, M., & Saghatelyan, A.
- Affiliations
- Institut Universitaire en Santé Mentale de Québec (CA)
- University of Milan (IT)
- Corresponding author
- Saghatelyan, Armen
- Venue
- Nature Communications
- Published
- 2016-08-31
- Volume
- 7
- Issue
- 1
- Pages
- 12659-12659
- ISSN
- 2041-1723 (ISSN-L)
- PMC
- PMC5013674
- OpenAlex
- W2517669168
- Cited by
- 60
- References
- 52
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 5 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 5 · 2016: 1
- FWCI
- 3.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Nature Communications (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, cc-by)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Cincinnati Children's Hospital Medical Center
- Helsingin Yliopisto
- Partnership for Advanced Computing in Europe AISBL
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
- Keywords
- adult neurogenesis, olfactory bulb, filopodia, brain-derived neurotrophic factor, glutamate, sensory deprivation, synaptogenesis, network reorganization
- MeSH terms
- Animals, Cell Movement, Female, Image Processing, Computer-Assisted, Interneurons, Male, Mice, Inbred C57BL, Mice, Transgenic, Models, Biological, Odorants, Olfactory Bulb, Pseudopodia, Sensory Deprivation, Smell, Synapses, Glutamic Acid, Brain-Derived Neurotrophic Factor, Models, Animal, Dendritic Spines, Mice, Neurogenesis, Time-Lapse Imaging
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