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Cited by 218Neurogenesis and neuroplasticity mechanismsOlfactory and Sensory Function StudiesNeuroscience and Neuropharmacology Research

Neonatal and adult neurogenesis provide two distinct populations of newborn neurons to the mouse olfactory bulb

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Lemasson, Morgane, Saghatelyan, Armen, Olivo-Marin, Jean-Christophe, Lledo, Pierre-Marie·2005·The Journal of Neuroscience
DOI 10.1523/jneurosci.1114-05.2005PMC PMC6725349
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Abstract

In mammals, the olfactory bulb (OB) constitutes one of two regions of the postnatal brain with continuous neurogenesis throughout life. Despite intense explorations of neuronal replacement in the adult OB, little is known about the mechanisms that operate at earlier postnatal stages. This question is particularly pertinent, because the majority of local interneurons are born in the neonate, when olfaction controls vital functions. Here, we analyzed the recruitment of newborn cells to the granule cell (GC) layer (GCL) and found that the postnatal mouse OB is supplied with two spatiotemporally distinct populations of newborn interneurons. Early born [postnatal day 3 (P3) to P7] GCs constitute a threefold larger population compared with those generated later (P14-P60), and some of them are produced locally within the OB itself. Newborn interneurons generated at P3-P7 were predominantly targeted to the external edge of the GCL, whereas newly generated cells were positioned deeper in older mice. Additionally, although approximately 50% of adult newborn cells were eliminated within a few weeks of reaching the OB, almost the entire population of early born GCs survived until adulthood. Importantly, early olfactory experience specifically modifies the number of newborn GCs in neonates but leaves unaltered the amount of neurons generated during adulthood. Together, these results demonstrate that early postnatal neurogenesis endows the neonate bulbar circuit with newborn GCs that differ morphologically and functionally from those produced in the adult.

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  • Most transduced GCs present in the adult olfactory bulb originate from the early postnatal period.

    “we argue that in our experimental conditions, most of the transduced GCs present in the adult OB originate from the early postnatal period, as this stage is concerned by a proliferation 3-fold larger than in adulthood, and producing GCs with very low cell death if any [14,20,21,55].”

    From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [14]

    The Abstract reports that early-born granule cells form a threefold larger population than later-born cells, and the section ‘Different survival rates of newborn GCs in early and late postnatal neurogenesis’ reports that early-born cells largely survived to adulthood. The paper does not examine transduced cells or establish what fraction of the citing authors’ transduced adult granule cells were born early. (LLM, conf=0.84)

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  • Neonatal-born granule cells have been primarily associated with innate olfactory responses.

    “neonatal-born GCs have been primarily associated with innate olfactory responses [14,20,21,53,54].”

    From Positive early-life olfactory memory is rooted in the olfactory bulb and triggers large-scale changes beyond the olfactory system (2026) · cites this paper as [14]

    The Abstract describes a distinct population of neonatal-born granule cells, and the section ‘Early olfactory experience increases neurogenesis in neonates but not in young adults’ associates those cells with odor experience and a learned, lasting odor preference. The paper does not establish that neonatal-born granule cells are primarily associated with innate olfactory responses. No page number is available in our copy. (LLM, conf=0.83)

    Experimental — accuracy not yet measured

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Authors
Lemasson, M., Saghatelyan, A., Olivo-Marin, J.-C., & Lledo, P.-M.
Affiliations
Centre National de la Recherche Scientifique (FR)
ORCID
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2005-07-20
Volume
25
Issue
29
Pages
6816-6825
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.1114-05.2005
PMC
PMC6725349
OpenAlex
W2031228451
Cited by
218
References
55
Citations by year
2026: 5 · 2025: 9 · 2024: 9 · 2023: 3 · 2022: 4 · 2021: 2 · 2020: 14 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 7 · 2015: 3 · 2014: 16 · 2013: 20 · 2012: 10
FWCI
4.04
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Sensory Systems › Olfactory and Sensory Function Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
olfactory bulb, postnatal neurogenesis, adult neurogenesis, granule cells, olfactory experience, neuronal survival, cell elimination
MeSH terms
Age Factors, Animals, Animals, Newborn, Cell Division, Cell Movement, Interneurons, Male, Mice, Inbred C57BL, Neurons, Olfactory Bulb, Olfactory Pathways, Apoptosis, Mice

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