The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates
Open accessAbstract
Significance: It is well known that cell proliferation, differentiation, and migration depend strongly on the mechanical stiffness of the extracellular matrix (ECM). Natural ECMs also exhibit dissipative (i.e., plastic, viscoelastic) properties, which can modulate cellular behavior. However, to fully utilize this information in bioengineering applications, a systematic understanding of the role of substrate viscosity on cell function is needed. Using combined theoretical and experimental approaches, we demonstrated that viscous dissipation can be as important as elasticity in determining cell response. Specifically, we found that intermediate viscosity maximizes cell spreading on soft substrates, while cell spreading is independent of viscosity on stiff substrates. This information can now be used to design dissipative biomaterials for optimal control of cell behavior.
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Elosegui-Artola, A., Oria, R., Chen, Y., Kosmalska, A., Pérez-González, C., Castro, N., Zhu, C., Trepat, X., & Roca-Cusachs, P. (2016) · Nature Cell Biology · doi:10.1038/ncb3336 · Cited by 858 · cited 14×
“Recent experiments demonstrated that FAs grow on stiff substrates through the recruitment of integrins to the adhesion complex via talin unfolding (20, 21).”
BackgroundInfluentialChoi, C. K., Vicente-Manzanares, M., Zareno, J., Whitmore, L. A., Mogilner, A., & Horwitz, A. R. (2008) · Nature Cell Biology · doi:10.1038/ncb1763 · Cited by 797
Case, L. B., & Waterman, C. M. (2015) · Nature Cell Biology · doi:10.1038/ncb3191 · Cited by 520
PW1/Peg3 expression regulates key properties that determine mesoangioblast stem cell competence
Bonfanti, C., Rossi, G., Tedesco, F. S., Giannotta, M., Benedetti, S., Tonlorenzi, R., Antonini, S., Marazzi, G., Dejana, E., Sassoon, D., et al. (2015) · Nature Communications · doi:10.1038/ncomms7364 · Cited by 101
Cited by
Effects of extracellular matrix viscoelasticity on cellular behaviour
Chaudhuri, O., Cooper-White, J., Janmey, P. A., Mooney, D. J., & Shenoy, V. B. (2020) · Nature · doi:10.1038/s41586-020-2612-2 · Cited by 2,224
Self-citationIntegrins as biomechanical sensors of the microenvironment
Kechagia, J. Z., Ivaska, J., & Roca-Cusachs, P. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0134-2 · Cited by 1,311
Janmey, P. A., Fletcher, D. A., & Reinhart-King, C. A. (2020) · Physiological Reviews · doi:10.1152/physrev.00013.2019 · Cited by 422
Self-citationZhang, K., Feng, Q., Fang, Z., Gu, L., & Bian, L. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.1c00071 · Cited by 394
Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix
Pakshir, P., Alizadehgiashi, M., Wong, B., Coelho, N. M., Chen, X., Gong, Z., Shenoy, V. B., McCulloch, C. A., & Hinz, B. (2019) · Nature Communications · doi:10.1038/s41467-019-09709-6 · Cited by 281
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Metadata
- Authors
- Gong, Z., Szczesny, S. E., Caliari, S. R., Charrier, E. E., Chaudhuri, O., Cao, X., Lin, Y., Mauck, R. L., Janmey, P. A., Burdick, J. A., & Shenoy, V. B.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-03-05
- Volume
- 115
- Issue
- 12
- Pages
- E2686-E2695
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2792015579
- Cited by
- 281
- References
- 4
- FWCI
- 12.99
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gong, Z., Szczesny, S. E., Caliari, S. R., Charrier, E. E., Chaudhuri, O., Cao, X., Lin, Y., Mauck, R. L., Janmey, P. A., Burdick, J. A., & Shenoy, V. B. (2018). Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.1716620115
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