The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Phasic locus coeruleus activity regulates cortical encoding of salience information
Open accessAbstract
Significance: Locus coeruleus (LC) function has been associated with focused attention across species. LC neurons fire tonically or with short phasic bursts. We found that phasic, but not tonic, LC activity produced attentional signals across cortex, including the P300 event-related potential, and revealed distinct long-latency signals in sensory networks. These long-latency signals were seen in subpopulations normally activated by intense or salient stimuli, meaning that phasic LC activation produced salience in sensory neurons. Phasic LC-generated sensory salience signals were tightly temporally regulated, and precisely timed phasic LC activation was able to generate “false salience” in sensory processing networks, in the absence of intense stimuli. Importantly, LC-induced salience signals occurred without changes in arousal, demonstrating independent mechanisms of LC-mediated arousal and attention.
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Berridge, C. W., & Waterhouse, B. D. (2003) · Brain Research Reviews · doi:10.1016/s0165-0173(03)00143-7 · Cited by 2,529
Decision making, the P3, and the locus coeruleus–norepinephrine system
Nieuwenhuis, S., Aston-Jones, G., & Cohen, J. D. (2005) · Psychological Bulletin · doi:10.1037/0033-2909.131.4.510 · Cited by 1,678
Self-citationOrienting and reorienting: the locus coeruleus mediates cognition through arousal
Sara, S. J., & Bouret, S. (2012) · Neuron · doi:10.1016/j.neuron.2012.09.011 · Cited by 1,056
Foote, S. L., Aston-Jones, G., & Bloom, F. E. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.3033 · Cited by 857
Self-citationLocus coeruleus neurons in monkey are selectively activated by attended cues in a vigilance task
Aston-Jones, G., Rajkowski, J., Kubiak, P., & Alexinsky, T. (1994) · The Journal of Neuroscience · doi:10.1523/jneurosci.14-07-04467.1994 · Cited by 637
Self-citationEffects of putative neurotransmitters on neuronal activity in monkey auditory cortex
Foote, S. L., Freedman, R., & Oliver, A. P. (1975) · Brain Research · doi:10.1016/0006-8993(75)90699-x · Cited by 458
Abercrombie, E., & Jacobs, B. (1987) · The Journal of Neuroscience · doi:10.1523/jneurosci.07-09-02837.1987 · Cited by 377
Vazey, E. M., & Aston-Jones, G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310025111 · Cited by 279
Self-citationWaterhouse, B. D., Moises, H. C., & Woodward, D. J. (1980) · Experimental Neurology · doi:10.1016/0014-4886(80)90141-7 · Cited by 209
Effects of locus coeruleus lesions on auditory, long-latency, event-related potentials in monkey
Pineda, J., Foote, S., & Neville, H. (1989) · The Journal of Neuroscience · doi:10.1523/jneurosci.09-01-00081.1989 · Cited by 184
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Poe, G. R., Foote, S., Eschenko, O., Johansen, J. P., Bouret, S., Aston-Jones, G., Harley, C. W., Manahan-Vaughan, D., Weinshenker, D., Valentino, R., et al. (2020) · Nature Reviews Neuroscience · doi:10.1038/s41583-020-0360-9 · Cited by 720
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Noradrenergic Responsiveness Supports Selective Attention across the Adult Lifespan
Dahl, M. J., Mather, M., Sander, M. C., & Werkle-Bergner, M. (2020) · The Journal of Neuroscience · doi:10.1523/jneurosci.0398-19.2020 · Cited by 72
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Metadata
- Authors
- Vazey, E. M., Moorman, D. E., & Aston-Jones, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2018-09-19
- Volume
- 115
- Issue
- 40
- Pages
- E9439-E9448
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2890112730
- Cited by
- 242
- References
- 12
- FWCI
- 6.49
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
