Activation of orexin system facilitates anesthesia emergence and pain control

Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior

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The hypocretins: hypothalamus-specific peptides with neuroexcitatory activity

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Neurons containing hypocretin (orexin) project to multiple neuronal systems

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The Sleep Disorder Canine Narcolepsy Is Caused by a Mutation in the Hypocretin (Orexin) Receptor 2 Gene

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Hypocretin (orexin) deficiency in human narcolepsy

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General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

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Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems

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Chemogenetics revealed: DREADD occupancy and activation via converted clozapine

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Excitation of Ventral Tegmental Area Dopaminergic and Nondopaminergic Neurons by Orexins/Hypocretins

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General anesthetic actions <i>in vivo</i> strongly attenuated by a point mutation in the GABA _A receptor β3 subunit

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Presynaptic and Postsynaptic Actions and Modulation of Neuroendocrine Neurons by a New Hypothalamic Peptide, Hypocretin/Orexin

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Hypothalamic Hypocretin (Orexin): Robust Innervation of the Spinal Cord

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Sympathetic and cardiovascular actions of orexins in conscious rats

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Hypocretins (Orexins) Regulate Serotonin Neurons in the Dorsal Raphe Nucleus by Excitatory Direct and Inhibitory Indirect Actions

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Distinct Functional and Pharmacological Properties of Tonic and Quantal Inhibitory Postsynaptic Currents Mediated by γ-Aminobutyric AcidAReceptors in Hippocampal Neurons

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An essential role for orexins in emergence from general anesthesia

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Orexins/hypocretins excite basal forebrain cholinergic neurones

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Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive

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Designer receptor manipulations reveal a role of the locus coeruleus noradrenergic system in isoflurane general anesthesia

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Optogenetic activation of dopamine neurons in the ventral tegmental area induces reanimation from general anesthesia

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Analgesic effect of intrathecally administered orexin‐A in the rat formalin test and in the rat hot plate test

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Orexins (hypocretins) directly excite tuberomammillary neurons

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Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP‐expressing locus coeruleus

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Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models

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General anaesthetic action at transmitter-gated inhibitory amino acid receptors

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Concurrent and robust regulation of feeding behaviors and metabolism by orexin neurons

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Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients

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Orexin (Hypocretin) Receptor Agonists and Antagonists for Treatment of Sleep Disorders

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Respiratory and cardiovascular actions of orexin-A in mice

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GABAA receptor subtypes underlying general anesthesia

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Orexin/hypocretin treatment restores hippocampal-dependent memory in orexin-deficient mice

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Dexmedetomidine Prevents Excessive γ-Aminobutyric Acid Type A Receptor Function after Anesthesia

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Effects of orexin-A on propofol anesthesia in rats

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Orexin-A Facilitates Emergence from Propofol Anesthesia in the Rat

Zhang, L.-N., Li, Z.-J., Li, T., Guo, C., Niu, J., Hou, W., & Dong, H. (2012) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e3182645ea3 · Cited by 59 · see citing works

The dual role of the orexin/hypocretin system in modulating wakefulness and respiratory drive

Gestreau, C., Bévengut, M., & Dutschmann, M. (2008) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0b013e32831311d3 · Cited by 55 · see citing works

Activation of orexin signal in basal forebrain facilitates the emergence from sevoflurane anesthesia in rat

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Orexin A Decreases Ketamine-Induced Anesthesia Time in the Rat: The Relevance to Brain Noradrenergic Neuronal Activity

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Optogenetic Control of Hypocretin (Orexin) Neurons and Arousal Circuits

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GABA A receptor membrane trafficking regulates spine maturity

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Hypothalamic Modulation of Breathing

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The Neuropeptide Orexin-A Inhibits the GABAA Receptor by PKC and Ca2+/CaMKII-Dependent Phosphorylation of Its β1 Subunit

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Central orexin-A increases gastric motility in rats

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Thermosensing mechanisms and their impairment by high-fat diet in orexin neurons

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Orexin a phosphorylates the γ‐Aminobutyric acid type A receptor β2 subunit on a serine residue and changes the surface expression of the receptor in SH‐SY5Y cells exposed to propofol

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Closing the Gap Between the Molecular and Systemic Actions of Anesthetic Agents

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Untitled work

Horvath (1999) · doi:10.1002/(sici)1096-9861(19991213)415:2

Towards a comprehensive understanding of anesthetic mechanisms of action: a decade of discovery

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The Biology of General Anesthesia from Paramecium to Primate

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Postnatal maturation of spinal dynorphin circuits and their role in somatosensation

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Feeding and activity induced by orexin A in the lateral hypothalamus in rats

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Feeding response to central orexins

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[Expression of orexin A, orexin receptor-1, and Ob-R of hypothalamus in rats with chronic renal failure].

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Cardiovascular pressor effects of orexins in the dorsomedial hypothalamus

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A role for lateral hypothalamic orexin neurons in reward seeking

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