Cited by 68Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsDementia and Cognitive Impairment Research

Blood-derived plasminogen drives brain inflammation and plaque deposition in a mouse model of Alzheimer’s disease

Open access
Baker, Sarah K., Chen, Zu-Lin, Norris, Erin H., Revenko, Alexey S., MacLeod, A. Robert, Strickland, Sidney·2018·Proceedings of the National Academy of Sciences

Abstract

Significance: We demonstrate that depletion of blood plasminogen is sufficient to protect against both innate immune cell activation in the brain and Alzheimer’s disease (AD) pathology in a mouse model of AD. This work provides a molecular mechanism for initiation of AD-related brain inflammation and for regulation of β-amyloid deposition, and could lead to therapeutic strategies in human AD patients, including the targeting of systemic molecules.

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Registry

Crossref · 10.1073/pnas.1811172115

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73 of 73 references verified0 citation errors · 0 not checkable

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Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • The benefits of GPLD1 and other exerkines on brain structure and function may relate to peripheral effects such as complement signalling or coagulation.

    “Hence, the benefit of GPLD1 (REF.148) and other exerkines on brain structure and function might relate to its peripheral effects, such as the complement signalling cascade149,158, or coagulation159.”

    From Exerkines in health, resilience and disease (2022) · cites this paper as [159]

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Authors
Baker, S. K., Chen, Z.-L., Norris, E. H., Revenko, A. S., MacLeod, A. R., & Strickland, S.
Affiliations
  • Rockefeller University (US)
  • Ionis Pharmaceuticals (United States) (US)
Venue
Proceedings of the National Academy of Sciences
Published
2018-09-25
Volume
115
Issue
41
Pages
E9687-E9696
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2893444607
Cited by
68
References
74
Citations by year
2026: 4 · 2025: 6 · 2024: 3 · 2023: 11 · 2022: 4 · 2021: 17 · 2020: 14 · 2019: 8 · 2018: 1
FWCI
6.88
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
HHS | NIH | National Institute of Neurological Disorders and Stroke (NS106668)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
Alzheimer's disease, plasminogen, plasmin, neuroinflammation, amyloid plaques, antisense oligonucleotides, alpha2-antiplasmin, glial activation, systemic inflammation, mouse models of Alzheimer's disease
MeSH terms
Alzheimer Disease, Animals, Brain, Disease Models, Animal, Inflammation, Mice, Transgenic, Plasminogen, Amyloid beta-Peptides, Oligodeoxyribonucleotides, Antisense, Mice

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