Cited by 228Epigenetics and DNA MethylationStress Responses and CortisolBirth, Development, and Health

The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.

Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing changes in DNA methylation

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Abstract

Significance: Prenatal stress exposure is associated with a wide range of health problems later in life. This may be mediated in part via glucocorticoid (GC) exposure during fetal development known to impact neurogenesis and induce epigenetic changes. Using a human fetal hippocampal progenitor cell line to assess the effects of GCs, we observe that exposure to GCs early during neurogenesis results in lasting changes in DNA methylation (DNAm). Lasting DNAm alterations are associated with significantly enhanced transcriptional response to a subsequent GC exposure. Our data suggest that early exposure to GCs changes the set point of future transcriptional responses to stress by inducing lasting DNAm changes. Such altered set points may relate to differential vulnerability to stress exposure later in life.

Overview

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Crossref · 10.1073/pnas.1820842116

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37 of 37 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 1

  1. N. Provencal . Glucocorticoid exposure during hippocampal neurogenesis primes future stress response by inducing long-lasting changes in DNA methylation. Gene Expression Omnibus. https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE119847. Deposited 12 September 2018.

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Metadata

Authors
Provençal, N., Arloth, J., Cattaneo, A., Anacker, C., Cattane, N., Wiechmann, T., Röh, S., Ködel, M., Klengel, T., Czamara, D., Müller, N. S., Lahti, J., PREDO team, Räikkönen, K., Pariante, C. M., Binder, E. B., Kajantie, E., Hämäläinen, E., Villa, P., & Laivuori, H.
Affiliations
  • Simon Fraser University (CA)
  • Helmholtz Munich (DE)
  • King's College London (GB)
  • Research Foundation For Mental Hygiene (US)
  • Centro San Giovanni di Dio Fatebenefratelli (IT)
  • Max Planck Institute of Psychiatry (DE)
  • Harvard University (US)
  • University of Helsinki (FI)
  • Emory University (US)
Venue
Proceedings of the National Academy of Sciences
Published
2019-08-09
Volume
117
Issue
38
Pages
23280-23285
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2968811349
Cited by
209
References
37
Citations by year
2026: 16 · 2025: 22 · 2024: 32 · 2023: 34 · 2022: 28 · 2021: 46 · 2020: 24 · 2019: 7
FWCI
10.17
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • Työväentutkimus Vuosikirja (submittedVersion)
  • Site cant be reached (submittedVersion, other-oa)
  • GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
Funders
  • National Institute for Health and Care Research (NIHR201376, NF-SI-0616-10074)
  • Canadian Institutes of Health Research
  • Medical Research Council (MR/N029488/1)
  • National Institute of Mental Health (K99MH108719, R00MH108719)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (R21HD088931)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords
glucocorticoids, prenatal stress, hippocampal neurogenesis, DNA methylation, epigenetics, hippocampal progenitor cells, stress response, differentially methylated sites, umbilical cord blood, mental illness, fetal brain development
MeSH terms
Female, Gene Expression Regulation, Glucocorticoids, Hippocampus, Humans, Male, Pregnancy, Prenatal Exposure Delayed Effects, Stress, Physiological, Cohort Studies, DNA Methylation, Neurogenesis

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