Cited by 377Liver physiology and pathologyCardiovascular Conditions and TreatmentsToxic Organic Pollutants Impact

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Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice

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Lahvis, Garet P., Lindell, Susanne L., Thomas, Russell S., McCuskey, Robert S., Murphy, Christopher, Glover, Edward, Bentz, Michael, Southard, James, Bradfield, Christopher A.·2000·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.190256997PMC PMC27043

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Abstract

A physiological examination of mice harboring a null allele at the aryl hydrocarbon ( Ah ) locus revealed that the encoded aryl hydrocarbon receptor plays a role in the resolution of fetal vascular structures during development. Although the aryl hydrocarbon receptor is more commonly studied for its role in regulating xenobiotic metabolism and dioxin toxicity, a developmental role of this protein is supported by the observation that Ah null mice display smaller livers, reduced fecundity, and decreased body weights. Upon investigating the liver phenotype, we found that the decrease in liver size is directly related to a reduction in hepatocyte size. We also found that smaller hepatocyte size is the result of massive portosystemic shunting in null animals. Colloidal carbon uptake and microsphere perfusion studies indicated that 56% of portal blood flow bypasses the liver sinusoids. Latex corrosion casts and angiography demonstrated that shunting is consistent with the existence of a patent ductus venosus in adult animals. Importantly, fetal vascular structures were also observed at other sites. Intravital microscopy demonstrated an immature sinusoidal architecture in the liver and persistent hyaloid arteries in the eyes of adult Ah null mice, whereas corrosion casting experiments described aberrations in kidney vascular patterns.

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Authors: Lahvis, G. P., Lindell, S. L., Thomas, R. S., McCuskey, R. S., Murphy, C., Glover, E., Bentz, M., Southard, J., & Bradfield, C. A.
Affiliations: University of Wisconsin–Madison (US)
Corresponding author: Bradfield, Christopher A.
ORCID: Lahvis, Garet P.
Thomas, Russell S.
Bradfield, Christopher A.
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 2000-09-05
Volume: 97
Issue: 19
Pages: 10442-10447
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.190256997
PMC: PMC27043
OpenAlex: W2163212976
Cited by: 377
References: 53
Citations by year: 2026: 5 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 13 · 2020: 7 · 2019: 8 · 2018: 14 · 2017: 10 · 2016: 14 · 2015: 8 · 2014: 11 · 2013: 13 · 2012: 19
FWCI: 12.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Burroughs Wellcome Fund
Colgate-Palmolive Company
National Institutes of Health (5p30ca007175-36, CA22484)
National Cancer Institute (CA-07175, T32CA009681, CA 22484, P01CA022484)
National Institute of Environmental Health Sciences (ES06883, F32ES005877, R01ES006883)
Topics: Health Sciences › Medicine › Hepatology › Liver physiology and pathology
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
Keywords: aryl hydrocarbon receptor, portosystemic shunt, patent ductus venosus, hyaloid artery, liver development, hepatocyte size, dioxin toxicity
MeSH terms: Animals, Arteries, Eye, Female, Kidney, Liver, Male, Mice, Inbred C57BL, Organ Size, Receptors, Aryl Hydrocarbon, Mice

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Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice

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