The DOI matches its Crossref record; 51 of the 53 references it cites were found in a registry or an index.
Portosystemic shunting and persistent fetal vascular structures in aryl hydrocarbon receptor-deficient mice
Open accessAbstract
A physiological examination of mice harboring a null allele at the aryl hydrocarbon ( Ah ) locus revealed that the encoded aryl hydrocarbon receptor plays a role in the resolution of fetal vascular structures during development. Although the aryl hydrocarbon receptor is more commonly studied for its role in regulating xenobiotic metabolism and dioxin toxicity, a developmental role of this protein is supported by the observation that Ah null mice display smaller livers, reduced fecundity, and decreased body weights. Upon investigating the liver phenotype, we found that the decrease in liver size is directly related to a reduction in hepatocyte size. We also found that smaller hepatocyte size is the result of massive portosystemic shunting in null animals. Colloidal carbon uptake and microsphere perfusion studies indicated that 56% of portal blood flow bypasses the liver sinusoids. Latex corrosion casts and angiography demonstrated that shunting is consistent with the existence of a patent ductus venosus in adult animals. Importantly, fetal vascular structures were also observed at other sites. Intravital microscopy demonstrated an immature sinusoidal architecture in the liver and persistent hyaloid arteries in the eyes of adult Ah null mice, whereas corrosion casting experiments described aberrations in kidney vascular patterns.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Mice null for Ahr exhibit a patent DV with 100% penetrance, though the AHR-driven genes responsible for shunt closer remain unknown.”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Lahvis et al., 2000
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“The patent DV is one of the most easily assessed and penetrant AHR-mediated phenotypes (Harstad et al., 2006; Lahvis et al., 2000; Lahvis et al., 2005).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Lahvis et al., 2000
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Early characterization of these null mice from our own laboratory uncovered significant vascular phenotypes, including the patent ductus venosus (DV) in the liver and a hyaloid artery in the eye, both of which are normal fetal structures that typically resolve shortly after birth (Lahvis et al., 2000; Lahvis et al., 2005; J. V. Schmidt et al., 1996).”
From Rodent Genetic Models of Ah Receptor Signaling (2021) · cites this paper as Lahvis et al., 2000
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
Carmeliet, P., Dor, Y., Herbert, J.-M., Fukumura, D., Brusselmans, K., Dewerchin, M., Neeman, M., Bono, F., Abramovitch, R., Maxwell, P., et al. (1998) · Nature · doi:10.1038/28867 · Cited by 2,502
A Survey of Exact Inference for Contingency Tables
Agresti, A. (1992) · Statistical Science · doi:10.1214/ss/1177011454 · Cited by 1,132
Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8104 · Cited by 1,084
Immune System Impairment and Hepatic Fibrosis in Mice Lacking the Dioxin-Binding Ah Receptor
Fernandez-Salguero, P., Pineau, T., Hilbert, D. M., McPhail, T., Lee, S. S. T., Kimura, S., Nebert, D. W., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1995) · Science · doi:10.1126/science.7732381 · Cited by 1,075
The PAS Superfamily: Sensors of Environmental and Developmental Signals
Gu, Y.-Z., Hogenesch, J. B., & Bradfield, C. A. (2000) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.40.1.519 · Cited by 1,044
Self-citationCloning of a Factor Required for Activity of the Ah (Dioxin) Receptor
Hoffman, E. C., Reyes, H., Chu, F., Sander, F. C., Conley, L. H., Brooks, B. A., & Hankinson, O. (1991) · Science · doi:10.1126/science.1852076 · Cited by 958
Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C., & Bradfield, C. A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6731 · Cited by 902
Self-citationFernández‐Salguero, P. M., Hilbert, D. M., Rudikoff, S., Ward, J. M., & Gonzalez, F. J. (1996) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1996.0210 · Cited by 835
Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.
Burbach, K. M., Poland, A., & Bradfield, C. A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.17.8185 · Cited by 831
Self-citationMaltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature · doi:10.1038/386403a0 · Cited by 781
Self-citationReyes, H., Reisz‐Porszasz, S., & Hankinson, O. (1992) · Science · doi:10.1126/science.256.5060.1193 · Cited by 777
Mimura, J., Yamashita, K., Nakamura, K., Morita, M., Takagi, T. N., Nakao, K., Ema, M., Sogawa, K., Yasuda, M., Katsuki, M., et al. (1997) · Genes to Cells · doi:10.1046/j.1365-2443.1997.1490345.x · Cited by 626
Kotch, L. E., Iyer, N. V., Laughner, E., & Semenza, G. L. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9253 · Cited by 422
cDNA cloning and structure of mouse putative Ah receptor
Ema, M., Sogawa, K., Watanabe, N., Chujoh, Y., Matsushita, N., Gotoh, O., Funae, Y., & Fujii-Kuriyama, Y. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91185-s · Cited by 395
Pitot, H. C., Goldsworthy, T. L., Campbell, H. A., & Poland, A. (1980) · PubMed · Cited by 372
Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse
Jain, S., Maltepe, E., Lu, M. M., Simon, C., & Bradfield, C. A. (1998) · Mechanisms of Development · doi:10.1016/s0925-4773(98)00038-0 · Cited by 333
Self-citationARNT-Deficient Mice and Placental Differentiation
Kozak, K. R., Abbott, B., & Hankinson, O. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8758 · Cited by 328
Mutations in TFAP2B cause Char syndrome, a familial form of patent ductus arteriosus
Satoda, M., Zhao, F., Díaz, G. A., Burn, J., Goodship, J., Davidson, H. R., Pierpont, M. E., & Gelb, B. D. (2000) · Nature Genetics · doi:10.1038/75578 · Cited by 261
Oxygen and the Growth and Development of Retinal Vessels
Ashton, N. (1966) · American Journal of Ophthalmology · doi:10.1016/0002-9394(66)91322-5 · Cited by 260
In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.
Dolwick, K. M., Swanson, H. I., & Bradfield, C. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8566 · Cited by 239
Self-citationMeasurement of portal–systemic shunting in the rat by using gamma-labeled microspheres
Chojkier, M., & Groszmann, R. J. (1981) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1981.240.5.g371 · Cited by 239
Amelioration of TCDD-induced teratogenesis in aryl hydrocarbon receptor (AhR)-null mice
Peters, J., Narotsky, M. G., Elizondo, G., Fernández‐Salguero, P. M., Gonzalez, F. J., & Abbott, B. D. (1999) · Toxicological Sciences · doi:10.1093/toxsci/47.1.86 · Cited by 232
Adverse Reproductive Outcomes in the Transgenic Ah Receptor-Deficient Mouse
Abbott, B. D., Schmid, J. E., Pitt, J. A., Buckalew, A. R., Wood, C. R., Held, G. A., & Diliberto, J. J. (1999) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1998.8601 · Cited by 219
Liver regeneration in recipients and donors after transplantation
Kawasaki, S., Makuuchi, M., Ishizone, S., Matsunami, H., Terada, M., & Kawarazaki, H. (1992) · The Lancet · doi:10.1016/0140-6736(92)90867-3 · Cited by 208
A Guide to Practical Stereology
Williams, M. A. (1984) · Europe PMC (PubMed Central) · Cited by 166
Hahn, M. E., Poland, A., Glover, E., & Stegeman, J. J. (1994) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1994.1160 · Cited by 156
Self-citationahr null alleles: distinctive or different?
Lahvis, G. P., & Bradfield, C. A. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(98)00134-8 · Cited by 152
Self-citationA Guide to Practical Stereology
Elias, H., & Hyde, D. M. (1983) · KARGER eBooks · doi:10.1159/isbn.978-3-8055-3466-6 · Cited by 147
Maltepe, E., & Simon, M. C. (1998) · Journal of Molecular Medicine · doi:10.1007/s001090050231 · Cited by 131
2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Induced Changes In Immunocompetence : Possible Mechanisms
Holsapple, M. P., Morris, D. L., Wood, S. C., & Snyder, N. K. (1991) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.31.040191.000445 · Cited by 129
Kam, I., Lynch, S., Svanas, G. W., Todo, S., Polimeno, L., Francavilla, A., Penkrot, R. J., Takaya, S., Ericzon, B. G., Starzl, T. E., et al. (1987) · Hepatology · doi:10.1002/hep.1840070225 · Cited by 128
Chlorpyrifos elicits mitotic abnormalities and apoptosis in neuroepithelium of cultured rat embryos
Roy, T. S., Andrews, J. E., Seidler, F. J., & Slotkin, T. A. (1998) · Teratology · doi:10.1002/(sici)1096-9926(199808)58:2 · Cited by 123
Effect of starvation on the composition of the liver cell
Harrison, M. F. (1953) · Biochemical Journal · doi:10.1042/bj0550204 · Cited by 123
Telakowski-Hopkins, C. A., King, R. G., & Pickett, C. B. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.4.1000 · Cited by 118
Optical microscopy: emerging methods and applications
Fricker, M. D. (1993) · FEBS Letters · doi:10.1016/0014-5793(93)80466-8 · Cited by 114
Optical microscopy : emerging methods and applications
Herman, B. A., & Lemasters, J. J. (1993) · Cited by 93
Uchino, T., Endo, F., Ikeda, S., Shiraki, K., Sera, Y., & Matsuda, I. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8964424 · Cited by 92
Characterization of Hepatoportal Microvascular Dysplasia in a Kindred of Cairn Terriers
Schermerhorn, T., Dykes, N. L., Rowland, P. H., Yeager, A. E., Erb, H. N., Oberhansley, K., & Bonda, M. (1996) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.1996.tb02053.x · Cited by 71
Cowper, K., Currin, R. T., Dawson, T. L., LINDERT, K. A., Lemasters, J. J., & Thurman, R. G. (1990) · Biochemical Journal · doi:10.1042/bj2660141 · Cited by 67
Eisen, H. J., Hannah, R. R., Legraverend, C., Okey, A. B., & Nebert, D. W. (1983) · Biochemical Actions of Hormones · doi:10.1016/b978-0-12-452810-9.50012-7 · Cited by 65
Huuskonen, H., Unkila, M., Pohjanvirta, R., & Tuomisto, J. T. (1994) · Toxicology and Applied Pharmacology · doi:10.1006/taap.1994.1021 · Cited by 62
Arylhydrocarbon receptor expression in the human endometrium
Küchenhoff, A., Seliger, G., Klonisch, T. C., Tscheudschilsuren, G., Kaltwaßer, P., Seliger, E., Buchmann, J., & Fischer, B. (1999) · Fertility and Sterility · doi:10.1016/s0015-0282(98)00437-3 · Cited by 51
Hepatic manifestations of familial patent ductus venosus in adults
Jacob, S., Farr, G., Vun, D. D., Takiff, H., & Mason, A. L. (1999) · Gut · doi:10.1136/gut.45.3.442 · Cited by 50
The portacaval and splenocaval shunt in the normal rat
Schröder, R., Müller, O. M., & Bircher, J. (1985) · Journal of Hepatology · doi:10.1016/s0168-8278(85)80760-1 · Cited by 43
(1988) · PubMed · Cited by 31
Effect of dietary state on hepatocyte size
Uhal, B. D., & Roehrig, K. L. (1982) · Bioscience Reports · doi:10.1007/bf01122168 · Cited by 25
Healey, J. E. (1970) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1970.tb37000.x · Cited by 25
Hyaloid Vascular Pattern in the Human Fetus
Ko, M.-K., Je, G., & Chang, B.-L. (1985) · Journal of Pediatric Ophthalmology & Strabismus · doi:10.3928/0191-3913-19850901-07 · Cited by 17
[38] Use of gel retardation to analyze protein-DNA interactions upstream of CYPIA1 gene
Shen, E. S., Elferink, C. J., & Whitlock, J. P. (1991) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(91)06109-g · Cited by 15
Resistance to Reinfection in Experimental Murine Schistosomiasis: Role of Porto-Hepatic Hemodynamics
Pons, H., Morgan, J. S., Hutchinson, M. L., Rojkind, M., Groszmann, R. J., & Stadecker, M. J. (1989) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.1989.41.189 · Cited by 10
Hepatocyte ultrastructure in the rat after long term portacaval anastomosis: a morphometric study.
Dubuisson, L., Bioulac‐Sage, P., Bedin, C., & Balabaud, C. (1984) · PubMed · Cited by 8
Research works printed but not linked: 7
- H C Pitot, T Goldsworthy, H A Campbell, A Poland Cancer Res 40, 3616–3620 (1980).
- M Chojkier, R J Groszmann Am J Physiol 240, G371–G375 (1981).
- A Agresti Stat Sci 7, 131–135 (1992).
- A Francavilla, P Ove, L Polimeno, M Coetzee, L Makowka, M Barone, D H Van Thiel, T E Starzl Transplant Proc 20, 494–497 (1988).
- L Dubuisson, P Bioulac-Sage, C Bedin, C Balabaud J Submicrosc Cytol 16, 283–287 (1984).
- R S McCuskey, W Ekataksin, A V LeBouton, J Nishida, M A Krasovich, D McDonnell, C Williams, O Koldovsky Cells of the Hepatic Sinusoid VI, eds E Wisse, D L Knook, C Balabaud (Kupffer Cell Foundation, Leiden), pp. 67–70 (1997).
- Y-Z Gu, J Hogenesch, C Bradfield Annu. Rev. Pharmacol. Toxicol. (Academic Press), pp. 519–561 (2000).
Cited by
Sorted by citations
Denison, M. S., & Nagy, S. R. (2003) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pharmtox.43.100901.135828 · Cited by 1,895
Nebert, D. W., Dalton, T. P., Okey, A. B., & Gonzalez, F. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.r400004200 · Cited by 1,211
The aryl hydrocarbon receptor: multitasking in the immune system
Stockinger, B., Meglio, P. D., Gialitakis, M., & Duarte, J. H. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120245 · Cited by 909
Functional role of AhR in the expression of toxic effects by TCDD
Mimura, J., & Fujii‐Kuriyama, Y. (2003) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00485-3 · Cited by 754
The Search for Endogenous Activators of the Aryl Hydrocarbon Receptor
Nguyen, L. P., & Bradfield, C. A. (2007) · Chemical Research in Toxicology · doi:10.1021/tx7001965 · Cited by 718
Self-citation
Metadata
- Authors
- Lahvis, G. P., Lindell, S. L., Thomas, R. S., McCuskey, R. S., Murphy, C., Glover, E., Bentz, M., Southard, J., & Bradfield, C. A.
- Affiliations
- University of Wisconsin–Madison (US)
- Corresponding author
- Bradfield, Christopher A.
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2000-09-05
- Volume
- 97
- Issue
- 19
- Pages
- 10442-10447
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC27043
- OpenAlex
- W2163212976
- Cited by
- 377
- References
- 53
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 4 · 2023: 8 · 2022: 12 · 2021: 13 · 2020: 7 · 2019: 8 · 2018: 14 · 2017: 10 · 2016: 14 · 2015: 8 · 2014: 11 · 2013: 13 · 2012: 19
- FWCI
- 12.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Burroughs Wellcome Fund
- Colgate-Palmolive Company
- National Institutes of Health (5p30ca007175-36, CA22484)
- National Cancer Institute (CA-07175, T32CA009681, CA 22484, P01CA022484)
- National Institute of Environmental Health Sciences (ES06883, F32ES005877, R01ES006883)
- Topics
- Health Sciences › Medicine › Hepatology › Liver physiology and pathology
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Cardiovascular Conditions and Treatments
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Toxic Organic Pollutants Impact
- Keywords
- aryl hydrocarbon receptor, portosystemic shunt, patent ductus venosus, hyaloid artery, liver development, hepatocyte size, dioxin toxicity
- MeSH terms
- Animals, Arteries, Eye, Female, Kidney, Liver, Male, Mice, Inbred C57BL, Organ Size, Receptors, Aryl Hydrocarbon, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
