The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations
Open accessAbstract
A genomewide screen of a collection of 4,847 yeast gene deletion mutants was carried out to identify the genes required for suppressing mutations in the CAN1 forward-mutation assay. The primary screens and subsequent analysis allowed ( i ) identification of 18 known mutator mutants, providing a solid means for checking the efficiency of the screen, and ( ii ) identification of a number of genes not known previously to be involved in suppressing mutations. Among the previously uncharacterized mutation-suppressing genes were six genes of unknown function including four ( CSM2 , SHU2 , SHU1 , and YLR376c ) encoding proteins that interact with each other and promote resistance to killing by methyl methanesulfonate, one gene ( EGL1 ) previously identified as suppressing Ty1 mobility and recombination between repeated sequences, and one gene ( YLR154c ) that was not associated with any known processes. In addition, five genes ( TSA1 , SOD1 , LYS7 , SKN7 , and YAP1 ) implicated in the oxidative-stress responses were found to play a significant role in mutation suppression. Furthermore, TSA1 , which encodes thioredoxin peroxidase, was found to strongly suppress gross chromosomal rearrangements. These results provide a global view of the nonessential genes involved in preventing mutagenesis. Study of such genes should provide useful clues in identification of human genes potentially involved in cancer predisposition and in understanding their mechanisms of action.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A comprehensive analysis of protein–protein interactions in Saccharomyces cerevisiae
Uetz, P., Giot, L., Cagney, G., Mansfield, T. A., Judson, R. S., Knight, J. R., Lockshon, D., Narayan, V., Srinivasan, M., Pochart, P., et al. (2000) · Nature · doi:10.1038/35001009 · Cited by 4,706
Functional profiling of the Saccharomyces cerevisiae genome
Giaever, G., Chu, A. M., Ni, L., Connelly, C., Riles, L., Véronneau, S., Dow, S., Lucau-Danila, A., Anderson, K., André, B., et al. (2002) · Nature · doi:10.1038/nature00935 · Cited by 4,316
Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
Ho, Y., Gruhler, A., Heilbut, A., Bader, G. D., Moore, L., Adams, S.-L., Millar, A., Taylor, P., Bennett, K., Boutilier, K., et al. (2002) · Nature · doi:10.1038/415180a · Cited by 3,601
A comprehensive two-hybrid analysis to explore the yeast protein interactome
Ito, T., Chiba, T., Ozawa, R., Yoshida, M., Hattori, M., & Sakaki, Y. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.061034498 · Cited by 3,566
Wang, J. C. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.003223 · Cited by 1,832
The distribution of the numbers of mutants in bacterial populations
Lea, D. E., & Coulson, C. A. (1949) · Journal of Genetics · doi:10.1007/bf02986080 · Cited by 1,450
Free radical-induced damage to DNA: mechanisms and measurement
Dizdaroglu, M., Jaruga, P., Birincioglu, M., & Rodriguez, H. (2002) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(02)00826-2 · Cited by 953
Eukaryotic DNA mismatch repair
Kolodner, R. D., & Marsischky, G. T. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80013-6 · Cited by 870
Self-citationThe Copper Chaperone for Superoxide Dismutase
Culotta, V. C., Klomp, L. W. J., Strain, J., Casareno, R. L. B., Krems, B., & Gitlin, J. D. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.38.23469 · Cited by 850
Oxidative stress responses of the yeastSaccharomyces cerevisiae
Jamieson, D. J. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199812)14:16<1511::aid-yea356>3.0.co;2-s · Cited by 805
Cited by
Trends in oxidative aging theories
Muller, F. L., Lustgarten, M. S., Jang, Y., Richardson, A., & Van Remmen, H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.03.034 · Cited by 1,053
Repair and Genetic Consequences of Endogenous DNA Base Damage in Mammalian Cells
Barnes, D. E., & Lindahl, T. (2004) · Annual Review of Genetics · doi:10.1146/annurev.genet.38.072902.092448 · Cited by 753
A DNA Integrity Network in the Yeast Saccharomyces cerevisiae
Pan, X., Ye, P., Yuan, D. S., Wang, X., Bader, J. S., & Boeke, J. D. (2006) · Cell · doi:10.1016/j.cell.2005.12.036 · Cited by 537
Gresham, D., Desai, M. M., Tucker, C. M., Jenq, H. T., Pai, D. A., Ward, A., DeSevo, C. G., Botstein, D., & Dunham, M. J. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000303 · Cited by 482
Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae
Fabrizio, P., Battistella, L., Vardavas, R., Gattazzo, C., Liou, L.-L., Diaspro, A., Dossen, J. W., Gralla, E. B., & Longo, V. D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200404002 · Cited by 355
Metadata
- Authors
- Huang, M.-E., Rio, A.-G., Nicolas, A., & Kolodner, R. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-09-12
- Volume
- 100
- Issue
- 20
- Pages
- 11529-11534
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2135257384
- Cited by
- 264
- References
- 54
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. https://app.cochat.ai/papers/10.1073/pnas.2035018100
- The paper
- Huang, M.-E., Rio, A.-G., Nicolas, A., & Kolodner, R. D. (2003). A genomewide screen in Saccharomyces cerevisiae for genes that suppress the accumulation of mutations. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2035018100
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
