The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The role of reactive oxygen species on Plasmodium melanotic encapsulation in Anopheles gambiae
Open accessAbstract
Malaria transmission depends on the competence of some Anopheles mosquitoes to sustain Plasmodium development (susceptibility). A genetically selected refractory strain of Anopheles gambiae blocks Plasmodium development, melanizing, and encapsulating the parasite in a reaction that begins with tyrosine oxidation, and involves three quantitative trait loci. Morphological and microarray mRNA expression analysis suggest that the refractory and susceptible strains have broad physiological differences, which are related to the production and detoxification of reactive oxygen species. Physiological studies corroborate that the refractory strain is in a chronic state of oxidative stress, which is exacerbated by blood feeding, resulting in increased steady-state levels of reactive oxygen species, which favor melanization of parasites as well as Sephadex beads.
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Cites
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Cited by
The Role of Hemocytes in Anopheles gambiae Antiplasmodial Immunity
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Evolutionary Dynamics of Immune-Related Genes and Pathways in Disease-Vector Mosquitoes
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Wolbachia Invades Anopheles stephensi Populations and Induces Refractoriness to Plasmodium Infection
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Metadata
- Authors
- Kumar, S., Christophides, G. K., Cantera, R., Charles, B., Han, Y. S., Meister, S., Dimopoulos, G., Kafatos, F. C., & Barillas-Mury, C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-11-17
- Volume
- 100
- Issue
- 24
- Pages
- 14139-14144
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2072090415
- Cited by
- 310
- References
- 20
- FWCI
- 6.76
- Type
- journal article
- Language
- en
- Open access
- green
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