Cited by 326Neuropeptides and Animal PhysiologyGastrointestinal motility and disordersCongenital gastrointestinal and neural anomalies

Modulation of specific intestinal epithelial progenitors by enteric neurons

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Bjerknes, Matthew, Cheng, Hazel·2001·Proceedings of the National Academy of Sciences

Abstract

The proglucagon-derived peptide glucagon-like peptide 2 (GLP-2), a product of a subset of gut epithelial cells, is pursued clinically for its ability to stimulate gut epithelial growth and repair. Here we show that although specific epithelial progenitors respond to GLP-2 administration, the epithelium does not express the GLP-2 receptor. Rather, enteric neurons express the receptor, respond to GLP-2, and transmit a signal (which can be blocked by the voltage-gated sodium channel inhibitor tetrodotoxin) back to the epithelium. Thus the nervous system is a key component of a feedback loop regulating epithelial growth and repair.

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Crossref · 10.1073/pnas.211278098

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38 of 38 references verified0 citation errors · 0 not checkable

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  • GLP-2 receptors are present on enteric neurons in guinea pig ileum, mouse jejunum, mouse and pig intestine, and absorptive enterocyte progenitors in mouse jejunum respond to GLP-2 in an enteric neuron-dependent manner.

    “Indeed, GLP-2 receptors are present on enteric neurons in guinea pig ileum, mouse jejunum, mouse and pig intestine (20,51,52) and absorptive enterocyte progenitors in mouse jejunum respond to GLP-2 in an enteric neuron-dependent manner (52).”

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Authors
Bjerknes, M., & Cheng, H.
Affiliations
University of Toronto (CA)
Venue
Proceedings of the National Academy of Sciences
Published
2001-09-25
Volume
98
Issue
22
Pages
12497-12502
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W1987513354
Cited by
325
References
38
Citations by year
2026: 2 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 18 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 13
FWCI
6.75
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Amgen
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords
glucagon-like peptide-2, GLP-2 receptor, enteric neurons, tetrodotoxin, voltage-gated sodium channels, gut-brain signaling
MeSH terms
Glucagon-Like Peptide-1 Receptor, Animals, Glucagon-Like Peptides, Intestinal Mucosa, Neurons, Peptides, Stem Cells, Tetrodotoxin, Genes, fos, Receptors, Glucagon, Mice, Glucagon-Like Peptide 2

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