Modulation of specific intestinal epithelial progenitors by enteric neurons
Open accessAbstract
The proglucagon-derived peptide glucagon-like peptide 2 (GLP-2), a product of a subset of gut epithelial cells, is pursued clinically for its ability to stimulate gut epithelial growth and repair. Here we show that although specific epithelial progenitors respond to GLP-2 administration, the epithelium does not express the GLP-2 receptor. Rather, enteric neurons express the receptor, respond to GLP-2, and transmit a signal (which can be blocked by the voltage-gated sodium channel inhibitor tetrodotoxin) back to the epithelium. Thus the nervous system is a key component of a feedback loop regulating epithelial growth and repair.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GLP-2 receptors are present on enteric neurons in guinea pig ileum, mouse jejunum, mouse and pig intestine, and absorptive enterocyte progenitors in mouse jejunum respond to GLP-2 in an enteric neuron-dependent manner.
“Indeed, GLP-2 receptors are present on enteric neurons in guinea pig ileum, mouse jejunum, mouse and pig intestine (20,51,52) and absorptive enterocyte progenitors in mouse jejunum respond to GLP-2 in an enteric neuron-dependent manner (52).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [52]
Cites
Induction of c-fos-like protein in spinal cord neurons following sensory stimulation
Hunt, S. P., Pini, A., & Evan, G. I. (1987) · Nature · doi:10.1038/328632a0 · Cited by 1,986 · see citing works
Cheng, H., & Leblond, C. P. (1974) · American Journal of Anatomy · doi:10.1002/aja.1001410407 · Cited by 1,737 · see citing works
Self-citationW/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity
Hulzinga, J. D., Thuneberg, L., Klüppel, M., Malysz, J., Mikkelsen, H., & Bernstein, A. (1995) · Nature · doi:10.1038/373347a0 · Cited by 1,432 · see citing works
Lee, J. H., Kim, S.-Y., Kwon, Y. K., Kim, B. J., & So, I. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350075 · Cited by 1,380 · see citing works
Baynash, A. G., Hosoda, K., Giaid, A., Richardson, J., Emoto, N., Hammer, R., & Yanagisawa, M. (1994) · Cell · doi:10.1016/0092-8674(94)90018-3 · Cited by 974 · see citing works
Kim, B. J., Nam, J., Kim, K. H., Joo, M., Ha, T. S., Weon, K.-Y., Choi, S., Jun, J. Y., Park, E., Wie, J., et al. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000366306 · Cited by 886 · see citing works
Induction of intestinal epithelial proliferation by glucagon-like peptide 2.
Drucker, D. J., Erlich, P., Asa, S. L., & Brubaker, P. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.15.7911 · Cited by 880 · see citing works
Jeppesen, P. B., Hartmann, B., Thulesen, J., Graff, J., Lohmann, J., Hansen, B. S., Tofteng, F., Poulsen, S. S., Madsen, J. L., Holst, J. J., et al. (2001) · Gastroenterology · doi:10.1053/gast.2001.22555 · Cited by 532 · see citing works
Clonal analysis of mouse intestinal epithelial progenitors
Bjerknes, M., & Cheng, H. (1999) · Gastroenterology · doi:10.1016/s0016-5085(99)70222-2 · Cited by 429 · see citing works
Self-citationFarrell, C. L., Bready, J. V., Rex, K. L., Chen, J. N., DiPalma, C., Whitcomb, K. L., Yin, S., Hill, D. C., Wiemann, B., Starnes, C. O., et al. (1998) · PubMed · Cited by 357 · see citing works
Enteroendocrine localization of GLP-2 receptor expression in humans and rodents
Yusta, B., Huang, L., Munroe, D. G., Wolff, G., Fantaske, R. P., Sharma, S., Demchyshyn, L. L., Asa, S. L., & Drucker, D. J. (2000) · Gastroenterology · doi:10.1053/gast.2000.16489 · Cited by 339 · see citing works
Prototypic G protein-coupled receptor for the intestinotrophic factor glucagon-like peptide 2
Munroe, D. G., Gupta, A., Kooshesh, F., Vyas, T., Rizkalla, G., Wang, H., Demchyshyn, L. L., Yang, Z., Kamboj, R. K., Chen, H., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.4.1569 · Cited by 328 · see citing works
Regulation of the biological activity of glucagon-like peptide 2 in vivo by dipeptidyl peptidase IV
Drucker, D. J., Shi, Q., Crivici, A., Sumner-Smith, M., Tavares, W., Hill, M. E., DeForest, L., Cooper, S., & Brubaker, P. L. (1997) · Nature Biotechnology · doi:10.1038/nbt0797-673 · Cited by 278 · see citing works
Benjamin, M. A., McKay, D. M., Yang, P.-C., Cameron, H. L., & Perdue, M. H. (2000) · Gut · doi:10.1136/gut.47.1.112 · Cited by 277 · see citing works
Tang‐Christensen, M., Larsen, P. J., Thulesen, J., Rømer, J., & Vrang, N. (2000) · Nature Medicine · doi:10.1038/77535 · Cited by 269 · see citing works
Bjerknes, M., & Cheng, H. (1981) · American Journal of Anatomy · doi:10.1002/aja.1001600105 · Cited by 267 · see citing works
Self-citationHousley, R. M., Morris, C. F., Boyle, W., Ring, B. J., Biltz, R., Tarpley, J. E., Aukerman, S. L., Devine, P. L., Whitehead, R., & Pierce, G. F. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117524 · Cited by 266 · see citing works
GLP-2 augments the adaptive response to massive intestinal resection in rat
Scott, R. B., Kirk, D. R., MacNaughton, W. K., & Meddings, J. B. (1998) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1998.275.5.g911 · Cited by 237 · see citing works
Glucagon-Like Peptide-2 Inhibits Centrally Induced Antral Motility in Pigs
Wøjdemann, M. (1998) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365529850171486 · Cited by 210 · see citing works
Methods for the isolation of intact epithelium from the mouse intestine
Bjerknes, M., & Cheng, H. (1981) · The Anatomical Record · doi:10.1002/ar.1091990412 · Cited by 195 · see citing works
Self-citationWong, W., Poulsom, R., & WRIGHT, N. A. (1999) · Gut · doi:10.1136/gut.44.6.890 · Cited by 184 · see citing works
Deblock, M., & Debrouwer, D. (1993) · Analytical Biochemistry · doi:10.1006/abio.1993.1558 · Cited by 176 · see citing works
Human [Gly2]GLP-2 reduces the severity of colonic injury in a murine model of experimental colitis
Drucker, D. J., Yusta, B., Boushey, R. P., DeForest, L., & Brubaker, P. L. (1999) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1999.276.1.g79 · Cited by 176 · see citing works
Prevention of parenteral nutrition-induced gut hypoplasia by coinfusion of glucagon-like peptide-2
Chance, W. T., Foley‐Nelson, T., Thomas, I., & Balasubramaniam, A. (1997) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1997.273.2.g559 · Cited by 133 · see citing works
Finch, P., Pricolo, V. E., Wu, A., & Finkelstein, S. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8566591 · Cited by 125 · see citing works
Lovshin, J. A., Estall, J. L., Yusta, B., Brown, T. J., & Drucker, D. J. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m009382200 · Cited by 125 · see citing works
Enhancement of Murine Intestinal Stem Cell Survival after Irradiation by Keratinocyte Growth Factor
Khan, W., Shui, C., Ning, S., & Knox, S. J. (1997) · Radiation Research · doi:10.2307/3579609 · Cited by 117 · see citing works
Alavi, K., Schwartz, M. Z., Palazzo, J., & Prasad, R. (2000) · Journal of Pediatric Surgery · doi:10.1053/jpsu.2000.6861 · Cited by 110 · see citing works
Keratinocyte growth factor is highly overexpressed in inflammatory bowel disease.
Brauchle, M. A., Madlener, M., Wagner, A. D., Angermeyer, K., Lauer, U., HOFSCHNEIDER, P. H., Gregor, M., & Werner, S. (1996) · Europe PMC (PubMed Central) · Cited by 109 · see citing works
Sahara, N., Toyoki, A., Ashizawa, Y., Deguchi, T., & Suzuki, K. T. (1996) · The Anatomical Record · doi:10.1002/(sici)1097-0185(199601)244:1 · Cited by 91 · see citing works
Glucagon-Like Peptide 2: A Nutrient-Responsive Gut Growth Factor
Burrin, D. G., Stoll, B., Petersen, Y. M., & Sangild, P. T. (2001) · Journal of Nutrition · doi:10.1093/jn/131.3.709 · Cited by 91 · see citing works
Glucagonoma syndrome demonstrating giant duodenal villi.
Stevens, F. M., Flanagan, R., O’Gorman, D. J., & Buchanan, K. D. (1984) · Gut · doi:10.1136/gut.25.7.784 · Cited by 87 · see citing works
Glucagon-like Peptide 2: A New Treatment for Chemotherapy-Induced Enteritis
Tavakkolizadeh, A., Shen, R., Abraham, P., Kormi, N., Seifert, P. A., Edelman, E. R., Jacobs, D. O., Zinner, M. J., Ashley, S. W., & Whang, E. E. (2000) · Journal of Surgical Research · doi:10.1006/jsre.2000.5917 · Cited by 79 · see citing works
Bajaj‐Elliott, M., Poulsom, R., Pender, S. L. F., Wathen, N. C., & MacDonald, T. T. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2792 · Cited by 78 · see citing works
A new method for the isolation of myenteric plexus from the newborn rat gastrointestinal tract
Schäfer, K., Saffrey, M. J., Burnstock, G., & Mestres-Ventura, P. (1997) · Brain Research Protocols · doi:10.1016/s1385-299x(96)00017-7 · Cited by 75 · see citing works
Chance, W. T., Sheriff, S., Foley‐Nelson, T., Thomas, I., & Balasubramaniam, A. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc372_15 · Cited by 38 · see citing works
Effects of tetrodotoxin on chloride secretion in rabbit distal colon: tissue and cellular studies
Biagi, B. A., Wang, Y. Z., & Cooke, H. J. (1990) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1990.258.2.g223 · Cited by 27 · see citing works
Chemical modulation of sodium channels
Narahashi, T. (1998) · doi:10.1093/oso/9780198523604.003.0002 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Pull, S. L., Doherty, J. M., Mills, J. C., Gordon, J. I., & Stappenbeck, T. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0405979102 · Cited by 605 · see citing works
Mitogenic Influence of Human R-Spondin1 on the Intestinal Epithelium
Kim, K., Kakitani, M., Zhao, J., Oshima, T., Tang, T., Binnerts, M. E., Liu, Y., Boyle, B., Park, E., Emtage, P. C. R., et al. (2005) · Science · doi:10.1126/science.1112521 · Cited by 587 · see citing works
Malnutrition as an enteric infectious disease with long-term effects on child development
Guerrant, R. L., Oriá, R. B., Moore, S. R., Oriá, M. O. B., & Lima, A. Â. M. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2008.00082.x · Cited by 544 · see citing works
Brubaker, P. L., & Drucker, D. J. (2004) · Endocrinology · doi:10.1210/en.2004-0015 · Cited by 539 · see citing works
International Union of Pharmacology. XXXV. The Glucagon Receptor Family
Mayo, K. E., Miller, L. J., BATAILLE, D., Dalle, S., Göke, B., Thorens, B., & Drucker, D. J. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.1.6 · Cited by 507 · see citing works
Biological actions and therapeutic potential of the glucagon-like peptides
Drucker, D. J. (2002) · Gastroenterology · doi:10.1053/gast.2002.31068 · Cited by 500 · see citing works
Glucagon-Like Peptides: Regulators of Cell Proliferation, Differentiation, and Apoptosis
Drucker, D. J. (2003) · Molecular Endocrinology · doi:10.1210/me.2002-0306 · Cited by 484 · see citing works
Sharkey, K. A., & Mawe, G. M. (2022) · Physiological Reviews · doi:10.1152/physrev.00018.2022 · Cited by 423 · see citing works
Physiology and Pharmacology of the Enteroendocrine Hormone Glucagon-Like Peptide-2
Drucker, D. J., & Yusta, B. (2013) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170317 · Cited by 344 · see citing works
Brittan, M., & Wright, N. A. (2002) · The Journal of Pathology · doi:10.1002/path.1155 · Cited by 330 · see citing works
Epithelial restitution and wound healing in inflammatory bowel disease
Sturm, A., & Dignass, A. U. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.348 · Cited by 334 · see citing works
Role of Gastrointestinal Hormones in Postprandial Reduction of Bone Resorption
Henriksen, D. B., Alexandersen, P., Bjarnason, N. H., Vilsbøll, T., Hartmann, B., Henriksen, E. E., Byrjalsen, I., Krarup, T., Holst, J. J., & Christiansen, C. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.12.2180 · Cited by 331 · see citing works
Hirschsprung disease — integrating basic science and clinical medicine to improve outcomes
Heuckeroth, R. O. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2017.149 · Cited by 305 · see citing works
Sneddon, J. B., Zhen, H. H., Montgomery, K. D., van de Rijn, M., Tward, A. D., West, R. B., Gladstone, H. B., Chang, H. Y., Morganroth, G. S., Oro, A. E., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606857103 · Cited by 299 · see citing works
Glucose transporters in the small intestine in health and disease
Koepsell, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02439-5 · Cited by 290 · see citing works
The Intestinal Stem Cell Niche: Homeostasis and Adaptations
Santos, A. J. M., Lo, Y., Mah, A. T., & Kuo, C. J. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.08.001 · Cited by 277 · see citing works
The digestive neuronal–glial–epithelial unit: a new actor in gut health and disease
Neunlist, M., Landeghem, L. V., Mahé, M. M., Derkinderen, P., Varannes, S. B. D., & Rolli‐Derkinderen, M. (2012) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2012.221 · Cited by 277 · see citing works
Alison, M. R., Poulsom, R., Forbes, S. J., & Wright, N. A. (2002) · The Journal of Pathology · doi:10.1002/path.1187 · Cited by 275 · see citing works
Guan, X., Karpen, H. E., Stephens, J. E., Bukowski, J. T., Niu, S., Zhang, G., Stoll, B., Finegold, M. J., Holst, J. J., Hadsell, D. L., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2005.11.005 · Cited by 258 · see citing works
Unexpected Roles for the Second Brain: Enteric Nervous System as Master Regulator of Bowel Function
Schneider, S., Wright, C. M., & Heuckeroth, R. O. (2018) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021317-121515 · Cited by 239 · see citing works
Oral and intestinal mucositis — causes and possible treatments
Duncan, M., & Grant, G. (2003) · Alimentary Pharmacology & Therapeutics · doi:10.1046/j.1365-2036.2003.01784.x · Cited by 232 · see citing works
Ørskov, C., Hartmann, B., Poulsen, S. S., Thulesen, J., Hare, K. J., & Holst, J. J. (2004) · Regulatory Peptides · doi:10.1016/j.regpep.2004.07.009 · Cited by 214 · see citing works
Mechanisms of intestinal adaptation
Rubin, D. C., & Levin, M. S. (2016) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2016.03.007 · Cited by 209 · see citing works
Functional circuits and signal processing in the enteric nervous system
Fung, C., & Berghe, P. V. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03543-6 · Cited by 205 · see citing works
Dubé, P. E., Forse, C. L., Bahrami, J., & Brubaker, P. L. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.05.055 · Cited by 200 · see citing works
Enteric neural pathways mediate the anti-inflammatory actions of glucagon-like peptide 2
Sigalet, D. L., Wallace, L. E., Holst, J. J., Martin, G. R., Kaji, T., Tanaka, H., & Sharkey, K. A. (2007) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00530.2006 · Cited by 197 · see citing works
Cardiac Function in Mice Lacking the Glucagon-Like Peptide-1 Receptor
Gros, R., You, X., Baggio, L. L., Kabir, M. G., Sadi, A. M., Mungrue, I. N., Parker, T. G., Huang, Q., Drucker, D. J., & Husain, M. (2003) · Endocrinology · doi:10.1210/en.2003-0007 · Cited by 192 · see citing works
Guan, X., Stoll, B., Lu, X., Tappenden, K. A., Holst, J. J., Hartmann, B., & Burrin, D. G. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00667-x · Cited by 192 · see citing works
Loeffler, M., & Roeder, I. (2002) · Cells Tissues Organs · doi:10.1159/000057688 · Cited by 186 · see citing works
Requirement of Notch activation during regeneration of the intestinal epithelia
Okamoto, R., Tsuchiya, K., Nemoto, Y., Akiyama, J., Nakamura, T., Kanai∥, T., & Watanabe, M. (2008) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.90225.2008 · Cited by 182 · see citing works
Intestinal Stem Cell Niche: The Extracellular Matrix and Cellular Components
Meran, L., Baulies, A., & Li, V. S. W. (2017) · Stem Cells International · doi:10.1155/2017/7970385 · Cited by 178 · see citing works
Frontiers in glucagon-like peptide-2: multiple actions, multiple mediators
Dubé, P. E., & Brubaker, P. L. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00149.2007 · Cited by 166 · see citing works
Four-month treatment with GLP-2 significantly increases hip BMD
Henriksen, D. B., Alexandersen, P., Hartmann, B., Adrian, C. L., Byrjalsen, I., Bone, H. G., Holst, J. J., & Christiansen, C. (2009) · Bone · doi:10.1016/j.bone.2009.07.008 · Cited by 164 · see citing works
Molecular Properties of Adult Mouse Gastric and Intestinal Epithelial Progenitors in Their Niches
Giannakis, M., Stappenbeck, T. S., Mills, J. C., Leip, D., Lovett, M., Clifton, S. W., Ippolito, J. E., Glasscock, J. I., Arumugam, M., Brent, M. R., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512118200 · Cited by 164 · see citing works
Otto, W. R. (2002) · The Journal of Pathology · doi:10.1002/path.1160 · Cited by 159 · see citing works
The Enteric Nervous System and Its Emerging Role as a Therapeutic Target
Fleming, M., Ehsan, L., Moore, S., & Levin, D. (2020) · Gastroenterology Research and Practice · doi:10.1155/2020/8024171 · Cited by 130 · see citing works
Burrin, D. G., Stoll, B., Guan, X., Cui, L., Chang, X., & Holst, J. J. (2004) · Endocrinology · doi:10.1210/en.2004-1119 · Cited by 150 · see citing works
Estall, J. L., & Drucker, D. J. (2006) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.26.061505.111223 · Cited by 147 · see citing works
Martin, G. R., Wallace, L. E., & Sigalet, D. L. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00509.2003 · Cited by 147 · see citing works
Buchman, A. L., Katz, S., Fang, J. C., Bernstein, C. N., & Abou‐Assi, S. G. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21117 · Cited by 144 · see citing works
The “cryptic” mechanism of action of glucagon-like peptide-2
Rowland, K., & Brubaker, P. L. (2011) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00039.2011 · Cited by 143 · see citing works
Glucose sensing and signalling; regulation of intestinal glucose transport
Shirazi-Beechey, S. P., Moran, A. W., Batchelor, D. J., Daly, K., & Al-Rammahi, M. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111000103 · Cited by 139 · see citing works
Nutrient-stimulated GLP-2 release and crypt cell proliferation in experimental short bowel syndrome
Martin, G. R., Wallace, L. E., Hartmann, B., Holst, J. J., Demchyshyn, L. L., Toney, K., & Sigalet, D. L. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00242.2004 · Cited by 136 · see citing works
Intestinal Fructose and Glucose Metabolism in Health and Disease
Merino, B., Fernández-Díaz, C. M., Cózar‐Castellano, I., & Perdomo, G. (2019) · Nutrients · doi:10.3390/nu12010094 · Cited by 136 · see citing works
Glucagon-like peptide-2 increases mesenteric blood flow in humans
Bremholm, L., Hornum, M., Henriksen, B. M., Larsen, S., & Holst, J. J. (2008) · Scandinavian Journal of Gastroenterology · doi:10.1080/00365520802538195 · Cited by 134 · see citing works
Shin, E. D., Estall, J. L., Izzo, A. A., Drucker, D. J., & Brubaker, P. L. (2005) · Gastroenterology · doi:10.1053/j.gastro.2005.02.033 · Cited by 133 · see citing works
Stress impairs murine intestinal barrier function: improvement by glucagon-like peptide-2
Cameron, H. L., & Perdue, M. H. (2005) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.085373 · Cited by 128 · see citing works
Glucagon-like peptide 2 (GLP-2) accelerates the growth of colonic neoplasms in mice
Thulesen, J., Hartmann, B., Hare, K. J., Kissow, H., Ørskov, C., Holst, J. J., & Poulsen, S. S. (2004) · Gut · doi:10.1136/gut.2003.035212 · Cited by 124 · see citing works
Glucagon-like peptide 2 function in domestic animals
Burrin, D. G., Stoll, B., & Guan, X. (2003) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(02)00210-2 · Cited by 121 · see citing works
Gut adaptation and the glucagon-like peptides
Drucker, D. J. (2002) · Gut · doi:10.1136/gut.50.3.428 · Cited by 121 · see citing works
Disassociation of bone resorption and formation by GLP-2
Henriksen, D. B., Alexandersen, P., Hartmann, B., Adrian, C. L., Byrjalsen, I., Bone, H. G., Holst, J. J., & Christiansen, C. (2006) · Bone · doi:10.1016/j.bone.2006.09.025 · Cited by 121 · see citing works
Intestinal Stem Cells and Their Defining Niche
Tan, D. W., & Barker, N. (2014) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/b978-0-12-416022-4.00003-2 · Cited by 116 · see citing works
The regulatory niche of intestinal stem cells
Sailaja, B. S., He, X., & Li, L. (2016) · The Journal of Physiology · doi:10.1113/jp271931 · Cited by 115 · see citing works
Jeppesen, P. B. (2012) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x11436318 · Cited by 117 · see citing works
ErbB Signaling Is Required for the Proliferative Actions of GLP-2 in the Murine Gut
Yusta, B., Holland, D. P., Koehler, J. A., Maziarz, M., Estall, J. L., Higgins, R. R., & Drucker, D. J. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.05.057 · Cited by 115 · see citing works
Intestinal Epithelial Stem Cells and Progenitors
Bjerknes, M., & Cheng, H. (2006) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(06)19014-x · Cited by 112 · see citing works
Self-citationMuscarinic receptor subtypes in the alimentary tract.
Tobin, G., Giglio, D., & Lundgren, O. (2009) · PubMed · Cited by 112 · see citing works
Brubaker, P. L. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1317.006 · Cited by 111 · see citing works
Localization and Activation of Glucagon-Like Peptide-2 Receptors on Vagal Afferents in the Rat
Nelson, D. W., Sharp, J. W., Brownfield, M. S., Raybould, H. E., & Ney, D. M. (2007) · Endocrinology · doi:10.1210/en.2006-1232 · Cited by 111 · see citing works
Krishnan, K., Arnone, B., & Buchman, A. L. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21316 · Cited by 110 · see citing works
Bremholm, L., Hornum, M., Andersen, U. B., Hartmann, B., Holst, J. J., & Jeppesen, P. B. (2011) · Regulatory Peptides · doi:10.1016/j.regpep.2011.03.003 · Cited by 109 · see citing works
Fu, Y., Egorova, A., Sobieski, C., Kuttiyara, J., Calafiore, M., Takashima, S., Clevers, H. C., & Hanash, A. M. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.003 · Cited by 102 · see citing works
Review article: a comparison of glucagon‐like peptides 1 and 2
Janssen, P., Rotondò, A., Mulè, F., & Tack, J. F. (2012) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.12092 · Cited by 105 · see citing works
Glucagon‐like Peptide‐2 and the Regulation of Intestinal Growth and Function
Brubaker, P. L. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170055 · Cited by 104 · see citing works
Apelin targets gut contraction to control glucose metabolism via the brain
Fournel, A., Drougard, A., Duparc, T., Marlin, A., Brierley, S. M., Castro, J., Gonidec, S. L., Masri, B., Colom, A., Lucas, A., et al. (2015) · Gut · doi:10.1136/gutjnl-2015-310230 · Cited by 101 · see citing works
The intestinal stem cell niche: There grows the neighborhood
Mills, J. C., & Gordon, J. I. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231487198 · Cited by 100 · see citing works
Role of luminal nutrients and endogenous GLP-2 in intestinal adaptation to mid-small bowel resection
Dahly, E. M., Gillingham, M. B., Guo, Z., Murali, S. G., Nelson, D. W., Holst, J. J., & Ney, D. M. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00293.2002 · Cited by 96 · see citing works
Yusta, B., Estall, J. L., & Drucker, D. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m201358200 · Cited by 91 · see citing works
Small intestinal stem cell markers
Montgomery, R. K., & Breault, D. T. (2008) · Journal of Anatomy · doi:10.1111/j.1469-7580.2008.00925.x · Cited by 91 · see citing works
Teduglutide ([Gly2]GLP‐2) protects small intestinal stem cells from radiation damage
Booth, C. E., Booth, D., Williamson, S., Demchyshyn, L. L., & Potten, C. S. (2004) · Cell Proliferation · doi:10.1111/j.1365-2184.2004.00320.x · Cited by 89 · see citing works
Glucagon and Glucagon-Like Peptide Receptors as Drug Targets
Estall, J. L., & Drucker, D. J. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206776873671 · Cited by 88 · see citing works
Proglucagon-Derived Peptides: Mechanisms of Action and Therapeutic Potential
Sinclair, E. M., & Drucker, D. J. (2005) · Physiology · doi:10.1152/physiol.00030.2005 · Cited by 87 · see citing works
Rowland, K., Trivedi, S., Lee, D., Wan, K., Kulkarni, R., Holzenberger, M., & Brubaker, P. L. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.09.014 · Cited by 86 · see citing works
Using biomaterials to study stem cell mechanotransduction, growth and differentiation
McMurray, R. J., Dalby, M. J., & Tsimbouri, P. M. (2014) · Journal of Tissue Engineering and Regenerative Medicine · doi:10.1002/term.1957 · Cited by 85 · see citing works
Dubé, P. E., Rowland, K., & Brubaker, P. L. (2007) · Endocrinology · doi:10.1210/en.2007-0561 · Cited by 85 · see citing works
Role of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing
Shirazi‐Beechey, S. P., Daly, K., Al-Rammahi, M. A., Moran, A. W., & Bravo, D. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002286 · Cited by 85 · see citing works
Glucagon-Like Peptide-2 and Common Therapeutics in a Murine Model of Ulcerative Colitis
L’Heureux, M.-C., & Brubaker, P. L. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.103.051771 · Cited by 84 · see citing works
Intestinal adaptation after massive intestinal resection
Weale, A. R., Edwards, A. G., Bailey, M., & Lear, P. A. (2005) · Postgraduate Medical Journal · doi:10.1136/pgmj.2004.023846 · Cited by 81 · see citing works
Pancreatic cell lineage analyses in mice
Herrera, P., Népote, V., & Delacour, A. (2002) · Endocrine · doi:10.1385/endo:19:3:267 · Cited by 68 · see citing works
Growth factors: possible roles for clinical management of the short bowel syndrome
McMellen, M. E., Wakeman, D. S., Longshore, S. W., McDuffie, L. A., & Warner, B. W. (2009) · Seminars in Pediatric Surgery · doi:10.1053/j.sempedsurg.2009.11.010 · Cited by 79 · see citing works
Epithelial Stem Cells and Their Niche: There's No Place Like Home
Rizvi, A. Z., & Wong, M. H. (2005) · Stem Cells · doi:10.1634/stemcells.2004-0096 · Cited by 79 · see citing works
Martin, G. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i26.4117 · Cited by 78 · see citing works
Barbara, P. D. S., Williams, J., Goldstein, A. M., Doyle, A. M., Nielsen, C. M., Winfield, S., Faure, S., & Roberts, D. J. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20554 · Cited by 77 · see citing works
Plasticity of Paneth cells and their ability to regulate intestinal stem cells
Mei, X., Gu, M., & Li, M. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01857-7 · Cited by 76 · see citing works
Cellular and Molecular Mechanisms of the Epithelial Repair in IBD
Okamoto, R., & Watanabe, M. (2005) · Digestive Diseases and Sciences · doi:10.1007/s10620-005-2804-5 · Cited by 75 · see citing works
Glucagon-like peptide-2-enhanced barrier function reduces pathophysiology in a model of food allergy
Cameron, H. L., Yang, P., & Perdue, M. H. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00231.2002 · Cited by 74 · see citing works
El‐Jamal, N., Erdual, E., Neunlist, M., Koriche, D., Dubuquoy, C., Maggiotto, F., Chevalier, J., Berrebi, D. D., Dubuquoy, L., Boulanger, É., et al. (2014) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00389.2012 · Cited by 73 · see citing works
Glucagon-like peptide-1 and glucagon-like peptide-2
Baggio, L. L., & Drucker, D. J. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.08.001 · Cited by 73 · see citing works
Glucagon-Like Peptide-2 Receptor Activation in the Rat Intestinal Mucosa
Walsh, N. A., Yusta, B., DaCambra, M. P., Anini, Y., Drucker, D. J., & Brubaker, P. L. (2003) · Endocrinology · doi:10.1210/en.2003-0309 · Cited by 73 · see citing works
Stephens, J. E., Stoll, B., Cottrell, J. J., Chang, X., Helmrath, M. A., & Burrin, D. G. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00588.2005 · Cited by 72 · see citing works
The Pathogenesis of Resection-Associated Intestinal Adaptation
Warner, B. W. (2016) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.05.001 · Cited by 72 · see citing works
Daly, K., Al-Rammahi, M., Arora, D. K., Moran, A. W., Proudman, C. J., Ninomiya, Y., & Shirazi-Beechey, S. P. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00031.2012 · Cited by 70 · see citing works
Leen, J., Izzo, A. A., Upadhyay, C., Rowland, K., Dubé, P. E., Gu, S., Heximer, S. P., Rhodes, C. J., Storm, D. R., Lund, P. K., et al. (2010) · Endocrinology · doi:10.1210/en.2010-0822 · Cited by 70 · see citing works
Iakoubov, R., Lauffer, L. M., Trivedi, S., Kim, Y.-I. J., & Brubaker, P. L. (2009) · Endocrinology · doi:10.1210/en.2009-0295 · Cited by 70 · see citing works
Wideman, R. D., Covey, S. D., Webb, G. C., Drucker, D. J., & Kieffer, T. J. (2007) · Diabetes · doi:10.2337/db07-0563 · Cited by 70 · see citing works
Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine
Ramsanahie, A. P., Duxbury, M. S., Grikscheit, T. C., Perez, A., Rhoads, D. B., Gardner-Thorpe, J., Ogilvie, J. B., Ashley, S. W., Vacanti, J. P., & Whang, E. E. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00374.2002 · Cited by 70 · see citing works
Petersen, Y. M., Bjørnvad, C. R., Sangild, P. T., Hartmann, B., Holst, J. J., & Huërou‐Luron, I. L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.6.1781 · Cited by 70 · see citing works
Toumi, F., Neunlist, M., Cassagnau, E., Parois, S., LABOISSE, C. L., Galmiche, J. ‐., & Jarry, A. (2003) · Neurogastroenterology & Motility · doi:10.1046/j.1365-2982.2003.00409.x · Cited by 68 · see citing works
Intestinal Epithelial Stem/Progenitor Cells Are Controlled by Mucosal Afferent Nerves
Lundgren, O., Jodal, M., Jansson, M., Ryberg, A. T., & Svensson, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016295 · Cited by 67 · see citing works
Glucagon-like Peptide-2 Induces a Specific Pattern of Adaptation in Remnant Jejunum
Sigalet, D. L., Bawazir, O. A., Martin, G. R., Wallace, L. E., Zaharko, G., Miller, A., & Zubaidi, A. M. (2006) · Digestive Diseases and Sciences · doi:10.1007/s10620-006-9077-5 · Cited by 67 · see citing works
- Authors
- Bjerknes, M., & Cheng, H.
- Affiliations
- University of Toronto (CA)
- ORCID
- Bjerknes, Matthew
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-09-25
- Volume
- 98
- Issue
- 22
- Pages
- 12497-12502
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC60082
- OpenAlex
- W1987513354
- Cited by
- 325
- References
- 38
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 7 · 2020: 18 · 2019: 10 · 2018: 14 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 13 · 2013: 10 · 2012: 13
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amgen
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
- Keywords
- glucagon-like peptide-2, GLP-2 receptor, enteric neurons, tetrodotoxin, voltage-gated sodium channels, gut-brain signaling
- MeSH terms
- Glucagon-Like Peptide-1 Receptor, Animals, Glucagon-Like Peptides, Intestinal Mucosa, Neurons, Peptides, Stem Cells, Tetrodotoxin, Genes, fos, Receptors, Glucagon, Mice, Glucagon-Like Peptide 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review