Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transport
Abstract
The heteromeric sweet taste receptor T1R2-T1R3 is expressed on the luminal membrane of certain populations of enteroendocrine cells. Sensing of sugars and other sweet compounds by this receptor activates a pathway in enteroendocrine cells, resulting in secretion of a number of gut hormones, including glucagon-like peptide 2 (GLP-2). This subsequently leads to upregulation in the expression of intestinal Na+/glucose cotransporter, SGLT1, and increased intestinal glucose absorption. On the basis of the current information available on the horse genome sequence, it has been proposed that the gene for T1R2 ( Tas1R2) is absent in the horse. We show here, however, that horses express both the mRNA and protein for T1R2. Equine T1R2 is most closely homologous to that in the pig and the cow. T1R2 protein, along with T1R3, α-gustducin, and GLP-2 proteins are coexpressed in equine intestinal endocrine cells. Intravenous administration of GLP-2, in rats and pigs, leads to an increase in the expression of SGLT1 in absorptive enterocytes and enhancement in blood glucose concentrations. GLP-2 receptor is expressed in enteric neurons, excluding the direct effect of GLP-2 on enterocytes. However, electric stimulation of enteric neurons generates a neural response leading to SGLT1 upregulation, suggesting that sugar in the intestine activates a reflex increase in the functional expression of SGLT1. Horses possess the ability to upregulate SGLT1 expression in response to increased dietary carbohydrates, and to enhance the capacity of the gut to absorb glucose. The gut sweet receptor provides an accessible target for manipulating the equine gut to absorb glucose (and water), allowing greater energy uptake and hydration for hard-working horses.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
GLP-2 release is STR-dependent in rodents and inhibited by gurmarin.
“This is also true for GLP-2 release, which is STR-dependent in rodents (28,29) and inhibited by the murine STR inhibitor, gurmarin (30).”
From Gut mechanisms linking intestinal sweet sensing to glycemic control (2018) · cites this paper as [30]
Cites
The neighbor-joining method: a new method for reconstructing phylogenetic trees.
Saitou, N., & Nei, M. (1987) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a040454 · Cited by 59,962 · see citing works
PHYLIP-Phylogeny inference package (Version 3.2)
Felsenstein, J. (1989) · Cladistics · Cited by 17,848 · see citing works
The rapid generation of mutation data matrices from protein sequences
Jones, D. T., Taylor, W. R., & Thornton, J. M. (1992) · Computer applications in the biosciences · doi:10.1093/bioinformatics/8.3.275 · Cited by 6,916 · see citing works
A Greedy Algorithm for Aligning DNA Sequences
Zhang, Z., Schwartz, S., Wagner, L., & Miller, W. (2000) · Journal of Computational Biology · doi:10.1089/10665270050081478 · Cited by 5,459 · see citing works
Mammalian sweet taste receptors
Nelson, G., Hoon, M. A., Chandrashekar, J., Zhang, Y., Ryba, N. J. P., & Zuker, C. S. (2001) · Cell · doi:10.1016/s0092-8674(01)00451-2 · Cited by 1,702 · see citing works
Human receptors for sweet and umami taste
Li, X., Staszewski, L. M., Xu, H., Durick, K., Zoller, M. J., & Adler, E. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.072090199 · Cited by 1,380 · see citing works
Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1.
Jang, H.-J., Kokrashvili, Z., Theodorakis, M. J., Carlson, O. D., Kim, B.-J., Zhou, J., Kim, H. H., Xu, X., Chan, S. L., Juhaszova, M., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706890104 · Cited by 995 · cited 1× · see citing works
“Further experimental evidence suggests that luminal sugars, via the sweet receptor expressed in enteroendocrine cells, stimulate secretion of gut hormones, such as glucose-dependent insulinotropic peptide (GIP), glucagon-like peptide 1 (GLP-1), and GLP-2 (23, 30).”
BackgroundMargolskee, R. F., Dyer, J., Kokrashvili, Z., Salmon, K. S. H., Ilegems, E., Daly, K., Maillet, E. L., Ninomiya, Y., Mosinger, B., & Shirazi-Beechey, S. P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706678104 · Cited by 882 · see citing works
Self-citationDyer, J., Salmon, K. S. H., Zibrik, L., & Shirazi‐Beechey, S. P. (2005) · Biochemical Society Transactions · doi:10.1042/bst0330302 · Cited by 383 · see citing works
Self-citationModulation of specific intestinal epithelial progenitors by enteric neurons
Bjerknes, M., & Cheng, H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.211278098 · Cited by 325 · see citing works
Comparative Genomics of Natural Killer Cell Receptor Gene Clusters
Kelley, J., Walter, L., & Trowsdale, J. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010027 · Cited by 290 · see citing works
Specific Regulation of Intestinal Nutrient Transporters by their Dietary Substrates
Ferraris, R. P., & Diamond, J. M. (1989) · Annual Review of Physiology · doi:10.1146/annurev.ph.51.030189.001013 · Cited by 276 · see citing works
Upregulation of SGLT-1 transport activity in rat jejunum induced by GLP-2 infusion in vivo
Cheeseman, C. I. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.6.r1965 · Cited by 267 · see citing works
Pseudogenization of a Sweet-Receptor Gene Accounts for Cats' Indifference toward Sugar
Li, X., Li, W., Wang, H., Cao, J., Maehashi, K., Huang, L., Bachmanov, A. A., Reed, D. R., Legrand‐Defretin, V., Beauchamp, G. K., et al. (2005) · PLoS Genetics · doi:10.1371/journal.pgen.0010003 · Cited by 264 · see citing works
Prospective study of equine colic risk factors
Tinker, M. K., White, N. A., Lessard, P., Thatcher, C. D., Pelzer, K. D., DAVIS, B., & Carmel, D. K. (1997) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1997.tb03158.x · Cited by 229 · see citing works
Controls for Immunocytochemistry
Burry, R. W. (2010) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2010.956920 · Cited by 215 · see citing works
Hillyer, M. H., Taylor, F. G. R., PROUDMAN, C. J., Edwards, G. B., Smith, J. E., & French, N. P. (2002) · Equine Veterinary Journal · doi:10.2746/042516402776117746 · Cited by 200 · see citing works
Self-citationDaly, K., PROUDMAN, C. J., Duncan, S. H., Flint, H. J., Dyer, J., & Shirazi‐Beechey, S. P. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511003825 · Cited by 194 · see citing works
Self-citationOntogenic development of lamb intestinal sodium‐glucose co‐transporter is regulated by diet.
Shirazi‐Beechey, S. P., Hirayama, B. A., Wang, Y., Scott, D., Mw, S., & Wright, E. M. (1991) · The Journal of Physiology · doi:10.1113/jphysiol.1991.sp018620 · Cited by 181 · see citing works
Self-citationChromogranin: A newly recognized marker for endocrine cells of the human gastrointestinal tract
Facer, P., Bishop, A. E., Lloyd, R. V., Wilson, B. S., Hennessy, R. J., & Polak, J. M. (1985) · Gastroenterology · doi:10.1016/0016-5085(85)90657-2 · Cited by 165 · see citing works
Glucose sensing and signalling; regulation of intestinal glucose transport
Shirazi-Beechey, S. P., Moran, A. W., Batchelor, D. J., Daly, K., & Al-Rammahi, M. (2011) · Proceedings of the Nutrition Society · doi:10.1017/s0029665111000103 · Cited by 139 · see citing works
Self-citationCirculating and Tissue Forms of the Intestinal Growth Factor, Glucagon-Like Peptide-2
Brubaker, P. L., Crivici, A., Izzo, A. A., Ehrlich, P. F., Tsai, C.-H., & Drucker, D. J. (1997) · Endocrinology · doi:10.1210/endo.138.11.5482 · Cited by 136 · see citing works
Goodson, J. R., Tyznik, W. J., Cline, J. H., & Dehority, B. A. (1988) · Applied and Environmental Microbiology · doi:10.1128/aem.54.8.1946-1950.1988 · Cited by 125 · see citing works
Glucose sensing in the intestinal epithelium
Dyer, J., Vayro, S., King, T. P., & Shirazi‐Beechey, S. P. (2003) · European Journal of Biochemistry · doi:10.1046/j.1432-1033.2003.03721.x · Cited by 117 · see citing works
Self-citationMoran, A. W., Al-Rammahi, M. A., Arora, D. K., Batchelor, D. J., Coulter, E. A., Daly, K., Ionescu, C., Bravo, D., & Shirazi-Beechey, S. P. (2010) · British Journal of Nutrition · doi:10.1017/s0007114510000917 · Cited by 114 · see citing works
Self-citationMoran, A. W., Al-Rammahi, M. A., Arora, D. K., Batchelor, D. J., Coulter, E. A., Ionescu, C., Bravo, D., & Shirazi‐Beechey, S. P. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510000954 · Cited by 109 · see citing works
Self-citationMolecular characterisation of carbohydrate digestion and absorption in equine small intestine
Dyer, J., MEREDIZ, E. F., Salmon, K. S. H., PROUDMAN, C. J., Edwards, G. B., & Shirazi‐Beechey, S. P. (2002) · Equine Veterinary Journal · doi:10.2746/042516402776249209 · Cited by 108 · see citing works
Self-citationStearns, A. T., Balakrishnan, A., Rhoads, D. B., & Tavakkolizadeh, A. (2010) · Annals of Surgery · doi:10.1097/sla.0b013e3181d96e1f · Cited by 106 · see citing works
Progress in Oral Rehydration Therapy
Hirschhorn, N., & Greenough, W. B. (1991) · Scientific American · doi:10.1038/scientificamerican0591-50 · Cited by 100 · see citing works
Evolution of the Sweet Taste Receptor Gene Tas1r2 in Bats
Zhao, H., Zhou, Y., Pinto, C. M., Charles‐Dominique, P., Galindo-González, J. R., Zhang, S. Y., & Zhang, J. (2010) · Molecular Biology and Evolution · doi:10.1093/molbev/msq152 · Cited by 95 · see citing works
Dyer, J., Al-Rammahi, M., Waterfall, L., Salmon, K. S. H., Geor, R. J., Bouré, L., Edwards, G. B., Proudman, C. J., & Shirazi-Beechey, S. P. (2009) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0620-4 · Cited by 88 · see citing works
Self-citationIntestinal glucose sensing and regulation of intestinal glucose absorption
Dyer, J., Daly, K., Salmon, K. S. H., Arora, D. K., Kokrashvili, Z., Margolskee, R. F., & Shirazi‐Beechey, S. P. (2007) · Biochemical Society Transactions · doi:10.1042/bst0351191 · Cited by 85 · see citing works
Self-citationDietary regulation of intestinal brush-border sugar and amino acid transport in carnivores
Buddington, R. K., Chen, J. W., & Diamond, J. M. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.4.r793 · Cited by 84 · see citing works
Response of Horses to Sweet, Salty, Sour and Bitter Solutions
Randall, R. P., Schurg, W. A., & Church, D. C. (1978) · Journal of Animal Science · doi:10.2527/jas1978.47151x · Cited by 77 · see citing works
Molecular Biology of Intestinal Glucose Transport
Shirazi‐Beechey, S. P. (1995) · Nutrition Research Reviews · doi:10.1079/nrr19950005 · Cited by 73 · see citing works
Self-citationEffect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine
Ramsanahie, A. P., Duxbury, M. S., Grikscheit, T. C., Perez, A., Rhoads, D. B., Gardner-Thorpe, J., Ogilvie, J. B., Ashley, S. W., Vacanti, J. P., & Whang, E. E. (2003) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00374.2002 · Cited by 70 · see citing works
Glucagon‐like Peptide 2 Stimulates Intestinal Nutrient Absorption in Parenterally Fed Newborn Pigs
Sangild, P. T., Tappenden, K. A., Malo, C., Petersen, Y. M., Elnif, J., Bartholome, A. L., & Buddington, R. K. (2006) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000228122.82723.1b · Cited by 67 · see citing works
Cottrell, J. J., Stoll, B., Buddington, R. K., Stephens, J. E., Cui, L., Chang, X., & Burrin, D. G. (2005) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00275.2005 · Cited by 62 · see citing works
Batchelor, D. J., Al-Rammahi, M. A., Moran, A. W., Brand, J. G., Li, X., Haskins, M. E., German, A. J., & Shirazi‐Beechey, S. P. (2010) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00262.2010 · Cited by 60 · see citing works
Self-citationEffect of Diet on Glucose Entry and Oxidation Rates in Ponies
Argenzio, R. A., & Hintz, H. F. (1972) · Journal of Nutrition · doi:10.1093/jn/102.7.879 · Cited by 59 · see citing works
Activity of amylase in the gastrointestinal tract of the horse1
Kienzle, E., Radicke, S., Landes, E., Kleffken, D., Illenseer, M., & Meyer, H. (1994) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.1994.tb00392.x · Cited by 57 · see citing works
Baldassano, S., Liu, S., Qu, M.-H., Mulè, F., & Wood, J. D. (2009) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00170.2009 · Cited by 56 · see citing works
Smushkin, G., Sathananthan, A., Man, C. D., Zinsmeister, A. R., Camilleri, M., Cobelli, C., Rizza, R. A., & Vella, A. V. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2561 · Cited by 32 · see citing works
Shigemura, N., Nakao, K., Yasuo, T., Murata, Y., Yasumatsu, K., NAKASHIMA, A., Katsukawa, H., Sako, N., & Ninomiya, Y. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.146 · Cited by 30 · see citing works
Self-citationDebnam, E. S. (2009) · Digestion · doi:10.1159/000199173 · Cited by 26 · see citing works
Carbohydrate digestion and absorption in the equine small intestine.
Mc, R. (1975) · PubMed · Cited by 26 · see citing works
Ventura, J. L., Estruch, A., Rodas, G., & Segura, R. (1994) · European Journal of Applied Physiology · doi:10.1007/bf00571455 · Cited by 25 · see citing works
Amylase Activity in the Small Intestine of the Horse
Roberts, M. C. (1974) · Research in Veterinary Science · doi:10.1016/s0034-5288(18)33665-8 · Cited by 21 · see citing works
Vervuert, I., Coenen, M., & Bichmann, M. (2004) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.2004.00624.x · Cited by 15 · see citing works
Effect of diet on maltase, sucrase and lactase in the small intestinal mucosa of the horse1
Kienzle, E., & Radicke, S. (1993) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/j.1439-0396.1993.tb00311.x · Cited by 13 · see citing works
Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Taste receptors of the gut: emerging roles in health and disease
Depoortere, I. (2014) · Gut · doi:10.1136/gutjnl-2013-305112 · Cited by 315 · see citing works
Bachmanov, A. A., Bosak, N. P., Lin, C., Matsumoto, I., Ohmoto, M., Reed, D. R., & Nelson, T. M. (2014) · Current Pharmaceutical Design · doi:10.2174/13816128113199990566 · Cited by 216 · see citing works
Sensing of amino acids by the gut-expressed taste receptor T1R1-T1R3 stimulates CCK secretion
Daly, K., Al-Rammahi, M. A., Moran, A. W., Marcello, M., Ninomiya, Y., & Shirazi‐Beechey, S. P. (2012) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00074.2012 · Cited by 195 · see citing works
Self-citationThe endocrinology of taste receptors
Calvo, S. S.-C., & Egan, J. M. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.7 · Cited by 142 · see citing works
The avian taste system: Potential implications in poultry nutrition
Roura, E., Baldwin, M. W., & Klasing, K. C. (2012) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2012.11.001 · Cited by 123 · see citing works
Young, R. L., Chia, B., Isaacs, N. J., Ma, J., Khoo, J., Wu, T., Horowitz, M., & Rayner, C. K. (2013) · Diabetes · doi:10.2337/db13-0581 · Cited by 111 · see citing works
Raka, F., Farr, S., Kelly, J., Stoianov, A. M., & Adeli, K. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00036.2019 · Cited by 98 · see citing works
Moran, A. W., Al-Rammahi, M. A., Zhang, C., Bravo, D., Calsamiglia, S., & Shirazi‐Beechey, S. P. (2014) · Journal of Dairy Science · doi:10.3168/jds.2014-8004 · Cited by 94 · see citing works
Self-citationRole of nutrient-sensing taste 1 receptor (T1R) family members in gastrointestinal chemosensing
Shirazi‐Beechey, S. P., Daly, K., Al-Rammahi, M. A., Moran, A. W., & Bravo, D. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114513002286 · Cited by 85 · see citing works
Self-citationFeng, P., Chai, J., Zhou, M., Simon, N., Huang, L., & Wang, H. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.3074-13.2014 · Cited by 55 · see citing works
Cheled-Shoval, S. L., Druyan, S., & Uni, Z. (2015) · Poultry Science · doi:10.3382/ps/pev152 · Cited by 54 · see citing works
The influence of odour, taste and nutrients on feeding behaviour and food preferences in horses
van den Berg, M., Giagos, V., Lee, C., Brown, W. Y., Cawdell-Smith, A. J., & Hinch, G. N. (2016) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2016.08.015 · Cited by 54 · see citing works
Prandi, S., Voigt, A., Meyerhof, W., & Behrens, M. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2621-y · Cited by 53 · see citing works
Influence of glucagon-like peptide 2 on energy homeostasis
Baldassano, S., Amato, A., & Mulè, F. (2016) · Peptides · doi:10.1016/j.peptides.2016.09.010 · Cited by 50 · see citing works
Taste, nutrient sensing and feed intake in pigs (130 years of research: then, now and future)
Roura, E., & Fu, M. (2017) · Animal Feed Science and Technology · doi:10.1016/j.anifeedsci.2017.08.002 · Cited by 50 · see citing works
COMPARATIVE GUT PHYSIOLOGY SYMPOSIUM: Comparative physiology of digestion1
Furness, J. B., Cottrell, J. J., & Bravo, D. M. (2015) · Journal of Animal Science · doi:10.2527/jas.2014-8481 · Cited by 50 · see citing works
Moran, A. W., Al-Rammahi, M. A., Batchelor, D. J., Bravo, D. M., & Shirazi‐Beechey, S. P. (2018) · Frontiers in Nutrition · doi:10.3389/fnut.2018.00101 · Cited by 48 · see citing works
Self-citationNon-Nutritive Sweeteners and Obesity
Fernstrom, J. D. (2014) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-022814-015635 · Cited by 45 · see citing works
Evidence of sugar sensitive genes in the gut of a carnivorous fish species
Polakof, S., & Soengas, J. L. (2013) · Comparative Biochemistry and Physiology Part B Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2013.07.003 · Cited by 44 · see citing works
de Graaf‐Roelfsema, E. (2013) · The Veterinary Journal · doi:10.1016/j.tvjl.2013.09.064 · Cited by 41 · see citing works
Gut mechanisms linking intestinal sweet sensing to glycemic control
Kreuch, D., Keating, D. J., Wu, T., Horowitz, M., Rayner, C. K., & Young, R. L. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00741 · Cited by 40 · see citing works
Effects of age and diet on glucose and insulin dynamics in the horse
Rapson, J., Schott, H. C., Nielsen, B. D., McCutcheon, L. J., Harris, P. A., & Geor, R. J. (2018) · Equine Veterinary Journal · doi:10.1111/evj.12812 · Cited by 40 · see citing works
Risdon, S., Battault, S., Romo-Romo, A., Roustit, M., Briand, L. V., Meyer, G., Almeda‐Valdés, P., & Walther, G. (2021) · Advances in Nutrition · doi:10.1093/advances/nmaa185 · Cited by 39 · see citing works
Connor, E. E., Evock-Clover, C. M., Walker, M. P., Elsasser, T. H., & Kahl, S. (2015) · Journal of Animal Science · doi:10.2527/jas.2014-8577 · Cited by 38 · see citing works
Mace, O. J., & Marshall, F. H. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5906 · Cited by 36 · see citing works
Yuan, X., Liang, X., Cai, W.-J., He, S., Guo, W., & Mai, K. (2020) · BMC Evolutionary Biology · doi:10.1186/s12862-020-1590-1 · Cited by 31 · see citing works
Low calorie sweeteners: Evidence remains lacking for effects on human gut function
Bryant, C. E., & McLaughlin, J. T. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.04.026 · Cited by 30 · see citing works
Biggs, M. E., Kroscher, K. A., Zhao, L., Zhang, Z., Wall, E. H., Bravo, D. M., & Rhoads, R. P. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa131 · Cited by 26 · see citing works
Jankunis, E. S., & Whishaw, I. Q. (2013) · Behavioural Brain Research · doi:10.1016/j.bbr.2013.08.024 · Cited by 23 · see citing works
Kochem, M., Hanselman, E. C., & Breslin, P. A. S. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298239 · Cited by 20 · see citing works
Liou, A. P. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5910 · Cited by 20 · see citing works
Cvijanovic, N., Feinle‐Bisset, C., Young, R. L., & Little, T. J. (2015) · Nutrition Reviews · doi:10.1093/nutrit/nuu026 · Cited by 20 · see citing works
de Laat, M. A., & Fitzgerald, D. M. (2023) · The Veterinary Journal · doi:10.1016/j.tvjl.2023.105967 · Cited by 19 · see citing works
Romo-Romo, A., Aguilar-Salinas, C. A., López-Carrasco, M. G., Guillén-Pineda, L. E., Brito-Córdova, G. X., Gómez-Díaz, R. A., Gomez-Perez, F. J., & Almeda‐Valdés, P. (2020) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2020.03.018 · Cited by 19 · see citing works
Mang, D., Kasubuchi, M., Toyama, T., Yamagishi, T., & Sato, R. (2022) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2022.103858 · Cited by 19 · see citing works
Daly, K., Moran, A. W., Al-Rammahi, M. A., Weatherburn, D., & Shirazi‐Beechey, S. P. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.01.032 · Cited by 17 · see citing works
Self-citationMang, D., Toyama, T., Yamagishi, T., Sun, J., Purba, E. R., Endo, H., Matthews, M. M., Ito, K., Nagata, S., & Sato, R. (2023) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2023.103927 · Cited by 17 · see citing works
Expression of sweet taste receptor and gut hormone secretion in modelled type 2 diabetes
Feng, R., Qian, C., Liu, Q., Jin, Y., Liu, L., Li, S., Liao, Y., Zhou, H., Liu, W., Rayner, C. K., et al. (2017) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2017.08.008 · Cited by 17 · see citing works
DOES EVOLUTIONARY BIOLOGY HELP THE UNDERSTANDING OF METABOLIC SURGERY? A FOCUSED REVIEW
Santoro, S., de Aquino, C. G. G., Filippe Camarotto, M. O. T. A., & Artoni, R. F. (2020) · ABCD Arquivos Brasileiros de Cirurgia Digestiva (São Paulo) · doi:10.1590/0102-672020190001e1503 · Cited by 16 · see citing works
Taste and the Gastrointestinal tract: from physiology to potential therapeutic target for obesity
Sarnelli, G., Annunziata, G., Magno, S., Oriolo, C., Savastano, S., & Colao, A. (2019) · International Journal of Obesity Supplements · doi:10.1038/s41367-019-0012-6 · Cited by 16 · see citing works
Taste Receptor Gene Expression Outside the Gustatory System
Behrens, M., Prandi, S., & Meyerhof, W. (2014) · Topics in medicinal chemistry · doi:10.1007/7355_2014_79 · Cited by 16 · see citing works
Yoshida, R., & Ninomiya, Y. (2023) · Food and health · doi:10.1007/978-3-031-32692-9_2 · Cited by 12 · see citing works
Self-citationCarbohydrate pellets to assess insulin dysregulation in horses
de Laat, M. A., Warnken, T., Delarocque, J., Reiche, D., Grob, A. J., Feige, K., Carslake, H. B., Durham, A. E., Sillence, M. N., Thane, K. E., et al. (2022) · Journal of Veterinary Internal Medicine · doi:10.1111/jvim.16621 · Cited by 12 · see citing works
Mazzoni, M., Bonaldo, A., Gatta, P. P., Vallorani, C., Latorre, R., Canova, M., & Clavenzani, P. (2015) · Fish Physiology and Biochemistry · doi:10.1007/s10695-015-0031-3 · Cited by 12 · see citing works
Mazzoni, M., Bombardi, C., Vallorani, C., Sirri, F., GIORGIO, R. D., Caio, G., Grandis, A., Sternini, C., & Clavenzani, P. (2016) · Poultry Science · doi:10.3382/ps/pew057 · Cited by 10 · see citing works
Tao, R., Li, H., Liu, Y., Tang, S., Han, X., Wang, M., He, Z., Kang, J., Yan, Q., Tan, Z., et al. (2016) · Livestock Science · doi:10.1016/j.livsci.2016.04.010 · Cited by 10 · see citing works
Role of Bitter Taste Receptors in Regulating Gastric Accommodation in Guinea Pigs
Harada, Y., Koseki, J., Sekine, H., Fujitsuka, N., & Kobayashi, H. (2019) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.118.256008 · Cited by 9 · see citing works
Potential Effects of Low-Calorie Sweeteners on Human Health
Chen, H.-P., Kao, Y., Lin, M., Lee, C., Wu, H., & Kuo, H. (2025) · Nutrients · doi:10.3390/nu17172726 · Cited by 7 · see citing works
de Laat, M. A., & Sillence, M. N. (2020) · Animal Production Science · doi:10.1071/an19491 · Cited by 7 · see citing works
Sweet taste receptor inhibitors: Potential treatment for equine insulin dysregulation
de Laat, M. A., Kheder, M. H., Pollitt, C. C., & Sillence, M. N. (2018) · PLoS ONE · doi:10.1371/journal.pone.0200070 · Cited by 7 · see citing works
Sun, D., Liu, L., Mao, S., Zhu, W., & Liu, J. (2019) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13159 · Cited by 7 · see citing works
Mazzoni, M., Karunaratne, T. B., Sirri, F., Petracci, M., GIORGIO, R. D., Sternini, C., & Clavenzani, P. (2018) · Poultry Science · doi:10.3382/ps/pey279 · Cited by 6 · see citing works
Sadaqat, Z., Kaushik, S., & Kain, P. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.96503 · Cited by 6 · see citing works
Loos, C. M. M., & Urschel, K. L. (2025) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2025.106940 · Cited by 4 · see citing works
Impacts of Olfactory Cues on Equine Feeding Behavior
Perry, E. B., Handlos, G. C., & Fenton, J. M. (2024) · Journal of Equine Veterinary Science · doi:10.1016/j.jevs.2024.105096 · Cited by 4 · see citing works
Glucose sensing and homeostasis by adipocyte GPCR
Hasan, N., & Chhabra, K. H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1657747 · Cited by 3 · see citing works
Hanselman, E. C., Harmon, C. P., Deng, D., Sywanycz, S. M., Caronia, L., Jiang, P., & Breslin, P. A. S. (2025) · British Journal of Pharmacology · doi:10.1111/bph.70004 · Cited by 3 · see citing works
Xiong, Y., He, Z., Wu, Q., Xiao, H., Cao, S., Yang, X., Li, Y., Jiang, Z., Zhu, C., & Wang, L. (2025) · Porcine Health Management · doi:10.1186/s40813-024-00414-5 · Cited by 2 · see citing works
Smith, L., Moran, A. W., Al-Rammahi, M. A., Daly, K., & Shirazi‐Beechey, S. P. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1325135 · Cited by 1 · see citing works
Self-citationCiullo, D., & Dotson, C. (2015) · Chemosensory Perception · doi:10.1007/s12078-015-9190-y · Cited by 1 · see citing works
Coenen, M. (2013) · Pferdeheilkunde Equine Medicine · doi:10.21836/pem20130204 · Cited by 1 · see citing works
Kheder, M. H. (2018) · Queensland University of Technology · doi:10.5204/thesis.eprints.122879 · Cited by 1 · see citing works
Studies on glucagon-like peptide-2 (GLP-2) and the equine gastrointestinal tract
Sibthorpe, P. E. M. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.232700 · Cited by 1 · see citing works
Lai, S. W. (2014) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/28080 · Cited by 1 · see citing works
Trindade, K. L. G., de Oliveira, V. T. B. M., Cavalcanti, M. E. D. O., da Silva, M. O., Manso, H. E. C. D. C. C., Filho, J. D. R., Abreu, J. M. G., & Filho, H. C. M. (2017) · Revista Acadêmica Ciência Animal · doi:10.7213/academica.15.2017.04
AL-Bdyry, S. R., & Al-Rammahi, M. A. (2016) · DOAJ (DOAJ: Directory of Open Access Journals)
Self-citationNaftalin, R. J. (2013) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.718020724.793479145
TAS1 receptors. An overview of their functions, expression and genetic variations
", Oprita, G., Babeș, A., & Domocos, D. T. (2022) · Reviews in Biological and Biomedical Sciences · doi:10.31178/rbbs.2021.4.1.4
Behavior and Behavioral Abnormalities in Athletic Horses
McBride, S. D. (2024) · Elsevier eBooks · doi:10.1016/b978-0-7020-8370-9.00049-7
- Authors
- Daly, K., Al-Rammahi, M., Arora, D. K., Moran, A. W., Proudman, C. J., Ninomiya, Y., & Shirazi-Beechey, S. P.
- Affiliations
- University of Liverpool (GB)
- Kyushu University (JP)
- Epithelial Function and Development Group, Department of Functional and Comparative Genomics, Institute of Integrative Biology, Faculty of Health and Life Sciences, University of Liverpool, Liverpool, United Kingdom;
- Venue
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology
- Publisher
- American Physiological Society
- Published
- 2012-07-15
- Volume
- 303
- Issue
- 2
- Pages
- R199-R208
- ISSN
- 0363-6119 (ISSN-L)
- 1522-1490
- OpenAlex
- W2096728081
- Cited by
- 70
- References
- 51
- Citations by year
- 2025: 5 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 7 · 2012: 4
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Regulatory, Integrative and Comparative Physiology (publishedVersion)
- PubMed (publishedVersion)
- Surrey Research Insight Open Access (The University of Surrey) (submittedVersion)
- Funders
- University of Pennsylvania
- Horserace Betting Levy Board
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Biochemical Analysis and Sensing Techniques
- Health Sciences › Veterinary › Equine › Veterinary Equine Medical Research
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Keywords
- sweet taste receptor, T1R2, T1R3, equine small intestine, intestinal glucose absorption, SGLT1, glucagon-like peptide-2, enteroendocrine cells, alpha-gustducin, enteric neurons, gastrointestinal hormones, horses, dietary carbohydrates, hydration
- MeSH terms
- Amino Acid Sequence, Animals, Biological Transport, Cats, Dietary Carbohydrates, Energy Metabolism, Epithelial Cells, Female, Glucose, Horses, Intestine, Small, Male, Molecular Sequence Data, Swine, Tongue, Transducin, Enteroendocrine Cells, Receptors, G-Protein-Coupled, Sodium-Glucose Transporter 1, Glucagon-Like Peptide 2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
