The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Identification of many microRNAs that copurify with polyribosomes in mammalian neurons
Open accessAbstract
Localized translation in mammalian dendrites may play a role in synaptic plasticity and contribute to the molecular basis for learning and memory. The regulatory mechanisms that control localized translation in neurons are not well understood. We propose a role for microRNAs (miRNAs), a class of noncoding RNAs, as mediators of neuronal translational regulation. We have identified 86 miRNAs expressed in mammalian neurons, of which 40 have not previously been reported. A subset of these miRNAs exhibits temporally regulated expression in cortical cultures. Moreover, all of the miRNAs that were tested cofractionate with polyribosomes, the sites of active translation. These findings indicate that a large, diverse population of miRNAs may function to regulate translation in mammalian neurons.
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“Compared with other organs, the brain has a particularly high percentage of tissue-specific and tissue-enriched miR-NAs (Lagos-Quintana et al., 2002;Kim et al., 2004;Sempere et al., 2004;Smirnova et al., 2005).”
From Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes (2013) · cites this paper as Kim et al., 2004
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The microRNAs of Caenorhabditis elegans
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Cited by
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714
MicroRNAs: small RNAs with a big role in gene regulation
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(2008) · doi:10.1038/nrg2290 · Cited by 5,199
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Metadata
- Authors
- Kim, J., Krichevsky, A., Grad, Y., Hayes, G. D., Kosik, K. S., Church, G. M., & Ruvkun, G.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-12-22
- Volume
- 101
- Issue
- 1
- Pages
- 360-365
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060317992
- Cited by
- 569
- References
- 13
- FWCI
- 15.03
- Type
- journal article
- Language
- en
- Open access
- green
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- Kim, J., Krichevsky, A., Grad, Y., Hayes, G. D., Kosik, K. S., Church, G. M., & Ruvkun, G. (2004). Identification of many microRNAs that copurify with polyribosomes in mammalian neurons. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2333854100
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