The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor
Open accessAbstract
The glucocorticoid receptor (GR) activates or represses transcription depending on the sequence and architecture of the glucocorticoid response elements in target genes and the availability and activity of interacting cofactors. Numerous GR cofactors have been identified, but they alone are insufficient to dictate the specificity of GR action. Furthermore, the role of different functional surfaces on the receptor itself in regulating its targets is unclear, due in part to the paucity of known target genes. Using DNA microarrays and real-time quantitative PCR, we identified genes transcriptionally activated by GR, in a translation-independent manner, in two human cell lines. We then assessed in U2OS osteosarcoma cells the consequences of individually disrupting three GR domains, the N-terminal activation function (AF) 1, the C-terminal AF2, or the dimer interface, on activation of these genes. We found that GR targets differed in their requirements for AF1 or AF2, and that the dimer interface was dispensable for activation of some genes in each class. Thus, in a single cell type, different GR surfaces were used in a gene-specific manner. These findings have strong implications for the nature of gene response element signaling, the composition and structure of regulatory complexes, and the mechanisms of context-specific transcriptional regulation.
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Cites
Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
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Cited by
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Self-citationDNA binding site sequence directs glucocorticoid receptor structure and activity
Meijsing, S. H., Pufall, M. A., So, A. Y., Bates, D. L., Chen, L., & Yamamoto, K. R. (2009) · Science · doi:10.1126/science.1164265 · Cited by 673
Self-citationGlucocorticoid receptor control of transcription: precision and plasticity via allostery
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Metadata
- Authors
- Rogatsky, I., Wang, J.-C., Derynck, M. K., Nonaka, D. F., Khodabakhsh, D. B., Haqq, C. M., Darimont, B. D., Garabedian, M. J., & Yamamoto, K. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2003-11-14
- Volume
- 100
- Issue
- 24
- Pages
- 13845-13850
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035254675
- Cited by
- 241
- References
- 10
- FWCI
- 8.71
- Type
- journal article
- Language
- en
- Open access
- green
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- Rogatsky, I., Wang, J.-C., Derynck, M. K., Nonaka, D. F., Khodabakhsh, D. B., Haqq, C. M., Darimont, B. D., Garabedian, M. J., & Yamamoto, K. R. (2003). Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2336092100
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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