The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Pro-coagulant state resulting from high levels of soluble P-selectin in blood
Open accessAbstract
The plasma concentration of soluble adhesion receptors is increased under pathological circumstances, but their function remains enigmatic. Soluble P-selectin (sP-sel) is shed from activated platelets and endothelial cells. Mice genetically engineered to express P-selectin without the cytoplasmic tail (ΔCT) constitutively show a 3- to 4-fold increase of sP-sel in plasma. We observed that the ΔCT mice formed fibrin very readily. In an ex vivo perfusion chamber, there was more fibrin deposited at the site of platelet thrombus formation than in wild type (WT), whereas no fibrin deposits were detected using P-selectin-deficient blood during the same interval. Similarly,in vivo, the hemorrhage produced by local Shwartzman reaction was smaller in the ΔCT mice than in WT. In contrast, we previously showed hemorrhage to be more prominent in P-selectin knock-out mice. Infusion of mouse P-sel-Ig chimera produced the same protective effect in WT mice as seen in the ΔCT mice, indicating that the effect was due to increased levels of sP-sel. Mice infused with P-sel-Ig showed significantly more fibrin deposited on the luminal face of the injured vessels than control mice. Plasma from ΔCT mice or mice infused with P-sel-Ig contained higher concentration of pro-coagulant microparticles and clotted one minute faster than WT. This pro-coagulant phenotype of ΔCT mice could be reversed by a 4-day treatment with PSGL-Ig, a P-selectin inhibitor. We propose that sP-sel should no longer be considered only as a marker of inflammation or platelet activation, but also as a direct inducer of pro-coagulant activity associated with vascular and thrombotic diseases.
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Cites
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Leukocyte rolling and extravasation are severely compromised in P selectin-deficient mice
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Self-citationBlood-borne tissue factor: Another view of thrombosis
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Cellular origin and procoagulant properties of microparticles in meningococcal sepsis
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Cited by
Epidemiology of venous thromboembolism
Heit, J. A. (2015) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2015.83 · Cited by 1,277
Demers, M., Krause, D. S., Schatzberg, D., Martinod, K., Voorhees, J. R., Fuchs, T. A., Scadden, D. T., & Wagner, D. D. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1200419109 · Cited by 883
Self-citationSelectins: initiators of leucocyte adhesion and signalling at the vascular wall
McEver, R. P. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv154 · Cited by 575
Platelets in inflammation and thrombosis
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P-selectin promotes neutrophil extracellular trap formation in mice
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Self-citation
Metadata
- Authors
- André, P., Hartwell, D., Hrachovinová, I., Saffaripour, S., & Wagner, D. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 2000-11-28
- Volume
- 97
- Issue
- 25
- Pages
- 13835-13840
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048213435
- Cited by
- 317
- References
- 43
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- green
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