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SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Open accessAbstract
Jun N-terminal kinase (JNK) is a stress-activated protein kinase that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation, and hypoxia. We report the identification of an anthrapyrazolone series with significant inhibition of JNK1, -2, and -3 ( K i = 0.19 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 dose dependently inhibited the phosphorylation of c-Jun, the expression of inflammatory genes COX-2 , IL-2 , IFN -γ, TNF -α, and prevented the activation and differentiation of primary human CD4 cell cultures. In animal studies, SP600125 blocked (bacterial) lipopolysaccharide-induced expression of tumor necrosis factor-α and inhibited anti-CD3-induced apoptosis of CD4 + CD8 + thymocytes. Our study supports targeting JNK as an important strategy in inflammatory disease, apoptotic cell death, and cancer.
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“In in vivo studies in mice, SP600125 inhibited lipopolysaccharide-induced expression of TNFa and prevented anti-CD3-mediated thymocyte apoptosis (Bennett et al , 2001).”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bennett et al , 2001
In the citing paper
“In cells, SP600125 dose-dependently inhibited the phosphorylation of c-jun, the expression of inflammatory genes COX-2, IL2, IHNg , and TNFa , and prevented the activation and differentiation of human CD4 cell.”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bennett et al , 2001
In the citing paper
“This result is very consistent with the previous structure-activity relationship studies, which revealed that all of the derivatives having N-alkyl substituents instead of the free NH group at the 2-position showed significant loss in inhibitory activity (Bennett et al , 2001).”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bennett et al , 2001
In the citing paper
“SP600125 is a reversible ATPcompetitive inhibitor with more than 20-fold selectivity over other kinases including Erk, p38 MAPKs, MKKs, and PKCs.”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bennett et al , 2001
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Cites
Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., & Riccardi, C. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90198-o · Cited by 4,562
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
Lee, J. C., Laydon, J. T., McDonnell, P., Gallagher, T. F., Kumar, S., Green, D., McNulty, D. E., Blumenthal, M. J., Keys, J., vatter, S. W. L., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,266
Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,423
[6] Statistical analysis of enzyme kinetic data
Cleland, W. W. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)63008-2 · Cited by 1,990
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538
Selective interaction of JNK protein kinase isoforms with transcription factors.
Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., & Davis, R. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00636.x · Cited by 1,341
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rinócn, M., Zheng, T. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1997) · Nature · doi:10.1038/39899 · Cited by 1,230
Oncogene jun encodes a sequence-specific trans- activator similar to AP-1
Angel, P., Allegretto, E. A., Okino, S. T., Hattori, K., Boyle, W. J., Hunter, T., & Karin, M. (1988) · Nature · doi:10.1038/332166a0 · Cited by 907
Research works printed but not linked: 2
- G McMahon, L Sun, C Liang, C Tang Curr Opin Drug Discovery Dev 1, 131–146 (1998).
- J A Hartley, K Reszka, E T Zuo, W D Wilson, A R Morgan, J W Lown Mol Pharmacol 33, 265–271 (1988).
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Robitaille, K., Daviau, A., Lachance, G., Couture, J.-P., & Blouin, R. (2008) · Cell Death & Differentiation · doi:10.1038/cdd.2008.77 · Cited by 47
Ramnath, R. D., Sun, J. T., Adhikari, S., & Bhatia, M. (2007) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2007.00086.x · Cited by 47
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Chen, F., Beezhold, K., & Castranova, V. (2009) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2009.06.005 · Cited by 47
Hoepner, R., Bagnoud, M., Pistor, M., Salmen, A., Briner, M., Synn, H., Schrewe, L., Guse, K., Ahmadi, F., Demir, S., et al. (2019) · Acta Neuropathologica · doi:10.1007/s00401-019-02018-8 · Cited by 47
Mulder, S. E., Dasgupta, A., King, R. J., Abrego, J., Attri, K. S., Murthy, D., Shukla, S. K., & Singh, P. K. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.07.025 · Cited by 47
JNK activation contributes to DP5 induction and apoptosis following traumatic spinal cord injury
Yin, K., Kim, G.-M., Lee, J., He, Y. Y., Xu, J., & Hsu, C. Y. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.05.026 · Cited by 47
Dirsch, V. M., Kirschke, S. O., Estermeier, M., Steffan, B., & Vollmar, A. M. (2003) · Oncogene · doi:10.1038/sj.onc.1207281 · Cited by 47
Induction of cyclooxygenase-2 expression by manganese in cultured astrocytes
LIAO, S., OU, Y., Chen, S., CHIANG, A., & Chen, C. (2006) · Neurochemistry International · doi:10.1016/j.neuint.2006.09.016 · Cited by 47
Increased expression of soluble decoy receptor 3 in acutely inflamed intestinal epithelia
Kim, S. W., Fotiadu, A., & Kotoula, V. (2005) · Clinical Immunology · doi:10.1016/j.clim.2005.02.014 · Cited by 47
Polychaete trunk neuroectoderm converges and extends by mediolateral cell intercalation
Steinmetz, P. R. H., González, F. Z., Burgtorf, C., Wittbrodt, J., & Arendt, D. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606589104 · Cited by 47
Tumor Necrosis Factor Receptor 1/c-Jun-NH2-Kinase Signaling Promotes Human Neoplasia
Zhang, J. Y., Adams, A. E., Ridky, T. W., Tao, S., & Khavari, P. A. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4017 · Cited by 47
Tagoe, C. E., Marjanović, N., Park, J. Y., Chan, E. S. L., Abeles, A. M., Attur, M. G., Abramson, S. B., & Pillinger, M. H. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2813 · Cited by 46
Sanalkumar, R., Pillai, I. C. L., Divya, T. S., Sivaraman, D. M., Anto, R. J., Balachandran, V., Sasidharan, V., Jagatha, B., Venugopal, S., & James, J. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06574.x · Cited by 46
Cao, J., Gao, H., Bemis, G. W., Salituro, F. G., Ledeboer, M. W., Harrington, E. M., Wilke, S., Taslimi, P. M., Pazhanisamy, S., Xie, X., et al. (2009) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2009.03.043 · Cited by 46
Deng, S., Yan, T., Nikolova, T., Fuhrmann, D. C., Nemecek, A., Gödtel‐Armbrust, U., Kaina, B., & Wojnowski, L. (2014) · British Journal of Pharmacology · doi:10.1111/bph.13046 · Cited by 47
Activation of the stress proteome as a mechanism for small molecule therapeutics
Brose, R. D., Shin, G., McGuinness, M. C., Schneidereith, T., Purvis, S. H., Dong, G.-X., Keefer, J. R., Spencer, F. A., & Smith, K. D. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds247 · Cited by 45
Midazolam suppresses interleukin-1β-induced interleukin-6 release from rat glial cells
Tanabe, K., Kozawa, O., & Iida, H. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-68 · Cited by 46
Murakami, Y., Aizu-Yokota, E., Sonoda, Y., Ohta, S., & Kasahara, T. (2006) · The Journal of Biochemistry · doi:10.1093/jb/mvm044 · Cited by 46
Marshall, R. M., Salerno, D. M., Garriga, J., & Graña, X. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.6402 · Cited by 46
Gong, Z., Kuang, Z., Li, H., Li, C., Ali, M. K., Huang, F., Li, P., Li, Q., Huang, X. S., Ren, S., et al. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.10.009 · Cited by 46
Qiu, L., Wang, M., Hu, S., Ru, X., Ren, Y., Zhang, Z., Yu, S., & Zhang, Y. (2018) · Cancers · doi:10.3390/cancers10120520 · Cited by 46
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Lei, L., Yang, J., Zhang, J., & Zhang, G. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101880 · Cited by 46
Nieminen, R. M., Lahti, A., Jalonen, U., Kankaanranta, H., & Moilanen, E. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.01.009 · Cited by 45
Chou, S.-F., Chang, S., & Chuang, J.-L. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-0835 · Cited by 46
Impact of Fever-Range Thermal Stress on Lymphocyte-Endothelial Adhesion and Lymphocyte Trafficking
Appenheimer, M. M., Chen, Q., Girard, R. A., Wang, W., & Evans, S. S. (2005) · Immunological Investigations · doi:10.1081/imm-200064501 · Cited by 47
Coleman, M. L., Densham, R. M., Croft, D. R., & Olson, M. F. (2005) · Oncogene · doi:10.1038/sj.onc.1209322 · Cited by 44
Xu, Q., Hou, W., Zheng, Y., Liu, C., Gong, Z., Lu, C., Lai, W., & Maibach, H. I. (2014) · PLoS ONE · doi:10.1371/journal.pone.0102732 · Cited by 46
Glycogen synthase kinase-3 inhibitors augment TRAIL-induced apoptotic death in human hepatoma cells
Beurel, E., Eggelpoël, M.-J. B.-V., Kornprobst, M., Moritz, S., Delelo, R., Paye, F., Housset, C., & Desbois‐Mouthon, C. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.09.026 · Cited by 46
Zapata, H. J., Nakatsugawa, M., & Moffat, J. F. (2006) · Journal of Virology · doi:10.1128/jvi.01470-06 · Cited by 46
The Down Syndrome Cell Adhesion Molecule (DSCAM) Interacts with and Activates Pak
Li, W., & Guan, K. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m401878200 · Cited by 46
RetractedMasamune, A., Kikuta, K., Suzuki, N., Satoh, M., Satoh, K., & Shimosegawa, T. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.067280 · Cited by 46
Murphy, B. M., Engel, T., Paucard, A., Hatazaki, S., Mouri, G., Tanaka, K., Tuffy, L. P., Jimenez-Mateos, E. M., Woods, I., Dunleavy, M., et al. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.134 · Cited by 45
Jun Kinase Delays Caspase-9 Activation by Interaction with the Apoptosome
Tran, T., Andreka, P. G., Rodrigues, C. O., Webster, K. A., & Bishopric, N. H. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702210200 · Cited by 45
Okudaira, N., Iijima, K., Koyama, T., Minemoto, Y., Kano, S., Mimori, A., & Ishizaka, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001252107 · Cited by 50
Vitamin D and Death by Sunshine
Dixon, K. M., Tongkao‐on, W., Sequeira, V. B., Carter, S. E., Song, E., Rybchyn, M. S., Gordon‐Thomson, C., & Mason, R. S. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14011964 · Cited by 45
Ho, I.-L., Kuo, K.-L., Liu, S., Chang, H., Hsieh, J., Wu, J., Chiang, C., Lin, W., Tsai, Y., Chou, C.-T., et al. (2015) · Scientific Reports · doi:10.1038/srep16948 · Cited by 45
Niu, W., Wang, Y., Wang, Z., Xin, Q., Wang, Y., Feng, L., Zhao, L., Wen, J., Zhang, H., Wang, C., et al. (2016) · Development · doi:10.1242/dev.132175 · Cited by 45
Role of C-Jun N-terminal Kinase in Hepatocellular Carcinoma Development
Wang, J., & Tai, G. (2016) · Targeted Oncology · doi:10.1007/s11523-016-0446-5 · Cited by 46
Carroll, D. J., O’Sullivan, J. A., Nix, D. B., Cao, Y., Tiemeyer, M., & Bochner, B. S. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.08.013 · Cited by 47
Deng, Z., Yuan, C., Yang, J. M., Peng, Y., Wang, W., Wang, Y., & Gao, W. (2019) · Annals of Translational Medicine · doi:10.21037/atm.2018.12.08 · Cited by 45
Injury-induced MAPK activation triggers body axis formation in Hydra by default Wnt signaling
Tursch, A., Bartsch, N., Mercker, M., Schlüter, J., Lommel, M., Marciniak-Czochra, A. K., Özbek, S., & Holstein, T. W. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204122119 · Cited by 58
Smad3 phosphoisoform-mediated signaling during sporadic human colorectal carcinogenesis.
Matsuzaki, K. (2006) · PubMed · doi:10.14670/hh-21.645 · Cited by 45
Persichini, T., Maio, N., di Patti, M. C. B., Rizzo, G., Colasanti, M., & Musci, G. (2010) · Neuroscience Letters · doi:10.1016/j.neulet.2010.08.034 · Cited by 44
Mei, Y., Yuan, Z., Song, B., Li, D., Ma, C., Hu, C., Ching, Y.-P., & Li, M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.057 · Cited by 45
Abidi, P., Leers‐Sucheta, S., Cortez, Y., Han, J., & Azhar, S. (2007) · Aging Cell · doi:10.1111/j.1474-9726.2007.00364.x · Cited by 45
Carmona, E. M., Lamont, J. D., Xue, A., Wylam, M. E., & LIMPER, A. H. (2010) · Respiratory Research · doi:10.1186/1465-9921-11-95 · Cited by 45
Lim, W., Gee, K., Mishra, S., & Kumar, A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.9.5690 · Cited by 45
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Little, J. P., Madeira, J. M., & Klegeris, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111262 · Cited by 45
Yang, X., Yao, J. J., Luo, Y., Han, Y., Wang, Z., & Du, L. (2013) · Journal of Pharmacological Sciences · doi:10.1254/jphs.12234fp · Cited by 44
Mion, F., Tonon, S., Toffoletto, B., Cesselli, D., Pucillo, C., & Vitale, G. (2014) · Molecular Immunology · doi:10.1016/j.molimm.2014.05.018 · Cited by 42
Lü, Y., Chen, T., Wang, X., Qu, J., & Chen, M. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.08.014 · Cited by 45
Okada, M., Shibuya, K., Sato, A., Seino, S., WATANABE, E., Suzuki, S., Seino, M., & Kitanaka, C. (2013) · Oncology Reports · doi:10.3892/or.2013.2655 · Cited by 44
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Wang, Y., Zhang, Y., Wei, Z., Li, H., Zhou, H., Zhang, Z., & Zhang, Z. (2009) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2009.06.034 · Cited by 44
Ikeda, R., Yanagisawa, M., Takahashi, N., Kawada, T., Kumazawa, S., Yamaotsu, N., Nakagome, I., Hirono, S., & Tsuda, T. (2011) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2011.04.007 · Cited by 44
Lin, W., Luo, S., Lee, C., Wang, C.-C., Wang, J., & Yang, C. (2007) · Cellular Signalling · doi:10.1016/j.cellsig.2007.01.009 · Cited by 44
Ramseyer, V. D., Hong, N. J., & Garvin, J. L. (2012) · Hypertension · doi:10.1161/hypertensionaha.111.189761 · Cited by 43
LaRosa, C., & Downs, S. M. (2006) · Biology of Reproduction · doi:10.1095/biolreprod.106.057422 · Cited by 44
Wang, J., Guo, Z., Fu, Y., Wu, Z., Huang, C., Zheng, C., Shar, P. A., Wang, Z., Xiao, W., & Wang, Y. (2016) · Briefings in Bioinformatics · doi:10.1093/bib/bbw018 · Cited by 44
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Bajpai, A. K., Blaskova, E., Pakala, S. B., Zhao, T., Glasgow, W. C., Penn, J. S., Johnson, D. A., & Rao, G. N. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-0617 · Cited by 44
Park, K. M., Yule, D. I., & Bowers, W. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m802209200 · Cited by 44
Joesting, M. S., Cheever, T. R., Volzing, K., Yamaguchi, T. P., Wolf, V., Näf, D., Rubin, J. S., & Marker, P. C. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.02.021 · Cited by 44
Tsukamoto, N., Otsuka, F., Miyoshi, T., Yamanaka, R., Inagaki, K., Yamashita, M., Otani, H., Takeda, M., Suzuki, J., Ogura, T., et al. (2010) · Endocrinology · doi:10.1210/en.2009-1102 · Cited by 44
Eynott, P. R., Xu, L., Bennett, B. L., Noble, A., Leung, S., Nath, P., Groneberg, D. A., Adcock, I. M., & Chung, K. F. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01887.x · Cited by 43
Self-citationJun N-terminal kinase is essential for CD40-mediated IgE class switching in B cells
Jabara, H. H., & Geha, R. S. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.01.020 · Cited by 44
Undevia, N. S., Dorscheid, D. R., Marroquin, B. A., Gugliotta, W. L., Tse, R., & White, S. R. (2004) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00044.2004 · Cited by 45
Babilonia, E., Li, D., Wang, Z., Sun, P., Lin, D., Jin, Y., & Wang, W. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2006050426 · Cited by 42
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Taru, H., & Suzuki, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312007200 · Cited by 44
García, M., Charvin, D., & Caboche, J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.054 · Cited by 44
Cho, C., Oh, H., Lee, J. S., Kang, L., Oh, E.-J., Hwang, Y., Kim, S. J., Bae, Y., Kim, E., Kang, H. C., et al. (2023) · Biomaterials · doi:10.1016/j.biomaterials.2023.122131 · Cited by 43
Many, A. M., & Brown, A. M. C. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101800 · Cited by 45
Wei, Z. Z., Yu, S. P., Lee, J. H., Chen, D., Taylor, T. M., Deveau, T. C., Yu, A. C., & Wei, L. (2014) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-014-0067-4 · Cited by 43
Figueiredo, C., Pais, T. F., Gomes, J. R., & Chatterjee, S. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05577.x · Cited by 43
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A human ribonuclease induces apoptosis associated with p21WAF1/CIP1induction and JNK inactivation
Castro, J., Ribó, M., Navarro, S., Nogués, M. V., Vilanova, M., & Benito, A. (2011) · BMC Cancer · doi:10.1186/1471-2407-11-9 · Cited by 43
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Marra, F., Delogu, W., Petrai, I., Pastacaldi, S., Bonacchi, A., Efsen, E., Aleffi, S., Bertolani, C., Pinzani, M., & Geñtilini, P. (2004) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00336.2003 · Cited by 43
Kakita, A., Suzuki, A., Nishiwaki-Yasuda, K., Ono, Y., Kotake, M., Ariyoshi, Y., Miura, Y., ltoh, M., & Oiso, Y. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2003.12.039 · Cited by 43
Inhibiting autophagy overcomes docetaxel resistance in castration-resistant prostate cancer cells
Wang, Q., He, W., Zeng, Y., Hossain, A., & Gou, X. (2018) · International Urology and Nephrology · doi:10.1007/s11255-018-1801-5 · Cited by 44
TNF-α controls Lipocalin-2 expression in PC-3 prostate cancer cells
Schröder, S. K., Asimakopoulou, A., Tillmann, S., Koschmieder, S., & Weiskirchen, R. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155214 · Cited by 43
Jordà, E. G., Verdaguer, E., Canudas, A. M., Jiménez, A., Bruna, A., Caelles, C., Bravo, R., Escubedo, E., Pubill, D., Camarasa, J., et al. (2003) · Neuropharmacology · doi:10.1016/s0028-3908(03)00204-1 · Cited by 44
Pratsinis, H., Giannouli, C. C., Zervolea, I., Psarras, S., Stathakos, D., & Kletsas, D. (2004) · Wound Repair and Regeneration · doi:10.1111/j.1067-1927.2004.12305.x · Cited by 43
Sugiura, T., Tazaki, A., Ueno, N., Watanabe, K., & Mochii, M. (2008) · Mechanisms of Development · doi:10.1016/j.mod.2008.10.002 · Cited by 43
Lupo, G., Nicotra, A., Giurdanella, G., Anfuso, C. D., Romeo, L., Biondi, G., Tirolo, C., Marchetti, B., Ragusa, N., & Alberghina, M. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2005.05.008 · Cited by 43
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Bogoyevitch, M. A. (2005) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2005.03.005 · Cited by 43
Rabiéga, P., Bardel, É., Dietrich, C., Kastelein, R., & Devergne, O. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.221010 · Cited by 43
You, J.-J., Yang, C., Chen, M., & Yang, C. (2010) · Experimental Eye Research · doi:10.1016/j.exer.2010.10.006 · Cited by 43
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Lombardi, C., Senna, G., Gatti, B. B., Feligioni, M., Riva, G., Bonadonna, R. C., Dama, A. R., Canonica, G. W., & Passalacqua, G. (1998) · PubMed · Cited by 43
Teraishi, F., Wu, S., Zhang, L., Guo, W., Davis, J. J., Dong, F., & Fang, B. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0575 · Cited by 43
Zhai, W., Eynott, P. R., Oltmanns, U., Leung, S. Y., & Chung, K. F. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705971 · Cited by 43
Stress-Activated Protein Kinases Mediate Cell Migration in Human Airway Epithelial Cells
White, S. R., Tse, R., & Marroquin, B. A. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2004-0118oc · Cited by 43
Laufer, R. S., Ng, G., Liu, Y., Patel, N. K., Edwards, L. G., Lang, Y., Li, S.-W., Fehér, M., Awrey, D. E., Leung, G. C., et al. (2014) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2014.06.027 · Cited by 42
Jiang, C., Zhu, Y., Chen, H., Lin, J., Xie, R., Li, W., Xue, J., Chen, L., Chen, X., & Xu, S. (2023) · Cell Death & Disease · doi:10.1038/s41419-023-06181-5 · Cited by 36
Metadata
- Authors
- Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S. S., Manning, A. M., & Anderson, D. W.
- Affiliations
- Signal Research Division, Celgene Corporation, 5555 Oberlin Drive, San Diego, CA 92121
- Yale University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-11-20
- Volume
- 98
- Issue
- 24
- Pages
- 13681-13686
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC61101
- OpenAlex
- W2096931514
- Cited by
- 2,558
- References
- 46
- Citations by year
- 2026: 40 · 2025: 49 · 2024: 77 · 2023: 66 · 2022: 51 · 2021: 69 · 2020: 71 · 2019: 52 · 2018: 60 · 2017: 91 · 2016: 97 · 2015: 80 · 2014: 100 · 2013: 107 · 2012: 132
- FWCI
- 47.43
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- SP600125, Jun N-terminal kinase, ATP-competitive kinase inhibitors, c-Jun phosphorylation, inflammatory gene expression, cyclooxygenase-2, TNF-α, lipopolysaccharide, CD4+ T cell activation, apoptosis, thymocytes, inflammatory diseases, cancer
- MeSH terms
- Adenosine Triphosphate, Animals, Anthracenes, Anthraquinones, Binding, Competitive, Cell Differentiation, Cells, Cultured, Enzyme Inhibitors, Female, Humans, Lymphocyte Activation, Mice, Inbred C57BL, Monocytes, Pyrazoles, Structure-Activity Relationship, Tumor Necrosis Factor-alpha, Molecular Structure, CD4-Positive T-Lymphocytes, Gene Expression, Cytokines, Jurkat Cells, Mitogen-Activated Protein Kinases, Pyrazolones, Protein Kinase Inhibitors, JNK Mitogen-Activated Protein Kinases, Mice
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