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JNK activation is essential for activation of MEK/ERK signaling in IL-1β-induced COX-2 expression in synovial fibroblasts

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Involvement of the JNK‐like protein of the Aedes albopictus mosquito cell line, C6/36, in phagocytosis, endocytosis and infection of West Nile virus

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Bone morphogenetic protein-4 abrogates lumen formation by mammary epithelial cells and promotes invasive growth

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c-Jun NH2-Terminal Kinase-Mediated Signaling Is Essential forPseudomonas aeruginosaExoS-Induced Apoptosis

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Systems Biology Analyses Show Hyperactivation of Transforming Growth Factor-β and JNK Signaling Pathways in Esophageal Cancer

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Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells

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JNK pathway may be involved in isoflurane-induced apoptosis in the hippocampi of neonatal rats

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Activation of PI3K/Akt pathway limits JNK-mediated apoptosis during EV71 infection

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Proteomic Identification of Bcl2-associated Athanogene 2 as a Novel MAPK-activated Protein Kinase 2 Substrate

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Multi-walled carbon nanotube length as a critical determinant of bioreactivity with primary human pulmonary alveolar cells

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P53 activation plays a crucial role in silibinin induced ROS generation via PUMA and JNK

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Hepatitis C virus Core protein stimulates cell growth by down-regulating p16 expression via DNA methylation

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Protein Kinase Inhibitors: Structural Insights Into Selectivity

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Oxidant-Mediated Mitochondrial Injury in Eosinophil Apoptosis: Enhancement by Glucocorticoids and Inhibition by Granulocyte-Macrophage Colony-Stimulating Factor

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Phosphorylation of the Retinoid X Receptor at the Omega loop, modulates the expression of retinoic-acid-target genes with a promoter context specificity

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Phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase regulate induction of Mcl-1 and survival in glucocorticoid-treated human neutrophils

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Post-Transcriptional Regulation of Human Inducible Nitric-Oxide Synthase Expression by the Jun N-terminal Kinase

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Sustained JNK Activation in Response to Tumor Necrosis Factor Is Mediated by Caspases in a Cell Type-specific Manner

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Poliovirus Induces Bax-Dependent Cell Death Mediated by c-Jun NH 2 -Terminal Kinase

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Response of Non–Small Cell Lung Cancer Cells to the Inhibitors of Phosphatidylinositol 3-Kinase/Akt- and MAPK Kinase 4/c-Jun NH2-Terminal Kinase Pathways: An Effective Therapeutic Strategy for Lung Cancer

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A Signaling Mechanism from Gαq-Protein-Coupled Metabotropic Glutamate Receptors to Gene Expression: Role of the c-Jun N-Terminal Kinase Pathway

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Rheumatoid Arthritis and Reactive Oxygen Species: A Review

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Cdc6 and Cyclin E2 Are PTEN-Regulated Genes Associated with Human Prostate Cancer Metastasis

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Expression of PUMA in Follicular Granulosa Cells Regulated by FoxO1 Activation During Oxidative Stress

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Aldosterone Stimulates Elastogenesis in Cardiac Fibroblasts via Mineralocorticoid Receptor-independent Action Involving the Consecutive Activation of Gα13, c-Src, the Insulin-like Growth Factor-I Receptor, and Phosphatidylinositol 3-Kinase/Akt

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AEG3482 Is an Antiapoptotic Compound that Inhibits Jun Kinase Activity and Cell Death through Induced Expression of Heat Shock Protein 70

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Venus Kinase Receptors Control Reproduction in the Platyhelminth Parasite Schistosoma mansoni

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Indazole-Based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125)

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Ubiquitin-specific protease 14 regulates c-Jun N-terminal kinase signaling at the neuromuscular junction

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Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-α in IEC-6 cells

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Eosinophil Cysteinyl Leukotriene Synthesis Mediated by Exogenous Secreted Phospholipase A2 Group X

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Oxidative stress‐induced c‐Jun N‐terminal kinase (JNK) activation in tendon cells upregulates MMP1 mRNA and protein expression

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Fibroblast growth factor 2 (FGF2) regulates cytoglobin expression and activation of human hepatic stellate cells via JNK signaling

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Inflammatory Cytokine Expression Is Independent of the c-Jun N-Terminal Kinase/AP-1 Signaling Cascade in Human Neutrophils

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Induction of C/EBPβ and GADD153 expression by dopamine in human neuroblastoma cells

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JNK/c-Jun signaling pathway mediates the fluoride-induced down-regulation of MMP-20 in vitro

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Novel synergistic mechanism for sst2 somatostatin and TNFα receptors to induce apoptosis: crosstalk between NF-κB and JNK pathways

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Disruption of JNK2 Decreases the Cytokine Response to Plasmodium falciparum Glycosylphosphatidylinositol In Vitro and Confers Protection in a Cerebral Malaria Model

Lu, Z., Serghides, L., Patel, S. N., Degousée, N., Rubin, B. B., Gowda, K., Gowda, D. C., Karin, M., & Kain, K. C. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6344 · Cited by 51

Effects of SAPK/JNK inhibitors on preimplantation mouse embryo development are influenced greatly by the amount of stress induced by the media

Xie, Y., Puscheck, E. E., & Rappolee, D. A. (2006) · Molecular Human Reproduction · doi:10.1093/molehr/gal021 · Cited by 51

Oncostatin M causes eotaxin-1 release from airway smooth muscle: Synergy with IL-4 and IL-13

Faffe, D. S., Flynt, L., Mellema, M. S., Moore, P. E., Silverman, E. S., Subramaniam, V., Jones, M. R., Mizgerd, J. P., Whitehead, T. R., Imrich, A., et al. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.11.033 · Cited by 51

A role for UV-light-induced c-Fos: stimulation of nucleotide excision repair and protection against sustained JNK activation and apoptosis

Christmann, M., Tomicic, M. T., Aasland, D., & Kaina, B. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl119 · Cited by 51

Enhancing chemosensitivity to gemcitabine via RNA interference targeting the catalytic subunits of protein kinase CK2 in human pancreatic cancer cells

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c-Jun N-terminal kinase activation in dorsal root ganglion contributes to pain hypersensitivity

Doya, H., Ohtori, S., Fujitani, M., Saito, T., Hata, K., Ino, H., Takahashi, K., Moriya, H., & Yamashita, T. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.055 · Cited by 50

The Double-Stranded RNA Bluetongue Virus Induces Type I Interferon in Plasmacytoid Dendritic Cells via a MYD88-Dependent TLR7/8-Independent Signaling Pathway

Ruscanu, S., Pascale, F., Bourge, M., Hemati, B., Elhmouzi‐Younes, J., Urien, C., Bonneau, M., Takamatsu, H., Hope, J. C., Mertens, P., et al. (2012) · Journal of Virology · doi:10.1128/jvi.06716-11 · Cited by 50

N6‐isopentenyladenosine inhibits cell proliferation and induces apoptosis in a human colon cancer cell line DLD1

Laezza, C., Caruso, M. G., Gentile, T., Notarnicola, M., Malfitano, A. M., Matola, T. D., Messa, C., Gazzerro, P., & Bifulco, M. (2008) · International Journal of Cancer · doi:10.1002/ijc.24056 · Cited by 50

JNK Inhibitors As Anti-Inflammatory and Neuroprotective Agents

Graczyk, P. P. (2013) · Future Medicinal Chemistry · doi:10.4155/fmc.13.34 · Cited by 50

Functional Role of c-Jun-N-Terminal Kinase in Feeding Regulation

Unger, E. K., Piper, M. L., Olofsson, L. E., & Xu, A. W. (2009) · Endocrinology · doi:10.1210/en.2009-0711 · Cited by 50

The JNK inhibitor SP600129 enhances apoptosis of HCC cells induced by the tumor suppressor WWOX

Aderca, I., Moser, C. D., Veerasamy, M., BaniHani, A. H., Bonilla-Guerrero, R., Ahmed, K. H., Shire, A. M., Cazanave, S. C., Montoya, D. P., Mettler, T. A., et al. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.05.015 · Cited by 50

Upregulation of calcium-sensing receptor and mitogen-activated protein kinase signalling in the regulation of growth and differentiation in colon carcinoma

Bhagavathula, N., Kelley, E. A., Reddy, M., Nerusu, K. C., Leonard, C., Fay, K. S., Chakrabarty, S., & Varani, J. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602852 · Cited by 50

Negative Regulation of ASK1 by p21Cip1 Involves a Small Domain That Includes Serine 98 That Is Phosphorylated by ASK1 In Vivo

Zhan, J., Easton, J. B., Huang, S., Mishra, A., Xiao, L., Lacy, E. R., Kriwacki, R. W., & Houghton, P. J. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00086-06 · Cited by 50

TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy

Ábrigo, J., Campos, F., Simón, F., Riedel, C. A., Cabrera, D., Vilos, C., & Cabello‐Verrugio, C. (2017) · Biological Chemistry · doi:10.1515/hsz-2017-0217 · Cited by 50

The Amyloid-β Precursor Protein Is Phosphorylated via Distinct Pathways during Differentiation, Mitosis, Stress, and Degeneration

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Multiple mitogenic pathways in pancreatic cancer cells are blocked by a truncated epidermal growth factor receptor.

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Morusin exerts anti-cancer activity in renal cell carcinoma by disturbing MAPK signaling pathways

Yang, C., Luo, J., Luo, X., Jia, W., Fang, Z., Yi, S., & Li, L. (2020) · Annals of Translational Medicine · doi:10.21037/atm.2020.02.107 · Cited by 49

Notch4 mediates vascular remodeling via ERK/JNK/P38 MAPK signaling pathways in hypoxic pulmonary hypertension

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Therapeutic effect of c‐Jun N‐terminal kinase inhibition on pancreatic cancer

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C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy

Klein, S. R., Piya, S., Lu, Z., Xia, Y., Alonso, M. M., White, E. J., Wei, J., Gomez‐Manzano, C., Jiang, H., & Fueyo-Margareto, J. (2015) · Oncogene · doi:10.1038/onc.2014.452 · Cited by 49

Anti-nociceptive interactions between opioids and a cannabinoid receptor 2 agonist in inflammatory pain

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c-Jun Kinase Is a Critical Signaling Molecule in a Neonatal Model of Group B Streptococcal Sepsis

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An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from d-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins

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The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway

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Human pancreatic duct cells can produce tumour necrosis factor-α that damages neighbouring beta cells and activates dendritic cells

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Role of p38 Protein Kinase in the Ligand-independent Ubiquitination and Down-regulation of the IFNAR1 Chain of Type I Interferon Receptor

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Fibroblast growth factor-23 abolishes 1,25-dihydroxyvitamin D3-enhanced duodenal calcium transport in male mice

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Mycobacterium tuberculosis exploits the PPM1A signaling pathway to block host macrophage apoptosis

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JNK1 induces hedgehog signaling from stellate cells to accelerate liver regeneration in mice

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Mitogen‐activated protein kinase signaling mediates opioid‐induced presynaptic NMDA receptor activation and analgesic tolerance

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Mesenchymal Cell-Derived Juxtacrine Wnt1 Signaling Regulates Osteoblast Activity and Osteoclast Differentiation

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Lipopolysaccharide Up-Regulates MHC Class II Expression on Dendritic Cells through an AP-1 Enhancer without Affecting the Levels of CIITA

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Ephrin-B1 Reverse Signaling Activates JNK through a Novel Mechanism That Is Independent of Tyrosine Phosphorylation

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Arctic Ground Squirrel ( Spermophilus Parryii ) Hippocampal Neurons Tolerate Prolonged Oxygen—Glucose Deprivation and Maintain Baseline ERK1/2 and JNK Activation Despite Drastic ATP Loss

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Inhibition of c-Jun N-Terminal Kinase Limits Lipopolysaccharide-induced Pulmonary Neutrophil Influx

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Phosphorylation of MAP kinase-like proteins mediate the response of the halotolerant alga Dunaliella viridis to hypertonic shock

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Jun N-terminal kinase promotes proliferation of immature erythroid cells and erythropoietin-dependent cell lines

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Exposure of human corneal epithelial cells to contact lenses in vitro suppresses the upregulation of human β-defensin-2 in response to antigens of Pseudomonas aeruginosa

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Death receptor-4 (DR4) expression is regulated by transcription factor NF-κB in response to etoposide treatment

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Mitogen-activated Protein Kinase Phosphatase-1 Represses c-Jun NH2-terminal Kinase-mediated Apoptosis via NF-κB Regulation

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Leflunomide or A77 1726 protect from acetaminophen-induced cell injury through inhibition of JNK-mediated mitochondrial permeability transition in immortalized human hepatocytes

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