The DOI matches its Crossref record; 44 of the 46 references it cites were found in a registry or an index.
SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase
Open accessAbstract
Jun N-terminal kinase (JNK) is a stress-activated protein kinase that can be induced by inflammatory cytokines, bacterial endotoxin, osmotic shock, UV radiation, and hypoxia. We report the identification of an anthrapyrazolone series with significant inhibition of JNK1, -2, and -3 ( K i = 0.19 μM). SP600125 is a reversible ATP-competitive inhibitor with >20-fold selectivity vs. a range of kinases and enzymes tested. In cells, SP600125 dose dependently inhibited the phosphorylation of c-Jun, the expression of inflammatory genes COX-2 , IL-2 , IFN -γ, TNF -α, and prevented the activation and differentiation of primary human CD4 cell cultures. In animal studies, SP600125 blocked (bacterial) lipopolysaccharide-induced expression of tumor necrosis factor-α and inhibited anti-CD3-induced apoptosis of CD4 + CD8 + thymocytes. Our study supports targeting JNK as an important strategy in inflammatory disease, apoptotic cell death, and cancer.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In in vivo studies in mice, SP600125 inhibited lipopolysaccharide-induced expression of TNFa and prevented anti-CD3-mediated thymocyte apoptosis (Bennett et al , 2001).”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bennett et al , 2001
In the citing paper
“In cells, SP600125 dose-dependently inhibited the phosphorylation of c-jun, the expression of inflammatory genes COX-2, IL2, IHNg , and TNFa , and prevented the activation and differentiation of human CD4 cell.”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bennett et al , 2001
In the citing paper
“This result is very consistent with the previous structure-activity relationship studies, which revealed that all of the derivatives having N-alkyl substituents instead of the free NH group at the 2-position showed significant loss in inhibitory activity (Bennett et al , 2001).”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bennett et al , 2001
In the citing paper
“SP600125 is a reversible ATPcompetitive inhibitor with more than 20-fold selectivity over other kinases including Erk, p38 MAPKs, MKKs, and PKCs.”
From Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125 (2004) · cites this paper as Bennett et al , 2001
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Nicoletti, I., Migliorati, G., Pagliacci, M. C., Grignani, F., & Riccardi, C. (1991) · Journal of Immunological Methods · doi:10.1016/0022-1759(91)90198-o · Cited by 4,562
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
Lee, J. C., Laydon, J. T., McDonnell, P., Gallagher, T. F., Kumar, S., Green, D., McNulty, D. E., Blumenthal, M. J., Keys, J., vatter, S. W. L., et al. (1994) · Nature · doi:10.1038/372739a0 · Cited by 3,266
Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188
The Regulation of AP-1 Activity by Mitogen-activated Protein Kinases
Karin, M. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16483 · Cited by 2,423
[6] Statistical analysis of enzyme kinetic data
Cleland, W. W. (1979) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/0076-6879(79)63008-2 · Cited by 1,990
Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway
Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538
Selective interaction of JNK protein kinase isoforms with transcription factors.
Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., & Davis, R. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00636.x · Cited by 1,341
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
Yang, D. D., Kuan, C.-Y., Whitmarsh, A. J., Rinócn, M., Zheng, T. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1997) · Nature · doi:10.1038/39899 · Cited by 1,230
Oncogene jun encodes a sequence-specific trans- activator similar to AP-1
Angel, P., Allegretto, E. A., Okino, S. T., Hattori, K., Boyle, W. J., Hunter, T., & Karin, M. (1988) · Nature · doi:10.1038/332166a0 · Cited by 907
Research works printed but not linked: 2
- G McMahon, L Sun, C Liang, C Tang Curr Opin Drug Discovery Dev 1, 131–146 (1998).
- J A Hartley, K Reszka, E T Zuo, W D Wilson, A R Morgan, J W Lown Mol Pharmacol 33, 265–271 (1988).
Cited by
Sorted by citations
Items 301–400 of 1,010
Critical role of acidic sphingomyelinase in murine hepatic ischemia-reperfusion injury
Llacuna, L., Marı́, M., García‐Ruiz, C., Fernández-Checa, J. C., & Morales, A. (2006) · Hepatology · doi:10.1002/hep.21285 · Cited by 114
Li, L., Kim, J., & Boussiotis, V. A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001536 · Cited by 116
Alternative splicing of SYK regulates mitosis and cell survival
Prinos, P., Garneau, D., Lucier, J., Gendron, D., Couture, S., Boivin, M., Brosseau, J., Lapointe, E., Thibault, P., Durand, M., et al. (2011) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.2040 · Cited by 115
Suzuki, J.-I., Yamasaki, S., Wu, J. N., Koretzky, G. A., & Saito, T. (2006) · Blood · doi:10.1182/blood-2005-12-020164 · Cited by 114
Hocevar, B. A., Prunier, C., & Howe, P. H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501150200 · Cited by 97
Richardson, R. J., Metzger, M., Knyphausen, P., Ramezani, T., Slanchev, K., Kraus, C., Schmelzer, E., & Hammerschmidt, M. (2016) · Development · doi:10.1242/dev.130492 · Cited by 119
Endotoxaemia: a review with implications for the horse
Werners, A. H., Bull, S., & Fink‐Gremmels, J. (2005) · Equine Veterinary Journal · doi:10.2746/0425164054529418 · Cited by 114
Janes, K. A., Kelly, J., Gaudet, S., Albeck, J. G., Sorger, P. K., & Lauffenburger, D. A. (2004) · Journal of Computational Biology · doi:10.1089/cmb.2004.11.544 · Cited by 113
Tumor Cell Responses to a Novel Glutathione S-Transferase–Activated Nitric Oxide-Releasing Prodrug
Findlay, V. J., Townsend, D. M., Saavedra, J. E., Buzard, G. S., Citro, M. L., Keefer, L. K., Ji, X., & Tew, K. D. (2004) · Molecular Pharmacology · doi:10.1124/mol.65.5.1070 · Cited by 113
Utsugi, M., Dobashi, K., Ishizuka, T., Endou, K., Hamuro, J., Murata, Y., Nakazawa, T., & Mori, M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.2.628 · Cited by 112
Papp, L. V., Lu, J., Striebel, F., Kennedy, D. D., Holmgren, A., & Khanna, K. K. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02284-05 · Cited by 112
Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia
Zhang, Y., Yin, L., Anderson, J., Ma, H., Gonzalez, F. J., Willson, T. M., & Edwards, P. A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.083899 · Cited by 112
Zhang, S. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh234 · Cited by 113
Origlia, N., Bonadonna, C., Rosellini, A., Leznik, E., Arancio, O., Yan, S. S., & Domenici, L. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2127-10.2010 · Cited by 111
Wang, X., Chen, B., Sun, J., Jiang, Y., Zhang, H., Zhang, P., Fei, B., & Xu, Y. (2018) · Metabolism · doi:10.1016/j.metabol.2018.01.005 · Cited by 113
FGF15/FGFR4 Integrates Growth Factor Signaling with Hepatic Bile Acid Metabolism and Insulin Action
Shin, D.-J., & Osborne, T. F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m808747200 · Cited by 112
Dickkopf-1 antagonizes Wnt signaling independent of β-catenin in human mesothelioma
Lee, A. Y., He, B., You, L., Xu, Z., Mazières, J., Reguart, N., Mikami, I., Batra, S., & Jablons, D. M. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.09.001 · Cited by 111
Chen, Q., Wang, W., Bruce, R., Li, H., Schleider, D. M., Mulbury, M. J., Bain, M. D., Wallace, P. K., Baumann, H., & Evans, S. S. (2004) · Immunity · doi:10.1016/s1074-7613(03)00358-3 · Cited by 110
Zhai, C., Zhang, M.-Q., Zhang, Y., Xu, H., Wang, J., An, G., Wang, Y., & Li, L. (2012) · Acta Pharmacologica Sinica · doi:10.1038/aps.2012.112 · Cited by 113
Zhou, J., Liu, M., Aneja, R., Chandra, R., Lage, H., & Joshi, H. C. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-1779 · Cited by 112
Guan, Q., Pei, D., Liu, X., Wang, X., Xu, T., & Zhang, G. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.086 · Cited by 109
Yu, S., Zheng, W., Xin, N., Chi, Z., Wang, N.-Q., Nie, Y.-X., Feng, W., & Wang, Z. (2010) · Rejuvenation Research · doi:10.1089/rej.2009.0908 · Cited by 109
The MYD88-Independent Pathway Is Not Mobilized in Human Neutrophils Stimulated via TLR4
Tamassia, N., Moigne, V. L., Calzetti, F., Donini, M., Gasperini, S., Ear, T., Cloutier, A., Martínez, F. O., Fabbri, M., Locati, M., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.11.7344 · Cited by 110
Stretch-induced IL-8 depends on c-Jun NH2-terminal and nuclear factor-κB-inducing kinases
Li, L., Ouyang, B., Choukroun, G. J., Matyal, R., Mascarenhas, M. M., Jafari, B., Bonventre, J. V., Force, T. L., & Quinn, D. A. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00031.2003 · Cited by 110
Giri, R. K., Selvaraj, S. K., & Kalra, V. K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.10.5281 · Cited by 111
Comalada, M., Xaus, J., Valledor, A. F., López, C., Pennington, D. J., & Celada, A. (2003) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00228.2003 · Cited by 109
Akakpo, J. Y., Ramachandran, A., Duan, L., Schaich, M. A., Jaeschke, M. W., Freudenthal, B. D., Ding, W.-X., Rumack, B. H., & Jaeschke, H. (2019) · Toxicological Sciences · doi:10.1093/toxsci/kfz077 · Cited by 105
Subedi, L., Venkatesan, R., & Kim, S. Y. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18071423 · Cited by 109
Wong, C. K., Cheung, P. F., Ip, W., & Lam, C. W. K. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0034oc · Cited by 109
MCL-1 as a Buffer for Proapoptotic BCL-2 Family Members during TRAIL-induced Apoptosis
Meng, X. W., Lee, S. H., Dai, H., Loegering, D. A., Yu, C., Flatten, K. S., Schneider, P. A., Dai, N. T., Kumar, S. K., Smith, B. D., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m706110200 · Cited by 108
Biswas, S. C., Shi, Y., Vonsattel, J., Leung, C. L., Troy, C. M., & Greene, L. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.3524-06.2007 · Cited by 109
Assi, K., Pillai, R., Gómez‐Muñoz, A., Owen, D., & Salh, B. S. (2006) · Immunology · doi:10.1111/j.1365-2567.2006.02349.x · Cited by 108
Ryu, J., & Chun, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601804200 · Cited by 108
Tfelt‐Hansen, J., Macleod, J., Chattopadhyay, N., Yano, S., Quinn, S., Ren, X., Terwilliger, E. F., Schwarz, P., & Brown, E. M. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00489.2002 · Cited by 108
Stress-Activated Protein Kinases Are Involved in Coxsackievirus B3 Viral Progeny Release
Si, X., Luo, H., Morgan, A. J., Zhang, J., Wong, J. T., Ji, Y., Esfandiarei, M., Gao, G., Cheung, C., & McManus, B. M. (2005) · Journal of Virology · doi:10.1128/jvi.79.22.13875-13881.2005 · Cited by 106
Li, J. J., Wang, W., Baines, K. J., Bowden, N. A., Hansbro, P. M., Gibson, P. G., Kumar, R. K., Foster, P. S., & Yang, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001039 · Cited by 107
JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression
Zhao, X., Guo, Y., Jiang, C., Chang, Q., Zhang, S., Luo, T., Zhang, B., Jia, X., Hung, M., Dong, C., et al. (2017) · Nature Medicine · doi:10.1038/nm.4260 · Cited by 106
Mitogen-activated protein kinases as therapeutic targets for asthma
Khorasanizadeh, M., Eskian, M., Gelfand, E. W., & Rezaei, N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.024 · Cited by 107
Luteolin sensitizes tumor necrosis factor-α-induced apoptosis in human tumor cells
Shi, R., Ong, C. N., & Shen, H. (2004) · Oncogene · doi:10.1038/sj.onc.1208046 · Cited by 108
Curran, B. P., Murray, H. J., & O'Connor, J. J. (2003) · Neuroscience · doi:10.1016/s0306-4522(02)00941-7 · Cited by 107
Baranova, I. N., Bocharov, A. V., Vishnyakova, T. G., Kurlander, R. J., Chen, Z., Fu, D., Arias, I. M., Csákó, G., Patterson, A. P., & Eggerman, T. L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.007526 · Cited by 110
Role of MAPKs in platinum-induced neuronal apoptosis
Scuteri, A., Galimberti, A., Maggioni, D., Ravasi, M., Pasini, S., Nicolini, G., Bossi, M., Miloso, M., Cavaletti, G., & Tredici, G. (2009) · NeuroToxicology · doi:10.1016/j.neuro.2009.01.003 · Cited by 106
Geisler, F., Algül, H., Paxian, S. A., & Schmid, R. M. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.03.033 · Cited by 104
Zhou, Q., Wang, M., Du, Y., Zhang, W., Bai, M., Zhang, Z., Li, Z., & Miao, J. (2015) · Annals of Neurology · doi:10.1002/ana.24361 · Cited by 105
Chan, Y.-L., Chang, T.-H., Liao, C., & Lin, Y. (2008) · Journal of Virology · doi:10.1128/jvi.00438-08 · Cited by 105
Nardo, D. D., Nardo, C. M. D., Nguyen, T. U., Hamilton, J. A., & Scholz, G. M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901031 · Cited by 106
Mitogen‐activated protein kinases and asthma
Pelaia, G., Cuda, G., Vatrella, A., Gallelli, L., Caraglia, M., Marra, M., Abbruzzese, A., Caputi, M., Maselli, R., Costanzo, F. S., et al. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20169 · Cited by 105
Cao, J., Semenova, M. M., Solovyan, V. T., Han, J., Coffey, E. T., & Courtney, M. J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402353200 · Cited by 105
Zhong, W., Zhu, H., Sheng, F., Tian, Y., Zhou, J., Chen, Y., Li, S., & Lin, J. (2014) · Autophagy · doi:10.4161/auto.28789 · Cited by 104
Deng, L., Shoji, I., Ogawa, W., Kaneda, S., Soga, T., Jiang, D., Ide, Y.-H., & Hotta, H. (2011) · Journal of Virology · doi:10.1128/jvi.00146-11 · Cited by 107
Chen, H., Sharma, B. B., Yu, L., Zuberi, R. I., Weng, I., Kawakami, Y., Kawakami, T., Hsu, D. K., & Liu, F. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.4991 · Cited by 104
Noncanonical Wnt‐4 signaling and EAF2 are required for eye development in Xenopus laevis
Maurus, D., Héligon, C., Bürger-Schwärzler, A., Brändli, A. W., & Kühl, M. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600603 · Cited by 104
JNK and p38 MAP kinases in CD4+ and CD8+ T cells
Rincón, M., & Pedraza‐Alva, G. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00019.x · Cited by 104
Lipin-2 Reduces Proinflammatory Signaling Induced by Saturated Fatty Acids in Macrophages
Valdearcos, M., Esquinas, E., Meana, C., Peña, L., Gil‐de‐Gómez, L., Balsinde, J., & Balboa, M. A. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.342915 · Cited by 102
Inhibitors of c-Jun N-Terminal Kinases: An Update
Koch, P., Gehringer, M., & Laufer, S. (2014) · Journal of Medicinal Chemistry · doi:10.1021/jm501212r · Cited by 103
JUN is a key transcriptional regulator of the unfolded protein response in acute myeloid leukemia
Zhou, C., Martı́nez, E., Marcantonio, D. D., Solanki-Patel, N., Aghayev, T., Peri, S., Ferraro, F., Skórski, T., Scholl, C., Fröhling, S., et al. (2016) · Leukemia · doi:10.1038/leu.2016.329 · Cited by 105
Gliadin Fragments Induce Phenotypic and Functional Maturation of Human Dendritic Cells
Palová-Jelínková, L., Rožková, D., Pecharová, B., Bártová, J., Šedivá, A., Tlaskalová‐Hogenová, H., Špíšek, R., & Tučková, L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.10.7038 · Cited by 103
Wnt‐3a regulates chondrocyte differentiation via c‐Jun/AP‐1 pathway
Hwang, S., Yu, S., Lee, S.-W., & Chun, J. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.07.067 · Cited by 103
Involvement of ROS in chlorogenic acid-induced apoptosis of Bcr-Abl+ CML cells
Rakshit, S., Mandal, L., Pal, B. C., Bagchi, J., Biswas, N., Chaudhuri, J., Chowdhury, A. A., Manna, A., Chaudhuri, U., Konar, A., et al. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.08.013 · Cited by 106
Meller, R., Cameron, J. A., Torrey, D. J., Clayton, C. E., Ordonez, A. N., Henshall, D. C., Minami, M., Schindler, C. K., Saugstad, J. A., & Simon, R. P. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m512138200 · Cited by 104
Oncogenic and Anti-apoptotic Activity of NF-κB in Human Thyroid Carcinomas
Pacifico, F., Mauro, C., Barone, C., Crescenzi, E., Mellone, S., Monaco, M., Chiappetta, G., Terrazzano, G., Liguoro, D., Vito, P., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403492200 · Cited by 102
Bharti, A. C., Takada, Y., Shishodia, S., & Aggarwal, B. B. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m308062200 · Cited by 104
Uitdehaag, J. C. M., Verkaar, F., Alwan, H. A. J., de Man, J., Buijsman, R. C., & Zaman, G. J. R. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.01859.x · Cited by 103
Wu, H., Kong, L., Tan, Y., Epstein, P. N., Zeng, J., Gu, J., Liang, G., Kong, M., Chen, X., Miao, L., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-3958-8 · Cited by 102
Kesarwani, M., Kincaid, Z., Gomaa, A. R., Huber, E., Rohrabaugh, S., Siddiqui, Z., Bouso, M. F., Latif, T., Xu, M., Komurov, K., et al. (2017) · Nature Medicine · doi:10.1038/nm.4310 · Cited by 98
Kim, H. J., Chakravarti, N., Oridate, N., Choe, C., Claret, F.-X., & Lotan, R. (2005) · Oncogene · doi:10.1038/sj.onc.1209303 · Cited by 101
Mitogen-Activated Protein Kinase Phosphatase-1 Is Required for Cisplatin Resistance
Wang, Z., Xu, J., Zhou, J., Liu, Y., & Wu, G. S. (2006) · Cancer Research · doi:10.1158/0008-5472.can-06-1280 · Cited by 101
The lipolysis pathway sustains normal and transformed stem cells in adult Drosophila
Singh, S. R., Zeng, K. X., Zhao, J., Liu, Y., Hou, G., Liu, H., & Hou, X. S. (2016) · Nature · doi:10.1038/nature19788 · Cited by 96
Diverse Roles for MAPK Signaling in Circadian Clocks
Goldsmith, C. S., & Bell‐Pedersen, D. (2013) · Advances in genetics · doi:10.1016/b978-0-12-407703-4.00001-3 · Cited by 104
Purinergic signaling induces thrombospondin-1 expression in astrocytes
Tran, M. D., & Neary, J. T. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0603146103 · Cited by 100
Lee, J. Y., Maeng, S., Kang, S. R., Choi, H. Y., Oh, T. H., Ju, B. G., & Yune, T. Y. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2013.3146 · Cited by 100
Kawaida, R., Ohtsuka, T., Okutsu, J., Takahashi, T., Kadono, Y., Oda, H., Hikita, A., Nakamura, K., Tanaka, S., & Furukawa, H. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021321 · Cited by 99
Toll-Like Receptor (TLR)2 and TLR4 Agonists Regulate CCR Expression in Human Monocytic Cells
Parker, L. C., Whyte, M. K. B., Vogel, S. N., Dower, S., & Sabroe, I. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.8.4977 · Cited by 99
Lee, C., Lin, W., Lin, C., Luo, S., Wang, J., Pouysségur, J., & Yang, C. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20549 · Cited by 99
Anti-inflammatory phenanthrene derivatives from stems of Dendrobium denneanum
Lin, Y., Wang, F., Yang, L., Chun, Z., Bao, J., & Zhang, G. (2013) · Phytochemistry · doi:10.1016/j.phytochem.2013.08.008 · Cited by 99
Guijas, C., Pérez-Chacón, G., Astudillo, A. M., Rubio, J. M., Gil‐de‐Gómez, L., Balboa, M. A., & Balsinde, J. (2012) · Journal of Lipid Research · doi:10.1194/jlr.m028423 · Cited by 99
Janes, K. A., Albeck, J. G., Peng, L., Sorger, P. K., Lauffenburger, D. A., & Yaffe, M. B. (2003) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m300045-mcp200 · Cited by 99
Mondal, S., Mandal, C., Sangwan, R. S., Chandra, S., & Mandal, C. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-239 · Cited by 99
Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors
Abrahamsson, T., Chou, C. Y. C., Li, S. S. Y., Mancino, A. S., Costa, R. P., Brock, J. A., Nuro, E., Buchanan, K. A., Elgar, D., Blackman, A. V., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.030 · Cited by 102
Involvement of c‐Jun N‐terminal kinase in amyloid precursor protein‐mediated neuronal cell death
Hashimoto, Y., Tsuji, O., Niikura, T., Yamagishi, Y., Ishizaka, M., Kawasumi, M., Chiba, T., Kanekura, K., Yamada, M., Tsukamoto, E., et al. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01585.x · Cited by 99
The role of JNK in prostate cancer progression and therapeutic strategies
Xu, R., & Hu, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109679 · Cited by 102
Inhibition of Wnt-1 Signaling Induces Apoptosis in β-Catenin-Deficient Mesothelioma Cells
You, L., He, B., Uematsu, K., Xu, Z., Mazières, J., Lee, A. Y., McCormick, F. P., & Jablons, D. M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0115 · Cited by 98
Aono, S., & Hirai, Y. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.08.012 · Cited by 95
Dai, Y., Pei, X., Rahmani, M., Conrad, D. H., Dent, P., & Grant, S. (2003) · Blood · doi:10.1182/blood-2003-09-3037 · Cited by 97
Holzberg, D., Knight, C. G., Dittrich‐Breiholz, O., Schneider, H., Dörrie, A., Hoffmann, E., Resch, K., & Kracht, M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304058200 · Cited by 97
Yu, C., Rahmani, M., Dai, Y., Conrad, D. H., Krystal, G. W., Dent, P., & Grant, S. (2003) · PubMed · Cited by 97
Aguado, J., Chaggar, H. K., Gómez‐Inclán, C., Shaker, M. R., Leeson, H. C., Mackay‐Sim, A., & Wolvetang, E. J. (2021) · Aging Cell · doi:10.1111/acel.13468 · Cited by 92
Bas, E., Dinh, C. T., Garnham, C., Polák, M., & Water, T. R. V. D. (2012) · The Anatomical Record · doi:10.1002/ar.22574 · Cited by 98
CCL3 promotes angiogenesis by dysregulation of miR-374b/ VEGF-A axis in human osteosarcoma cells
Liao, Y., Tsai, H., Chou, P.-Y., Wang, S., Chen, H., Lin, Y., Chiang, I., Chang, T.-M., Hsu, S.-K., Chou, M., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.6708 · Cited by 96
Oltmanns, U., Issa, R., Sukkar, M. B., John, M., & Chung, K. F. (2003) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705345 · Cited by 96
Ma, C., Ying, C., Yuan, Z., Song, B., Li, D., Liu, Y., Lai, B., Li, W., Chen, R., Ching, Y.-P., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608694200 · Cited by 96
Dowdy, S. C., Mariani, A., & Janknecht, R. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307202200 · Cited by 97
Watanabe, H., Shimizu, T., Nishihira, J., Abe, R., Nakayama, T., Taniguchi, M., Sabe, H., Ishibashi, T., & Shimizu, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m303650200 · Cited by 96
Shi, Y., Cosentino, F., Camici, G. G., Akhmedov, A., Vanhoutte, P. M., Tanner, F. C., & Lüscher, T. F. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.229260 · Cited by 99
Rahmani, M., Yu, C., Reese, E., Ahmed, W. B., Hirsch, K. G., Dent, P., & Grant, S. (2003) · Oncogene · doi:10.1038/sj.onc.1206646 · Cited by 96
Nel, A. E., & Slaughter, N. (2002) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2002.124965 · Cited by 96
Baritaud, M., Cabon, L., Delavallée, L., Galán‐Malo, P., Me, G., Brunelle-Navas, M.-N., & Susín, S. A. (2012) · Cell Death and Disease · doi:10.1038/cddis.2012.120 · Cited by 98
De, S. K., Stebbins, J. L., Chen, L., Riel-Mehan, M. M., Machleidt, T., Dahl, R. S., Yuan, H., Emdadi, A., Barile, E., Chen, V., et al. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm801503n · Cited by 95
The mitogen‐activated protein kinase signaling pathways: role in megakaryocyte differentiation
Séverin, S., Ghevaert, C., & Mazharian, A. (2009) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2009.03658.x · Cited by 105
Berberine-induced LDLR up-regulation involves JNK pathway
Lee, S., Lim, H., Park, J., Lee, K., Jang, Y., & Park, H. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.08.060 · Cited by 94
Metadata
- Authors
- Bennett, B. L., Sasaki, D. T., Murray, B. W., O'Leary, E. C., Sakata, S. T., Xu, W., Leisten, J. C., Motiwala, A., Pierce, S., Satoh, Y., Bhagwat, S. S., Manning, A. M., & Anderson, D. W.
- Affiliations
- Signal Research Division, Celgene Corporation, 5555 Oberlin Drive, San Diego, CA 92121
- Yale University (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2001-11-20
- Volume
- 98
- Issue
- 24
- Pages
- 13681-13686
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC61101
- OpenAlex
- W2096931514
- Cited by
- 2,558
- References
- 46
- Citations by year
- 2026: 40 · 2025: 49 · 2024: 77 · 2023: 66 · 2022: 51 · 2021: 69 · 2020: 71 · 2019: 52 · 2018: 60 · 2017: 91 · 2016: 97 · 2015: 80 · 2014: 100 · 2013: 107 · 2012: 132
- FWCI
- 47.43
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › NF-κB Signaling Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- SP600125, Jun N-terminal kinase, ATP-competitive kinase inhibitors, c-Jun phosphorylation, inflammatory gene expression, cyclooxygenase-2, TNF-α, lipopolysaccharide, CD4+ T cell activation, apoptosis, thymocytes, inflammatory diseases, cancer
- MeSH terms
- Adenosine Triphosphate, Animals, Anthracenes, Anthraquinones, Binding, Competitive, Cell Differentiation, Cells, Cultured, Enzyme Inhibitors, Female, Humans, Lymphocyte Activation, Mice, Inbred C57BL, Monocytes, Pyrazoles, Structure-Activity Relationship, Tumor Necrosis Factor-alpha, Molecular Structure, CD4-Positive T-Lymphocytes, Gene Expression, Cytokines, Jurkat Cells, Mitogen-Activated Protein Kinases, Pyrazolones, Protein Kinase Inhibitors, JNK Mitogen-Activated Protein Kinases, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
