Analysis of Gene Diversity in Subdivided Populations
Open accessAbstract
A method is presented by which the gene diversity (heterozygosity) of a subdivided population can be analyzed into its components, i.e., the gene diversities within and between subpopulations. This method is applicable to any population without regard to the number of alleles per locus, the pattern of evolutionary forces such as mutation, selection, and migration, and the reproductive method of the organism used. Measures of the absolute and relative magnitudes of gene differentiation among subpopulations are also proposed.
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The variance in group means was computed without using Bessel's correction, as shown by Weaver (51) to be the correct formula for Nei's FST (52).
“We note that we computed the variance in group means without using Bessel’s correction, as shown by Weaver (51) to be the correct formula for Nei’s FST (52).”
From Heritability within groups is uninformative about differences among groups: Cases from behavioral, evolutionary, and statistical genetics (2024) · cites this paper as [52]
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- [6]Nei, M. (1973) in Genetics of Population Structure, ed. Morton, N. É. (Univ. of Hawaii, Honolulu), in press.
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- Authors
- Nei, M.
- Affiliations
- Center for Demographic and Population Genetics, University of Texas at Houston, Tex. 77025
- Corresponding author
- Nei, Masatoshi
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1973-12
- Volume
- 70
- Issue
- 12
- Pages
- 3321-3323
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC427228
- OpenAlex
- W1988182864
- Cited by
- 8,885
- References
- 0
- Citations by year
- 2026: 138 · 2025: 152 · 2024: 222 · 2023: 240 · 2022: 277 · 2021: 341 · 2020: 335 · 2019: 345 · 2018: 276 · 2017: 332 · 2016: 341 · 2015: 362 · 2014: 394 · 2013: 386 · 2012: 393
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service (GM 20293)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic diversity and population structure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Evolution and Genetic Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Forensic and Genetic Research
- Keywords
- genetic diversity, heterozygosity, subpopulations, population genetics, gene differentiation, subpopulation differentiation, allele frequency, genetic mutations, selection, migration, reproductive methods
- MeSH terms
- Alleles, Gene Frequency, Genetics, Population, Heterozygote, Models, Biological, Genetic Variation
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