The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Detection of Mutagenic Activity in Cigarette Smoke Condensates
Open accessAbstract
The Salmonella typhimurium microsomal test system for mutagenic activity was successfully used to detect the presence of mutagenic compounds in the smoke condensates of several types of cigarettes. The condensates were shown to contain compounds which could cause frameshift mutations when activated by microsomal enzymes. An analysis of fractions of smoke condensate revealed that the detected mutagenic activity was distributed in several of the fractions. Most of the activity of the whole condensate was in basic fractions and in a weakly acidic fraction. Condensates from cigarettes treated with magnesium nitrate differed from other condensates in two respects. They contained frameshift mutagens which did not require microsomal activation and mutagens which could cause base-pair substitution mutations. Although the detection system usually employs rat liver microsomal preparations, a rat lung microsomal preparation was also found to be capable of converting smoke condensates and known chemical carcinogens into mutagenic forms.
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Self-citationAn Improved Bacterial Test System for the Detection and Classification of Mutagens and Carcinogens
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Self-citationChemical composition of tobacco and tobacco smoke
Stedman, R. L. (1968) · Chemical Reviews · doi:10.1021/cr60252a002 · Cited by 738
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Self-citationPolychlorinated Biphenyls: A New Type of Inducer of Cytochrome P-448 in the Liver
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Epoxides of Carcinogenic Polycyclic Hydrocarbons Are Frameshift Mutagens
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Self-citationCzygan, P., Greim, H. A., Garro, A. J., Hutterer, F., Schaffner, F., Pópper, H., Rosenthal, O., & Cooper, D. Y. (1973) · PubMed · Cited by 211
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Cited by
Detection of carcinogens as mutagens in the Salmonella/microsome test: assay of 300 chemicals.
McCann, J., Choi, E., Yamasaki, E., & Ames, B. N. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.12.5135 · Cited by 3,323
Self-citationDetection of carcinogens as mutagens: bacterial tester strains with R factor plasmids.
McCann, J., Spingarn, N. E., Kobori, J., & Ames, B. N. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.3.979 · Cited by 1,016
Self-citationShort-term tests for carcinogens and mutagens
Hollstein, M., McCann, J., Angelosanto, F. A., & Nichols, W. W. (1979) · Mutation Research/Reviews in Genetic Toxicology · doi:10.1016/0165-1110(79)90014-9 · Cited by 685
Identifying Environmental Chemicals Causing Mutations and Cancer
Ames, B. N. (1979) · Science · doi:10.1126/science.373122 · Cited by 586
Self-citationHair dyes are mutagenic: identification of a variety of mutagenic ingredients.
Ames, B. N., Kammen, H. O., & Yamasaki, E. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.6.2423 · Cited by 473
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Metadata
- Authors
- Kier, L. D., Yamasaki, E., & Ames, B. N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1974-10
- Volume
- 71
- Issue
- 10
- Pages
- 4159-4163
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1965433424
- Cited by
- 282
- References
- 12
- FWCI
- 8.11
- Type
- journal article
- Language
- en
- Open access
- green
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- Kier, L. D., Yamasaki, E., & Ames, B. N. (1974). Detection of Mutagenic Activity in Cigarette Smoke Condensates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.71.10.4159
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