The DOI matches its Crossref record.
Human lymphocyte production of corticotropin and endorphin-like substances: association with leukocyte interferon.
Open accessAbstract
Human leukocyte interferon (hIFN-alpha) preparations contain immunologically and biologically recognizable endorphin and corticotropin-like (ACTH-like) activities. The ACTH bioactivity was demonstrable only after pepsin or acid treatment. Highly purified hIFN-alpha was composed of two molecular species of interferon (18,500 and 23,000 daltons). Endorphin activity was associated with both of these molecules. Pepsin treatment of the 23,000-dalton but not the 18,500-dalton hIFN-alpha generated ACTH activity. In acid, the 23,000-dalton hIFN-alpha broke down into the 18,500-dalton form and ACTH (4500 daltons). The ACTH derived from hIFN-alpha by pepsin digestion comigrated with a purified ACTH standard in NaDodSO4/polyacrylamide gel electrophoresis. hIFN-alpha-producing lymphocytes showed positive immunofluorescence after staining with highly specific antisera to ACTH alpha-(1-13) and gamma-endorphin. Essentially 100% of the human peripheral lymphocytes were capable of producing both ACTH and gamma-endorphin-related substances, presumably associated with hIFN-alpha. These results strongly suggest a circuit between the immune and neuroendocrine systems which involves neuroendocrine hormone-like substances, some of which are associated with hIFN-alpha
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Regulation of the Hypothalamic-Pituitary-Adrenal Axis by Cytokines: Actions and Mechanisms of Action
TURNBULL, A. V., & RIVIER, C. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.1 · Cited by 1,297
Neuroimmune Interactions: From the Brain to the Immune System and Vice Versa
Dantzer, R. (2018) · Physiological Reviews · doi:10.1152/physrev.00039.2016 · Cited by 1,073
Immune modulation of the hypothalamic-pituitary-adrenal (HPA) axis during viral infection
Silverman, M. N., Pearce, B. D., Biron, C. A., & Miller, A. H. (2005) · Viral Immunology · doi:10.1089/vim.2005.18.41 · Cited by 506
Interleukin-1 beta: a putative mediator of HPA axis hyperactivity in major depression?
(1993) · American Journal of Psychiatry · doi:10.1176/ajp.150.8.1189 · Cited by 364
Suicide associated with alfa-interferon therapy for chronic viral hepatitis
Janssen, H. L. A., Brouwer, J. T., van der Mast, R. C., & Schalm, S. W. (1994) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80402-7 · Cited by 229
Conceptual development of the immune system as a sixth sense
Blalock, J. E., & Smith, E. M. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2006.09.004 · Cited by 153
Self-citationNeuroendocrine-immune interactions and responses to exercise
Fragala, M. S., Kraemer, W. J., Denegar, C. R., Maresh, C. M., Mastro, A. M., & Volek, J. S. (2011) · Sports Medicine · doi:10.2165/11590430-000000000-00000 · Cited by 145
Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients
Fetissov, S. O., Hallman, J., Oreland, L., af Klinteberg, B., Grenbäck, E., Hulting, A.-L., & Hökfelt, T. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.222658699 · Cited by 140
Central nervous system influences on lymphocyte migration
Ottaway, C. A., & Husband, A. J. (1992) · Brain, Behavior, and Immunity · doi:10.1016/0889-1591(92)90011-c · Cited by 125
Neuroimmunoregulation and natural immunity
Berczi, I., Chow, D. A., & Sabbadini, E. R. (1998) · Domestic Animal Endocrinology · doi:10.1016/s0739-7240(98)00015-0 · Cited by 43
Felten, D. L. (2000) · Progress in brain research · doi:10.1016/s0079-6123(08)62152-4 · Cited by 39
Metadata
- Authors
- Smith, E. M., & Blalock, J. E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1981-12
- Volume
- 78
- Issue
- 12
- Pages
- 7530-7534
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2004652754
- Cited by
- 356
- References
- 0
- FWCI
- 3.90
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
