Suicide associated with alfa-interferon therapy for chronic viral hepatitis
Abstract
We report on two attempted suicides and one successful suicide during or shortly after alfa-interferon therapy for chronic viral hepatitis. While on therapy, all three patients developed a psychiatric disorder leading to their suicidal behavior. In a survey of 15 European hospitals, three cases of attempted and two of successful suicide during alfa-interferon therapy for chronic viral hepatitis, were additionally reported. None of the patients had a psychiatric history. Alfa-interferon is known to lead to neuropsychiatric symptoms, and our observations strongly suggest that these mental disorders could lead to suicidal behavior. Therefore it is important that physicians, patients and their families are informed about the potential risk of the emotional and psychiatric disturbances that can occur during alfa-interferon therapy.
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Specific symptoms induced by IFNα administration include anxiety, pain, depressed mood, anhedonia, fatigue, cognitive impairment, sleep disturbance, anger, hostility, loss of appetite, and suicidal ideation.
“Specific symptoms induced by IFNα administration include anxiety, pain, depressed mood, anhedonia, fatigue, cognitive impairment, sleep disturbance, anger, hostility, loss of appetite, and suicidal ideation”
From From stress to inflammation and major depressive disorder: A social signal transduction theory of depression. (2014) · cites this paper as Janssen, Brouwer, van der Mast, & Schalm, 1994
IFN-α can induce depressed mood, fatigue, sleep disturbance, loss of appetite, pain, anxiety, anhedonia, anger, hostility, cognitive impairment, and suicidal ideation.
“Studies of patients receiving this treatment have shown that IFN-α can induce symptoms of depressed mood, fatigue, sleep disturbance, loss of appetite, pain, anxiety, anhedonia, anger, hostility, cognitive impairment, and suicidal ideation (Capuron et al., 2002; Janssen et al., 1994; Lotrich et al., 2007).”
From The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation. (2018) · cites this paper as Janssen et al., 1994
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- Authors
- Janssen, H. L. A., Brouwer, J. T., van der Mast, R. C., & Schalm, S. W.
- Affiliations
- Academisch Ziekenhuis Rotterdam (NL)
- Corresponding author
- Schalm, Solko W.
- Venue
- Journal of Hepatology
- Publisher
- Elsevier BV
- Published
- 1994-01
- Volume
- 21
- Issue
- 2
- Pages
- 241-243
- ISSN
- 0168-8278 (ISSN-L)
- OpenAlex
- W2158811343
- Cited by
- 229
- References
- 11
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 2 · 2023: 4 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 4 · 2018: 2 · 2017: 4 · 2016: 5 · 2015: 10 · 2014: 6 · 2013: 5 · 2012: 5
- FWCI
- 6.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- suicide, interferon-alpha, chronic viral hepatitis, psychiatric adverse effects, neuropsychiatric symptoms, suicidal behavior, drug-induced psychiatric disorders, hepatitis C treatment
- MeSH terms
- Adult, Chronic Disease, Female, Hepatitis, Viral, Human, Humans, Male, Middle Aged, Suicide, Attempted, Interferon-alpha
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