Autoantibodies against α-MSH, ACTH, and LHRH in anorexia and bulimia nervosa patients
Open accessAbstract
The hypothalamic arcuate nucleus is involved in the control of energy intake and expenditure and may participate in the pathogenesis of eating disorders such as anorexia nervosa (AN) and bulimia nervosa (BN). Two systems are of particular interest in this respect, synthesizing alpha-melanocyte-stimulating hormone (alpha-MSH) and synthesizing neuropeptide Y, respectively. We report here that 42 of 57 (74%) AN andor BN patients studied had in their plasma Abs that bind to melanotropes andor corticotropes in the rat pituitary. Among these sera, 8 were found to bind selectively to alpha-MSH-positive neurons and their hypothalamic and extrahypothalamic projections as revealed with immunostaining on rat brain sections. Adsorption of these sera with alpha-MSH peptide abolished this immunostaining. In the pituitary, the immunostaining was blocked by adsorption with alpha-MSH or adrenocorticotropic hormone. Additionally, 3 ANBN sera bound to luteinizing hormone-releasing hormone (LHRH)-positive terminals in the rat median eminence, but only 2 of them were adsorbed with LHRH. In the control subjects, 2 of 13 sera (16%) displayed similar to ANBN staining. These data provide evidence that a significant subpopulation of ANBN patients have autoantibodies that bind to alpha-MSH or adrenocorticotropic hormone, a finding pointing also to involvement of the stress axis. It remains to be established whether these Abs interfere with normal signal transduction in the brain melanocortin circuitryLHRH system andor in other central and peripheral sites relevant to food intake regulation, to what extent such effects are related to andor could be involved in the pathophysiology or clinical presentation of ANBN, and to what extent increased stress is an important factor for production of these autoantibodies.
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Autoantibodies directed against α-MSH have been discovered in both healthy individuals and subjects with eating disorders.
“Autoantibodies directed against the peptide α-Melanocyte-stimulating hormone (α-MSH), which is involved in appetite control, have been discovered in both healthy individuals and in subjects with eating disorders (Fetissov et al., 2002;Fetissov et al., 2008).”
From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Fetissov et al., 2002
A subgroup of patients with anorexia nervosa and bulimia nervosa had autoantibodies that bind to α-melanocyte-stimulating hormone, and the circulating level of these autoantibodies was correlated with psychological traits of eating disorders.
“Fetissov and colleagues [45,46] revealed that a subgroup of patients with AN and BN had autoantibodies that bind to the α-melanocyte-stimulating hormone (MSH), and the circulating level of these autoantibodies was correlated with the psychological traits of eating disorders.”
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Neuropeptide Autoantibodies Assay
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Looking at neurotransmitters in the microscope
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The putative role of neuropeptide autoantibodies in anorexia nervosa
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Bacterial Protein Mimetic of Peptide Hormone as a New Class of Protein- based Drugs
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Anorexia nervosa: towards a neurobiologically based therapy
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Hypothalamitis: A Novel Autoimmune Endocrine Disease. A Literature Review and Case Report
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The Hypothalamic–Pituitary Axis and Autoantibody Related Disorders
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Repeated gastric distension alters food intake and neuroendocrine profiles in rats
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Anorexia nervosa, autoimmunity and the hygiene hypothesis
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Anti-Melanocortin-4 Receptor Autoantibodies in Obesity
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Evidence for hypothalamic dysregulation in mouse models of anorexia as well as in humans
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CMV-associated encephalitis and antineuronal autoantibodies - a case report
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Conséquences digestives de l’anorexie mentale
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Nesfatin-1 in the neurochemistry of eating disorders
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- Authors
- Fetissov, S. O., Hallman, J., Oreland, L., af Klinteberg, B., Grenbäck, E., Hulting, A.-L., & Hökfelt, T.
- Affiliations
- Departments of Neuroscience and Endocrinology, Karolinska Institute, SE-171 77 Stockholm, Sweden; Department of Neuroscience, Biomedical Center, SE-751 24 Uppsala, Sweden; and Department of Psychology, Stockholm University, SE-106 91 Stockholm, Sweden
- Uppsala University (SE)
- ORCID
- Hökfelt, Tomas
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2002-12-16
- Volume
- 99
- Issue
- 26
- Pages
- 17155-17160
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC139285
- OpenAlex
- W2028553430
- Cited by
- 140
- References
- 39
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 5 · 2019: 10 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 5 · 2014: 8 · 2013: 5 · 2012: 3
- FWCI
- 9.28
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- autoantibodies, alpha-melanocyte-stimulating hormone, ACTH, gonadotropin-releasing hormone, anorexia nervosa, bulimia nervosa, eating disorders, hypothalamic arcuate nucleus, melanocortin system, neuropeptide Y, stress axis, pituitary gland, median eminence, food intake regulation
- MeSH terms
- Adolescent, Adrenocorticotropic Hormone, Adult, alpha-MSH, Animals, Anorexia, Autoantibodies, Bulimia, Female, Humans, Immunohistochemistry, Gonadotropin-Releasing Hormone, Male, Rats, Sprague-Dawley, Rats
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