Chapter 4 β‐Globin Regulation and Long‐Range Interactions

Capturing Chromosome Conformation

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The Role of Chromatin during Transcription

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Transcriptional activation by recruitment

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Active genes dynamically colocalize to shared sites of ongoing transcription

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Gene regulation by proteins acting nearby and at a distance

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Going the Distance: A Current View of Enhancer Action

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The LIM‐only protein Lmo2 is a bridging molecule assembling an erythroid, DNA‐binding complex which includes the TAL1, E47, GATA‐1 and Ldb1/NLI proteins

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Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions

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Transcriptional Pulsing of a Developmental Gene

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CTCF mediates long-range chromatin looping and local histone modification in the β-globin locus

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Protein Dynamics: Implications for Nuclear Architecture and Gene Expression

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Long-range chromatin regulatory interactions in vivo

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Interchromosomal Interactions and Olfactory Receptor Choice

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Diffusion-driven mechanisms of protein translocation on nucleic acids. 3. The Escherichia coli lac repressor-operator interaction: kinetic measurements and conclusions

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The β-globin nuclear compartment in development and erythroid differentiation

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The concept of self-organization in cellular architecture

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Proximity among Distant Regulatory Elements at the β-Globin Locus Requires GATA-1 and FOG-1

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Looping versus linking: toward a model for long-distance gene activationPreprint

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Transcription complex stability and chromatin dynamics in vivo

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A deletion of the human beta-globin locus activation region causes a major alteration in chromatin structure and replication across the entire beta-globin locus.Preprint

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Locus control regions

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A transcription reinitiation intermediate that is stabilized by activator

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Evidence for a locus activation region: the formation of developmentally stable hypersensitive sites in globin-expressing hybrids

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The depletion attraction: an underappreciated force driving cellular organization

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A developmentally stable chromatin structure in the human beta-globin gene cluster.

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CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation

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The active spatial organization of the β-<i>globin</i> locus requires the transcription factor EKLF

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Spatial organization of gene expression: the active chromatin hub

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DNA looping between sites for transcriptional activation: self-association of DNA-bound Sp1.Preprint

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Gene loops juxtapose promoters and terminators in yeast

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Acetylation and modulation of erythroid Krüppel-like factor (EKLF) activity by interaction with histone acetyltransferases

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Intergenic Transcription and Developmental Remodeling of Chromatin Subdomains in the Human β-globin Locus

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Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.Preprint

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The locus control region is required for association of the murine β-globin locus with engaged transcription factories during erythroid maturationPreprint

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Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locusPreprint

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Visualization of looping involving the immunoglobulin heavy-chain locus in developing B cellsPreprint

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Human γ-globin genes silenced independently of other genes in the β-globin locus

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Distant liaisons: long-range enhancer–promoter interactions in Drosophila

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The β-Globin LCR Is Not Necessary for an Open Chromatin Structure or Developmentally Regulated Transcription of the Native Mouse β-Globin Locus

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The beta -globin locus control region (LCR) functions primarily by enhancing the transition from transcription initiation to elongation.Preprint

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Site-Specific Acetylation by p300 or CREB Binding Protein Regulates Erythroid Krüppel-Like Factor Transcriptional Activity via Its Interaction with the SWI-SNF Complex

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Effects of altered gene order or orientation of the locus control region on human β-globin gene expression in mice

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Entropy-Driven Genome Organization

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Multiple interactions between regulatory regions are required to stabilize an active chromatin hub

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Distinct Mechanisms Control RNA Polymerase II Recruitment to a Tissue-Specific Locus Control Region and a Downstream Promoter

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A Mechanism for Coordinating Chromatin Modification and Preinitiation Complex Assembly

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Analysis of Mice Containing a Targeted Deletion of β-Globin Locus Control Region 5′ Hypersensitive Site 3

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The Locus Control Region Is Necessary for Gene Expression in the Human β-Globin Locus but Not the Maintenance of an Open Chromatin Structure in Erythroid Cells

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The human β-globin gene contains a downstream developmental specific enhancer

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A Complex Chromatin Landscape Revealed by Patterns of Nuclease Sensitivity and Histone Modification within the Mouse β-Globin Locus

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Reversible contraction by looping of the Tcra and Tcrb loci in rearranging thymocytes

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