Cited by 629Alzheimer's disease research and treatmentsUbiquitin and proteasome pathwaysDementia and Cognitive Impairment Research

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Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

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Perry, G, Friedman, R, Shaw, G, Chau, V·1987·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.84.9.3033PMC PMC304795

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Abstract

Neurofibrillary tangles (NFT) and neurites associated with senile plaques (SP) in Alzheimer disease-affected brain tissues were specifically immunostained with affinity-purified antibody preparations directed against ubiquitin. In addition, a class of neurites seen in brain regions containing NFT and SP were also specifically stained. Cross-reactivity of the ubiquitin antisera for tau protein, neurofilament proteins, and high molecular weight microtubule-associated proteins (MAPs) were ruled out by (i) the inability of the ubiquitin antisera to stain these proteins in immunoblotting experiments and (ii) the inability of tau, neurofilament, and MAP preparations, when preincubated with the ubiquitin antisera, to inhibit the selective neurofibrillar staining observed. Our results are consistent with the suggestion that ubiquitin is covalently associated with the insoluble neurofibrillary material of NFT and SP. We propose that the ubiquitin-mediated degradative pathway may be ineffective in removing these fibrillar structures in Alzheimer disease brain.

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Authors: Perry, G., Friedman, R., Shaw, G., & Chau, V
Affiliations: Case Western Reserve University (US)
ORCID: Perry, G
Shaw, G
Chau, V
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1987-05
Volume: 84
Issue: 9
Pages: 3033-3036
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.84.9.3033
PMC: PMC304795
OpenAlex: W2046720254
Cited by: 623
References: 27
Citations by year: 2026: 6 · 2025: 8 · 2024: 11 · 2023: 13 · 2022: 8 · 2021: 15 · 2020: 17 · 2019: 15 · 2018: 21 · 2017: 11 · 2016: 17 · 2015: 15 · 2014: 5 · 2013: 20 · 2012: 18
FWCI: 33.38
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Aging (AG00795)
National Institute of General Medical Sciences (GM35803)
National Institute of Neurological Disorders and Stroke (NS22695)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ubiquitin and proteasome pathways
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords: ubiquitin, neurofibrillary tangles, amyloid plaques, Alzheimer's disease, neurites, protein degradation, tau protein, neurofilaments, microtubule-associated proteins, immunostaining
MeSH terms: Aged, Alzheimer Disease, Antibodies, Antigen-Antibody Complex, Axons, Brain, Humans, Immunoenzyme Techniques, Neurons, Ubiquitins

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Ubiquitin is detected in neurofibrillary tangles and senile plaque neurites of Alzheimer disease brains.

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