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Micromotion of mammalian cells measured electrically.
Open accessAbstract
Motility is a fundamental property of mammalian cells that normally is observed in tissue culture by time lapse microscopy where resolution is limited by the wavelength of light. This paper examines a powerful electrical technique by which cell motion is quantitatively measured at the nanometer level. In this method, the cells are cultured on small evaporated gold electrodes carrying weak ac currents. A large change in the measured electrical impedance of the electrodes is observed when cells attach and spread on these electrodes. When the impedance is tracked as a function of time, fluctuations are observed that are a direct measure of cell motion. Surprisingly, these fluctuations continue even when the cell layer becomes confluent. By comparing the measured impedance with a theoretical model, it is clear that under these circumstances the average motions of the cell layer of 1 nm can be inferred from the measurements. We refer to this aspect of cell motility as micromotion.
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Cited by
Good, R. B., Gilbane, A. J., Trinder, S. L., Denton, C. P., Coghlan, G., Abraham, D. J., & Holmes, A. M. (2015) · The American Journal of Pathology · doi:10.1016/j.ajpath.2015.03.019 · Cited by 349
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Mizee, M. R., Wooldrik, D., Lakeman, K. A. M., van het Hof, B., Drexhage, J. A. R., Geerts, D., Bugiani, M., Aronica, E., Mebius, R. E., Prat, A., et al. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1338-12.2013 · Cited by 203
Nguyen, T. A., Yin, T.-I., Reyes, D., & Urban, G. A. (2013) · Analytical Chemistry · doi:10.1021/ac402761s · Cited by 189
Human In Vitro Skin Models for Wound Healing and Wound Healing Disorders
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Hildebrandt, C., Büth, H., Cho, S., Impidjati, & Thielecke, H. (2010) · Journal of Biotechnology · doi:10.1016/j.jbiotec.2010.01.007 · Cited by 95
Metadata
- Authors
- Giaever, I., & Keese, C. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-09
- Volume
- 88
- Issue
- 17
- Pages
- 7896-7900
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2038628992
- Cited by
- 828
- References
- 0
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Giaever, I., & Keese, C. R. (1991). Micromotion of mammalian cells measured electrically. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.17.7896
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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