The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.
Open accessAbstract
A wild-type p53 gene under control of the metallothionein MT-1 promoter was stably transfected into human colon tumor-derived cell line EB. Repeated inductions of the metallothionein wild-type p53 gene with zinc chloride results in progressive detachment of wild-type p53 cells grown on culture dishes. Examination at both the light and electron microscopic level revealed that cells expressing wild-type p53 developed morphological features of apoptosis. DNA from both attached and detached cells was degraded into a ladder of nucleosomal-sized fragments. Expression of wild-type p53 inhibited colony formation in soft agar and tumor formation in nude mice. Furthermore, established tumors in nude mice underwent regression if wild-type p53 expression was subsequently induced. Regressing tumors showed histological features of apoptosis. Thus, regression of these tumors was the result of apoptosis occurring in vivo. Apoptosis may be a normal part of the terminal differentiation program of colonic epithelial cells. Our results suggest that wild-type p53 could play a critical role in this process.
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Cited by
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Metadata
- Authors
- Shaw, P., Bovey, R., Tardy, S., Sahli, R., Sordat, B., & Costa, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1992-05-15
- Volume
- 89
- Issue
- 10
- Pages
- 4495-4499
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1977686001
- Cited by
- 848
- References
- 3
- FWCI
- 38.09
- Type
- journal article
- Language
- en
- Open access
- green
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