Cited by 178Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromosomal and Genetic Variations

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The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

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Dorn, R, Krauss, V, Reuter, G, Saumweber, H·1993·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.90.23.11376PMC PMC47985

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Abstract

In Drosophila modifying mutations of position-effect variegation have been successfully used to genetically dissect chromatin components. The enhancer of position-effect variegation E(var)3-93D [formerly E-var(3)3] encodes proteins containing a domain common to the transcriptional regulators tramtrack and the products of the Broad complex. It interacts with a number of chromatin genes that suppress position-effect variegation. Mutations in E(var)3-93D exhibit an imprinting-like effect on the Y chromosome. This effect is transmitted paternally over several generations. Homeotic transformations in E(var)3-93D mutants indicate an involvement of the gene products in regulation of homeotic gene complexes. An antiserum raised against E(var)3-93D protein detects this chromosomal protein in a large subset of sites in polytene chromosomes. Our genetic and molecular data suggest that the proteins of E(var)3-93D are generally involved in establishing and/or maintaining an open chromatin conformation.

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BackgroundInfluential
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BackgroundMethod
MOD(MDG4)-64.2 protein, isoform of MOD(MDG4) loci, directly interacts with the Tweedle protein family of Drosophila melanogaster
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BackgroundInfluential
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Chromatin Structure, Heterochromatin, and Transposable Genetic Elements: Are These Teammates?
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Mutations in the nomad retroelement are modifiers of position-effect variegation in Drosophila melanogaster
Whalen, J. H., O'Grady, M., & Grigliatti, T. A. (2003) · Chromosome Research · doi:10.1023/a:1024900817776 · Cited by 1
“To date at least ¢ve E(var)s have been cloned and seem to encode proteins which are generally involved in transcriptional activation, rather than the establishment of chromatin structure per se (Dorn et al. 1993, Farkas et al. 1994, De Rubertis et al. 1996, Seum et al. 1996, Sinclair et al. 1998b).”
Background
Studies on the Mechanisms of Homolog Pairing and Sister Chromatid Cohesion During Drosophila Male Meiosis
Ma, J. (2007)
EPIGENETICS-EPIDISEASES-EPIDRUGS
Antonova, S. (2013) · Utrecht University Repository (Utrecht University)
Investigation Of X Chromosome Recognition: The Role Of Small Rna In Drosophila Dosage Compensation
Menon, D. U. (2013) · Human Biology
The LAZ3/BCL6 Oncogene Encodes a Sequence-specific Transcriptional Inhibitor: A Novel Function for the BTB/POZ Domain as an Autonomous
Deweindt, C., Albagli, O., Bernardin, F., Dhordain, P., Quief, S., & Leprince, D. (1995)
Identification and characterization of the E(var)3-5 gene in Drosophila melanogaster
Sahasrabhojane, P. V. (2008) · doi:10.33915/etd.4419
“Dorn et al. (1993b) thus suggested that the mutations might be spontaneous in nature.”
BackgroundMethodInfluential
Adaptação de Helicoverpa armigera aos inibidores de peptidase de soja envolve uma alteração no padrão de expressão das serino peptidases e sugere um controle epigenético
Velasquez-Vasconez, P. A. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.11.2021.tde-14022022-143313
New transcriptional roles for the classic Drosophila insulator protein Suppressor of Hairy-wing
Soshnev, A. A. (2012) · doi:10.17077/etd.potlh8sl
“2 isoform have no known phenotype outside of the loss of gypsy insulator function (Dorn et al., 1993; Georgiev and Gerasimova, 1989).”
Background
The essential JIL-1 kinase regulates histone H3 phosphorylation and maintains chromatin structure in Drosophila
Zhang, W. (2004) · doi:10.31274/rtd-180813-2110
Regulation of heterochromatin by a pluripotency-associated long non coding RNA in mouse embryonic stem cells and in oocytes : implications for early embryogenesis
Bernard, L. D. (2021) · theses.fr (ABES) · doi:10.70675/05f4f7dbz61a7z4676za4a0za42de848cbcd
Genome-Wide Identification, Expression and Tissue-Specific Epigenetic Modification Analysis of the Su(var)3-9 SET Gene Family in Soybean
Wang, M., Zhou, W., Zhang, Z., Cao, L., Wang, L., Xie, L., Wu, J., Haoce, X., & Jia, N. (2026) · Biology · doi:10.3390/biology15131085
“The SET domain was first discovered in Drosophila at the C-terminal of three regulatory proteins (Su(var)3-9, E(z), and Trithorax) [2–5].”

Authors: Dorn, R., Krauss, V, Reuter, G., & Saumweber, H.
Affiliations: Martin Luther University Halle-Wittenberg (DE)
ORCID: Reuter, G
Saumweber, H
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1993-12
Volume: 90
Issue: 23
Pages: 11376-11380
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.90.23.11376
PMC: PMC47985
OpenAlex: W2084940129
Cited by: 178
References: 20
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2021: 2 · 2020: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 6
FWCI: 4.38
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: position effect variegation, chromatin proteins, Tramtrack, Broad-Complex, transcription factors, polytene chromosomes, Drosophila
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Chromatin, Cloning, Molecular, DNA Transposable Elements, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Imprinting, Psychological, Molecular Sequence Data, RNA, Messenger, Transcription Factors, Genes, Insect

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The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

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