The DOI matches its Crossref record; 20 of the 20 references it cites were found in a registry or an index.
The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.
Open accessAbstract
In Drosophila modifying mutations of position-effect variegation have been successfully used to genetically dissect chromatin components. The enhancer of position-effect variegation E(var)3-93D [formerly E-var(3)3] encodes proteins containing a domain common to the transcriptional regulators tramtrack and the products of the Broad complex. It interacts with a number of chromatin genes that suppress position-effect variegation. Mutations in E(var)3-93D exhibit an imprinting-like effect on the Y chromosome. This effect is transmitted paternally over several generations. Homeotic transformations in E(var)3-93D mutants indicate an involvement of the gene products in regulation of homeotic gene complexes. An antiserum raised against E(var)3-93D protein detects this chromosomal protein in a large subset of sites in polytene chromosomes. Our genetic and molecular data suggest that the proteins of E(var)3-93D are generally involved in establishing and/or maintaining an open chromatin conformation.
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“Approximately one-third of these have been identified and, as expected, most turn out to play critical roles in epigenetic gene silencing [1,9].”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [9]
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The POZ domain: a conserved protein-protein interaction motif.Preprint
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“Because of its conservation among modifier genes of position effect variegation, the BTB domain has been suggested to mediate protein interactions responsible for establishing certain chromatin structures (15, 17).”
BackgroundTransgenerational Epigenetic Effects
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Position-Effect Variegation, Heterochromatin Formation, and Gene Silencing in Drosophila
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Self-citation
Metadata
- Authors
- Dorn, R., Krauss, V, Reuter, G., & Saumweber, H.
- Affiliations
- Martin Luther University Halle-Wittenberg (DE)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1993-12
- Volume
- 90
- Issue
- 23
- Pages
- 11376-11380
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC47985
- OpenAlex
- W2084940129
- Cited by
- 178
- References
- 20
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2021: 2 · 2020: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 6
- FWCI
- 4.38
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
- Keywords
- position effect variegation, chromatin proteins, Tramtrack, Broad-Complex, transcription factors, polytene chromosomes, Drosophila
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Chromatin, Cloning, Molecular, DNA Transposable Elements, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Imprinting, Psychological, Molecular Sequence Data, RNA, Messenger, Transcription Factors, Genes, Insect
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