Cited by 178Genomics and Chromatin DynamicsEpigenetics and DNA MethylationChromosomal and Genetic Variations

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The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

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Dorn, R, Krauss, V, Reuter, G, Saumweber, H·1993·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.90.23.11376PMC PMC47985

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Abstract

In Drosophila modifying mutations of position-effect variegation have been successfully used to genetically dissect chromatin components. The enhancer of position-effect variegation E(var)3-93D [formerly E-var(3)3] encodes proteins containing a domain common to the transcriptional regulators tramtrack and the products of the Broad complex. It interacts with a number of chromatin genes that suppress position-effect variegation. Mutations in E(var)3-93D exhibit an imprinting-like effect on the Y chromosome. This effect is transmitted paternally over several generations. Homeotic transformations in E(var)3-93D mutants indicate an involvement of the gene products in regulation of homeotic gene complexes. An antiserum raised against E(var)3-93D protein detects this chromosomal protein in a large subset of sites in polytene chromosomes. Our genetic and molecular data suggest that the proteins of E(var)3-93D are generally involved in establishing and/or maintaining an open chromatin conformation.

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RETRACTED ARTICLE: The BTB Domain of bric à brac Mediates Dimerization In Vitro
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Enhancer of Polycomb Is a Suppressor of Position-Effect Variegation in Drosophila melanogaster
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“Genetic evidence for the interaction has been demonstrated in various double combinations of mod(mdg4) and certain trx group mutations ( Dorn et al., 1993b; Gerasimova & Corces, 1998; Buchner et al., 2000).”
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Identification of the Drosophila interband-specific protein Z4 as a DNA-binding zinc-finger protein determining chromosomal structure
Eggert, H., Gorchakov, A. A., & Saumweber, H. (2004) · Journal of Cell Science · doi:10.1242/jcs.01292 · Cited by 70
“…by the finding that other Drosophila proteins involved in chromosomal domain organization like Suppressor of Hairy wing [Su(Hw)] (Spana et al., 1988; Harrison et al., 1993) and Mod(mdg4) also bind to numerous interbands (Dorn et al., 1993; Gerasimova and Corces, 1998; Büchner et al., 2000).”
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Positional signaling by hedgehog in Drosophila imaginal disc development
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The 190 kda centrosome-associated protein of Drosophila melanogaster contains four zinc finger motifs and binds to specific sites on polytene chromosomes
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“SUHW may interact with the transcription factor-like products of the E(var)3-93D gene, which positively regulate expression of homeotic genes (10).”
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In vivo assay for protein-protein interactions using Drosophila chromosomes
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“... are mirrored by molecular and genetic similarities: proteins controlling both forms of silencing have been found to share structural homologies [e.g., the chromo domain shared by HP1 and Pc protein (Paro and Hogness 1991); the SET domain shared by Su(var)3-9, E(z), and trx proteins (Tschiersch et al. 1994)], and c…”
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Role of the male specific lethal (msl) Genes in Modifying the Effects of Sex Chromosomal Dosage in Drosophila
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1 Paternal Effects in Drosophila: Implications for Mechanisms of Early Development
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Life and death decisions: the role of the IAPs in modulating programmed cell death
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“Previously characterized protein products of the mod gene are believed to play a role in the regulation of chromosome structure.(55) The DOOM protein possesses a unique carboxy terminus that interacts with the BIR domains of the baculovirus IAPs.”
Background
Chapter 1 Cellular Mechanism for Targeting Heterochromatin Formation in Drosophila
Eissenberg, J. C., & Reuter, G. (2009) · International review of cytology · doi:10.1016/s1937-6448(08)01801-7 · Cited by 62
Self-citation
Genomic Imprinting and Position-Effect Variegation in Drosophila melanogaster
Lloyd, V. K., Sinclair, D. A., & Grigliatti, T. A. (1999) · Genetics · doi:10.1093/genetics/151.4.1503 · Cited by 59
An actin-related protein in Drosophila colocalizes with heterochromatin protein 1 in pericentric heterochromatin
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The Y Chromosome of Drosophila melanogaster Exhibits Chromosome-Wide Imprinting
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Protecting against promiscuity: the regulatory role of insulators
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The Drosophila pipsqueak gene encodes a nuclear BTB-domain-containing protein required early in oogenesis
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Cross-talking histones: implications for the regulation of gene expression and DNA repair
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The Dose of a Putative Ubiquitin-Specific Protease Affects Position-Effect Variegation in Drosophila melanogaster
Henchoz, S., Rubertis, F. D., Pauli, D., & Spierer, P. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.10.5717 · Cited by 52
“The trithorax-like gene encodes the GAGA transcription factor (17), a key component for chromatin remodelling implicated in nucleosome displacement needed for full gene activation (56, 65); E(var)393D contains a tramtrack domain, common to several transcriptional activators (12); and E(var)3-93E encodes the E2F transc…”
Trans -splicing as a Novel Mechanism to Explain Interallelic Complementation in Drosophila
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Position-effect variegation in Drosophila depends on the dose of the gene encoding the E2F transcriptional activator and cell cycle regulator
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Complex patterns of inheritance of an imprinted murine transgene suggest incomplete germline erasure
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Diverse Mitotic and Interphase Functions of Condensins in Drosophila
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“Moreover, chromatin-bridging phenotypes similar to those of gluon mutants had been observed in Su(var)2055 embryos (Kellum and Alberts 1995), which are null mutants for the gene-encoding heterochromatin protein 1 (HP1) with dosage-dependent effects on PEV (Eissenberg et al. 1992; Dorn et al. 1993).”
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Distinct Roles of Chromatin Insulator Proteins in Control of the Drosophila Bithorax Complex
Savitsky, M., Kim, M. H., Кравчук, О. И., & Schwartz, Y. B. (2015) · Genetics · doi:10.1534/genetics.115.179309 · Cited by 42
“…proteins within their common N-terminal part are lethal and have pleiotropic phenotypes that range from meiotic chromosome segregation defects in males (Soltani-Bejnood et al. 2007) to enhancement of the position effect variegation (Dorn et al. 1993; Buchner et al. 2000; Gause et al. 2001).”
BackgroundInfluential
Two Arabidopsis homologs of the animal trithorax genes: a new structural domain is a signature feature of the trithorax gene family
Álvarez-Venegas, R., & AVRAMOVA, Z. V. (2001) · Gene · doi:10.1016/s0378-1119(01)00524-8 · Cited by 41

Authors: Dorn, R., Krauss, V, Reuter, G., & Saumweber, H.
Affiliations: Martin Luther University Halle-Wittenberg (DE)
ORCID: Reuter, G
Saumweber, H
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1993-12
Volume: 90
Issue: 23
Pages: 11376-11380
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.90.23.11376
PMC: PMC47985
OpenAlex: W2084940129
Cited by: 178
References: 20
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2021: 2 · 2020: 2 · 2017: 1 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 4 · 2012: 6
FWCI: 4.38
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Chromosomal and Genetic Variations
Keywords: position effect variegation, chromatin proteins, Tramtrack, Broad-Complex, transcription factors, polytene chromosomes, Drosophila
MeSH terms: Amino Acid Sequence, Animals, Base Sequence, Chromatin, Cloning, Molecular, DNA Transposable Elements, Drosophila melanogaster, Enhancer Elements, Genetic, Gene Expression Regulation, Imprinting, Psychological, Molecular Sequence Data, RNA, Messenger, Transcription Factors, Genes, Insect

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The enhancer of position-effect variegation of Drosophila, E(var)3-93D, codes for a chromatin protein containing a conserved domain common to several transcriptional regulators.

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