Cited by 309Genomics and Chromatin DynamicsNuclear Structure and FunctionChromosomal and Genetic Variations

Position effect variegation and chromatin proteins

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Reute, Gunter, Spierer, Pierre·1992·BioEssays

Abstract

Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure of heterochromatin can spread into euchromatic regions, which then assume the morphology of heterochromatin and become transcriptionally inactive. In position‐effect variegation (PEV) therefore, gene inactivation results from a change in chromatin structure. PEV has been intensively investigated in the fruitfly Drosophila, where the phenomenon allows a genetic dissection of chromatin components. Consequently, many genes have been identified which, when mutated, act as dominant modifiers (suppressors or enhancers) of PEV. Data available already demonstrate that genetic, molecular and developmental analysis of these genes provides an avenue to the identification of regulatory and structural chromatin components, and hence to fundamental aspects of chromosome structure and function.

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Crossref · 10.1002/bies.950140907

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Authors
Reute, G., & Spierer, P.
Affiliations
  • Martin Luther University Halle-Wittenberg (DE)
  • University of Geneva (CH)
Venue
BioEssays
Publisher
Wiley
Published
1992-09
Volume
14
Issue
9
Pages
605-612
ISSN
  • 0265-9247 (ISSN-L)
  • 1521-1878
OpenAlex
W2035169037
Cited by
309
References
54
Citations by year
2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 6
FWCI
1.92
Type
journal article
Language
en
Open access
Locations
  • BioEssays (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Funders
  • Deutsche Forschungsgemeinschaft
  • Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
Keywords
position effect variegation, chromatin proteins, heterochromatin, euchromatin, chromosomal rearrangements, gene inactivation, Drosophila, chromatin structure
MeSH terms
Animals, Chromosomal Proteins, Non-Histone, Drosophila melanogaster, Eye Color, Female, Gene Expression Regulation, Genes, Dominant, Heterochromatin, Chromosome Inversion, Male, Phenotype, Suppression, Genetic, X Chromosome, Y Chromosome, Genomic Imprinting

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