Position effect variegation and chromatin proteins
Open accessAbstract
Variegated phenotypes often result from chromosomal rearrangements that place euchromatic genes next to heterochromatin. In such rearrangements, the condensed structure of heterochromatin can spread into euchromatic regions, which then assume the morphology of heterochromatin and become transcriptionally inactive. In position‐effect variegation (PEV) therefore, gene inactivation results from a change in chromatin structure. PEV has been intensively investigated in the fruitfly Drosophila, where the phenomenon allows a genetic dissection of chromatin components. Consequently, many genes have been identified which, when mutated, act as dominant modifiers (suppressors or enhancers) of PEV. Data available already demonstrate that genetic, molecular and developmental analysis of these genes provides an avenue to the identification of regulatory and structural chromatin components, and hence to fundamental aspects of chromosome structure and function.
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Drosophila modifier screens suggest there are between 100 and 150 genes that modify position effect variegation.
“These screens have been continued to saturation and the results suggest that there are between 100 and 150 such genes [7,8].”
From A genome-wide screen for modifiers of transgene variegation identifies genes with critical roles in development (2008) · cites this paper as [7]
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- Authors
- Reute, G., & Spierer, P.
- Affiliations
- Martin Luther University Halle-Wittenberg (DE)
- University of Geneva (CH)
- Venue
- BioEssays
- Publisher
- Wiley
- Published
- 1992-09
- Volume
- 14
- Issue
- 9
- Pages
- 605-612
- ISSN
- 0265-9247 (ISSN-L)
- 1521-1878
- OpenAlex
- W2035169037
- Cited by
- 309
- References
- 54
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 3 · 2017: 6 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 6
- FWCI
- 1.92
- Type
- journal article
- Language
- en
- Open access
- Locations
- BioEssays (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Deutsche Forschungsgemeinschaft
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Keywords
- position effect variegation, chromatin proteins, heterochromatin, euchromatin, chromosomal rearrangements, gene inactivation, Drosophila, chromatin structure
- MeSH terms
- Animals, Chromosomal Proteins, Non-Histone, Drosophila melanogaster, Eye Color, Female, Gene Expression Regulation, Genes, Dominant, Heterochromatin, Chromosome Inversion, Male, Phenotype, Suppression, Genetic, X Chromosome, Y Chromosome, Genomic Imprinting
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